Patents by Inventor Don Straus
Don Straus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230120417Abstract: The invention provides devices that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient detection of individual microscopic targets at low magnification for highly sensitive testing. The invention does not require washing steps and thus allows sensitive and specific detection while simplifying manual operation and lowering costs and complexity in automated operation. In short, the invention provides devices that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests.Type: ApplicationFiled: December 16, 2022Publication date: April 20, 2023Inventors: Greg Yantz, Don Straus, Gordon Siek, Damon Dehart
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Publication number: 20230077406Abstract: The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance.Type: ApplicationFiled: October 12, 2022Publication date: March 16, 2023Inventor: Don STRAUS
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Patent number: 11583853Abstract: The invention provides devices that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient detection of individual microscopic targets at low magnification for highly sensitive testing. The invention does not require washing steps and thus allows sensitive and specific detection while simplifying manual operation and lowering costs and complexity in automated operation. In short, the invention provides devices that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests.Type: GrantFiled: August 16, 2019Date of Patent: February 21, 2023Assignee: FIRST LIGHT DIAGNOSTICS, INC.Inventors: Greg Yantz, Don Straus, Gordon Siek, Damon Dehart
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Patent number: 11499176Abstract: The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance.Type: GrantFiled: March 1, 2016Date of Patent: November 15, 2022Assignee: RAPID MICRO BIOSYSTEMS, INC.Inventor: Don Straus
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Publication number: 20220033889Abstract: The invention provides a version of fluorescent in situ hybridization (FISH) in which all the steps are performed at physiological temperatures, i.e., body temperature, to detect and identify pathogenic bacteria in clinical samples. Methods of the invention use species-specific fluorescent probes to label clinically important infectious bacteria. A sample such as a urine sample is loaded into a cartridge, fluorescently labeled, and imaged with a microscope. Labelled bacteria are pulled down onto an imaging surface and a dye cushion is used to keep unbound probes off of the imaging surface. A microscopic image of the surface shows whether and in what quantities the infectious bacteria are present in the clinical sample.Type: ApplicationFiled: October 4, 2019Publication date: February 3, 2022Inventor: Don Straus
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Publication number: 20210349082Abstract: The invention provides multi-function instruments for automatically and simultaneously carrying out a variety of tests including identification of targets in specimens and antimicrobial susceptibility testing thereof. Application-specific cartridges are pre-loaded with all required reagents and allow for tests to be performed in a single testing device with no specimen preparation to, for example, rapidly detect infections, identify infectious pathogens, and analyze their susceptibility to various antimicrobial agents. Instruments include various stations for carrying out test steps that can be randomly accessed in any order dictated by the computer-controlled instrument. A carousel stores and incubates cartridges and, with a mechanical conveyor arm, transfers the cartridges between the required stations to carry out the tests. A plurality of different tests may be performed on a plurality of targets within an instrument, and the plurality of targets may be disposed in a single cartridge.Type: ApplicationFiled: October 4, 2019Publication date: November 11, 2021Inventor: Don Straus
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Publication number: 20190366338Abstract: The invention provides devices that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient detection of individual microscopic targets at low magnification for highly sensitive testing. The invention does not require washing steps and thus allows sensitive and specific detection while simplifying manual operation and lowering costs and complexity in automated operation. In short, the invention provides devices that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests.Type: ApplicationFiled: August 16, 2019Publication date: December 5, 2019Inventors: Greg Yantz, Don Straus, Gordon Siek, Damon Dehart
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Publication number: 20190324034Abstract: Methods and cartridges for detecting targets are provided. A biological sample is introduced to a cartridge. Targets in the sample are photonically labeled with fluorescent particles in a first liquid layer in the cassette. Photonically-labeled targets are separated out of the sample into a second liquid layer within the cassette, detected, and counted to show presence of the targets in the subject. Cartridges include a receiving reservoir, a mixing well for introducing the sample to photonic labels and magnetic particles, and an imaging well for detecting and counting targets from the sample. The sample may be a human stool sample. A filter may be used to filter particulates out of the sample.Type: ApplicationFiled: April 19, 2019Publication date: October 24, 2019Inventors: Jayson L. Bowers, Michael Cappillino, Sadanand Gite, Don Straus
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Patent number: 10384203Abstract: The invention provides devices that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient detection of individual microscopic targets at low magnification for highly sensitive testing. The invention does not require washing steps and thus allows sensitive and specific detection while simplifying manual operation and lowering costs and complexity in automated operation. In short, the invention provides devices that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests.Type: GrantFiled: September 24, 2009Date of Patent: August 20, 2019Assignee: First Light Biosciences, Inc.Inventors: Greg Yantz, Don Straus, Gordon Siek, Damon DeHart
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Patent number: 10000788Abstract: The invention features methods for rapidly and sensitively identifying molecular targets in medical, industrial, and environmental samples. The invention labels target molecules and then images them using large area imaging. Diagnostic tests based on the invention can be rapid, ultrasensitive, quantitative, multiplexed, and automated. A broad range of infectious agents (e.g., bacteria, viruses, fungi, and parasites) and molecules (e.g., proteins, DNA, RNA, hormones, and drugs) can be detected by the methods. The invention enables rapid, ultra-sensitive, cost-effective, and portable assays. The ability of the invention to detect low levels of target molecules rapidly and cost-effectively results from the combination of high intensity labeling, formats that facilitate rapid reaction kinetics, and large area imaging based using either instrumentation made from off-the-shelf commercial components or no instrumentation at all.Type: GrantFiled: September 6, 2002Date of Patent: June 19, 2018Assignee: First Light Biosciences, Inc.Inventor: Don Straus
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Patent number: 9643180Abstract: The invention provides an improved method for sensitive and specific detection of target molecules, cells, or viruses. The inventive method uses large area imaging to detect individual labeled targets complexed with a target-specific selection moiety. The invention eliminates wash steps through the use of target-specific selection through one or more liquid layers that can contain optical dye and density agents. By eliminating washes the invention simplifies instrumentation engineering and minimizes user steps and costs. The invention uses sensitive image analysis to enumerate individual targets in a large area, is scalable, and can be deployed in systems ranging in complexity from manual to highly automated.Type: GrantFiled: September 24, 2009Date of Patent: May 9, 2017Assignee: First Light Biosciences, Inc.Inventors: Ezra Abrams, Sadanand Gite, Lisa Shinefeld, Don Straus, Gordon Siek, Greg Yantz
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Publication number: 20170029864Abstract: The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance.Type: ApplicationFiled: March 1, 2016Publication date: February 2, 2017Inventor: Don STRAUS
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Patent number: 9290382Abstract: The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance.Type: GrantFiled: September 1, 2009Date of Patent: March 22, 2016Assignee: Rapid Micro BiosystemsInventor: Don Straus
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Patent number: 9090462Abstract: The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance.Type: GrantFiled: March 19, 2010Date of Patent: July 28, 2015Assignee: Rapid Micro Biosystems, Inc.Inventor: Don Straus
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Patent number: 9057046Abstract: The invention features devices for capturing and culturing cells (e.g., microorganisms, cells containing microorganisms, or cells from eukaryotic cell cultures) and methods of using these devices. One device is a cassette containing growth media that may be employed in an automated rapid enumeration system. The cassette has, for example, been enhanced with features for controlling surface flatness, optical imaging, controlled dehydration of semi solid nutrient media, controlled air and particle exchange, and automated handling. Another device of the invention is a filtration funnel that may used to concentrate cells in a sample onto a membrane.Type: GrantFiled: September 26, 2006Date of Patent: June 16, 2015Assignee: Rapid Micro Biosystems, Inc.Inventors: Douglas Browne, Don Straus, Chad Mace
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Publication number: 20120149007Abstract: The invention provides an improved method for sensitive and specific detection of target molecules, cells, or viruses. The inventive method uses large area imaging to detect individual labeled targets complexed with a target-specific selection moiety. The invention eliminates wash steps through the use of target-specific selection through one or more liquid layers that can contain optical dye and density agents. By eliminating washes the invention simplifies instrumentation engineering and minimizes user steps and costs. The invention uses sensitive image analysis to enumerate individual targets in a large area, is scalable, and can be deployed in systems ranging in complexity from manual to highly automated.Type: ApplicationFiled: September 24, 2009Publication date: June 14, 2012Applicant: Straus Holdings Inc.Inventors: Ezra Abrams, Sadanand Gite, Lisa Shinefeld, Don Straus, Gordon Siek, Greg Yantz
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Publication number: 20120046203Abstract: The invention provides analyzers that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient and specific selection and sensitive imaging detection of individual microscopic targets at low magnification. Automated embodiments allow efficient walk-away, on-demand, random-access high-throughput testing. The analyzers perform tests without requiring wash steps thus streamlining engineering and lowering costs. Thus, the invention provides analyzers that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests for analytes.Type: ApplicationFiled: September 24, 2009Publication date: February 23, 2012Applicant: Straus Holdings Inc.Inventors: Bruce Walsh, Boris Blanter, Matthew Barra, Brian Connolly, Greg Yantz, Paul Gervasio, Don Straus
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Publication number: 20120045826Abstract: The invention provides devices that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient detection of individual microscopic targets at low magnification for highly sensitive testing. The invention does not require washing steps and thus allows sensitive and specific detection while simplifying manual operation and lowering costs and complexity in automated operation. In short, the invention provides devices that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests.Type: ApplicationFiled: September 24, 2009Publication date: February 23, 2012Inventors: Greg Yantz, Don Straus, Gordon Siek, Damon DeHart
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Patent number: 8021848Abstract: The invention provides efficient methods for rapidly and sensitively identifying cellular and viral targets in medical, industrial, and environmental samples. The invention labels targets and then detects them using large area imaging. Diagnostic tests based on the invention can be rapid, ultrasensitive, quantitative, multiplexed, and automated. The tests minimize sample preparation and do not require nucleic acid amplification or cell culture. A broad range of cells and viruses can be detected by the tests. Tests based on the invention can deliver the high level sensitivity of nucleic acid amplification tests, the user-friendliness, and speed of immunoassays, as well as the cost effectiveness and quantification offered by microbiological tests. The invention embodies the best attributes of the current diagnostic technologies, while addressing gaps in the diagnostic repertoire.Type: GrantFiled: September 6, 2002Date of Patent: September 20, 2011Assignee: Straus Holdings Inc.Inventor: Don Straus
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Publication number: 20100248281Abstract: The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance.Type: ApplicationFiled: March 19, 2010Publication date: September 30, 2010Applicant: Rapid Micro Biosystems, Inc.Inventor: Don Straus