Abstract: A wearable sensor for measuring a parameter of human skin is described and includes a flexible body comprising sensor components formed on, adjacent or within the flexible body and configured to generate a first signal indicative of the parameter of human skin; microfabricated processing circuitry formed within the flexible body, coupled to the sensor components and configured to process the first signal to produce a second signal; and an antenna, formed on, adjacent or within the flexible body, the antenna being coupled to the processing circuitry and configured to transmit the second signal to an external device.

Abstract: A system and method for performing a biopsy of a target volume and a computing device for planning the same are provided. A three-dimensional ultrasound transducer captures ultrasound volume data from the target volume. A three-dimensional registration module registers the ultrasound volume data with supplementary volume data related to the target volume. A biopsy planning module processes the ultrasound volume data and the supplementary volume data in combination in order to develop a biopsy plan for the target volume. A biopsy needle biopsies the target volume in accordance with the biopsy plan.

Abstract: Biopsy of the prostate using 2D transrectal ultrasound (TRUS) guidance is the current gold standard for diagnosis of prostate cancer; however, the current procedure is limited by using 2D biopsy tools to target 3D biopsy locations. We have discovered a technique for patient-specific 3D prostate model reconstruction from a sparse collection of non-parallel 2D TRUS biopsy images. Our method can be easily integrated with current TRUS biopsy equipment and could be incorporated into current clinical biopsy procedures for needle guidance without the need for expensive hardware additions. We have demonstrated the model reconstruction technique using simulated biopsy images from 3D TRUS prostate images of 10 biopsy patients. This technique of model reconstruction is not limited to the prostate, but can be applied to the reconstruction of any tissue acquired with non-parallel 2-dimensional ultrasound images.

Abstract: An apparatus for determining a distribution of a selected therapy in a target volume is provided. A three-dimensional ultrasound transducer captures volume data from the target volume. A computing device is in communication with the three-dimensional ultrasound transducer for receiving the volume data and determining the distribution of the selected therapy in the target volume along a set of planned needle trajectories using the volume data. At least one of the needle trajectories is oblique to at least one other of the planned needle trajectories.

Abstract: Biopsy of the prostate using 2D transrectal ultrasound (TRUS) guidance is the current gold standard for diagnosis of prostate cancer; however, the current procedure is limited by using 2D biopsy tools to target 3D biopsy locations. We have discovered a technique for patient-specific 3D prostate model reconstruction from a sparse collection of non-parallel 2D TRUS biopsy images. Our method can be easily integrated with current TRUS biopsy equipment and could be incorporated into current clinical biopsy procedures for needle guidance without the need for expensive hardware additions. We have demonstrated the model reconstruction technique using simulated biopsy images from 3D TRUS prostate images of 10 biopsy patients. This technique of model reconstruction is not limited to the prostate, but can be applied to the reconstruction of any tissue acquired with non-parallel 2-dimensional ultrasound images.

Abstract: An apparatus for determining a distribution of a selected therapy in a target volume is provided. A three-dimensional ultrasound transducer captures volume data from the target volume. A computing device is in communication with the three-dimensional ultrasound transducer for receiving the volume data and determining the distribution of the selected therapy in the target volume along a set of planned needle trajectories using the volume data. At least one of the needle trajectories is oblique to at least one other of the planned needle trajectories.

Abstract: A system and method for performing a biopsy of a target volume and a computing device for planning the same are provided. A three-dimensional ultrasound transducer captures ultrasound volume data from the target volume. A three-dimensional registration module registers the ultrasound volume data with supplementary volume data related to the target volume. A biopsy planning module processes the ultrasound volume data and the supplementary volume data in combination in order to develop a biopsy plan for the target volume. A biopsy needle biopsies the target volume in accordance with the biopsy plan.

Abstract: A method of registering the position of an object moving in a target volume in an ultrasound imaging system includes capturing a first ultrasound image of a target volume. A second ultrasound image of the target volume is then captured after the capturing of the first ultrasound image. The position of the object in the target volume is identified using differences detected between the first and second ultrasound images. In another aspect, a region of interest in the target volume is determined. A segment of an operational scan range of a transducer of the ultrasound imaging system encompassing the region of interest is determined. The transducer is focused on the segment of the operational scan range during image capture.

Abstract: A method and system, employed in combination with a three-dimensional ultrasonographic imaging system, for assisting and placing at least one medical instrument into a prostate during a percutaneous prostrate therapeutic procedure. A process means for determining the spatial relationship between three-dimensional ultrasonographic images of the prostate generated via the transrectal transducer and a reference means. In addition, the method and system assists in guiding and placement of the medical instrument into a target location in the prostate.

Abstract: A method and apparatus is disclosed, employed in combination with an ultrasonographic system, for assisting in guiding and placing at least one medical instrument into a target tissue during a minimally invasive medical procedure. The apparatus comprises: a reference means; a processing means in communication with the ultrasonographic system; and a mounting means for mounting the reference means in a predetermined relationship to an ultrasonographic transducer. The reference means includes a plurality of apertures arranged in an predefined manner which are sized to permit at least one medical instrument to pass therethrough. The processing means determines the spatial relationship between the target tissue and the reference means and further merges a representation of the plurality of apertures with the ultrasonographic image to form a positioning image.

Abstract: A 3-D ultrasound imaging system for the eye, prostate and other organs, comprising an assembly onto which an ultrasound probe may be mounted, a motor and drive for either rotating or scanning the probe relative to the human organ under investigation, and a computer for executing proprietary software for controlling movement of the assembly to rotate or scan the probe. Ultrasound signals from the probe are processed via a clinical ultrasound machine for generating multiple images of the organ. The proprietary software being executed on the computer collects the 2-D ultrasound images of the clinical ultrasound machine and reconstructs these images to form a 3-D display which can be viewed and manipulated in real time, or stored for later retrieval.

Abstract: A three-dimensional ultrasound imaging system includes an ultrasound probe to direct ultrasound waves to and to receive reflected ultrasound waves from a target volume of a subject under examination. The ultrasound probe is swept over the target volume and the reflected ultrasound waves are conveyed to a computer wherein successive two-dimensional images of the target volume are reconstructed to form a three-dimensional image of the target volume. The three-dimensional image is displayed on the monitor of the computer. A user interface allows a user to manipulate the displayed image. Specifically, the entire displayed image may be rotated about an arbitrary axis, a surface of the displayed image may be translated to provide different cross-sectional views of the image and a selected surface of the displayed image may be rotated about an arbitrary axis. All of these manipulations can be achieved via a single graphical input device such as a mouse connected to the computer.