Abstract: System-directed checkpointing is accomplished following each checkpoint by mapping all memory pages, including read-only pages and read/write pages as read-only pages. Therefore, when an attempt is made to write to a page, a page-fault interrupt is generated. If the page is a read-only page, then normal page-fault interrupt protocol is followed. If the page is a read/write page that has temporarily been labeled read-only, the page is copied to a buffer and the memory map is changed to indicate that the page is now a read/write page. The pages in the buffer can then be used to restore the system after a fault. In accordance with another embodiment of the invention, after the aforementioned system interrupt occurs, the identity of the page is recorded in a backup computer, but the page itself is not copied. In addition, the locations of all pages modified through I/O events are also recorded.

Abstract: The present invention is directed toward radiolabeled farnesyl-protein transferase inhibitor compounds which are useful to label FPTase in assays, whether cell-based, tissue-based or in whole animal. The tracers can also be used in competitive binding assays to obtain information on the interaction of unlabeled FTIs with FPTase.

Abstract: The present invention is directed to radiolabeled neurokinin-1 receptor antagonists which are useful for the labeling and diagnostic imaging of neurokinin-1 receptors in mammals.

Abstract: A method of detecting counterfeit currency by contacting the currency to be tested with near infrared beams in the spectrum below 1250 namometers, measuring reflectance of the near infrared beams and comparing the reflectance values with those from genuine currency.

Abstract: Novel radiolabeled cholecystokinin-A (CCK-A) antagonists have been developed which, after intravenous injection, localize in the pancreas as a result of specific binding to CCK-A receptors. These tracers, when labeled with appropriate radiohalogens, are useful as commercial diagnostic imaging radiopharmaceuticals and radiotherapeutic drugs.

Abstract: Automatic dilution apparatus and method are provided, and are operable in conjunction with automated sample liquid analysis systems to automatically dilute sample liquids as supplied thereby to automated sample liquid analysis apparatus. One embodiment of the dilution apparatus operates to dilute the sample liquids by flowing the sample liquids from the analysis system sample liquid supply conduit, diluting the same, and returning the diluted sample liquids to the supply conduit for flow therethrough to the sample analysis apparatus for sample liquid analysis. Flow of undiluted sample liquids through the supply conduit is prevented attendant operation of the dilution apparatus. A second embodiment of the dilution apparatus operates to remove predetermined volumes of the sample liquids from the supply conduit, and to replace the same with like volumes of a diluent liquid; thereby diluting the sample liquids in the supply conduit for continued flow to the sample liquid analysis apparatus.

Abstract: A transport system is provided in which a plurality of samples are introduced into a carrier stream flowing through a conduit, whose inner surface is coated with an immiscible liquid film. The carrier stream can be a sequence of alternating gas and liquid segments which are in direct contact with each other and, thus, not encompassed by the immiscible liquid. Samples are introduced at various points along the conduit and, thus, the system allows for the collection and transport of samples from a plurality of remote locations to at least one central receiving station where they can, for example, be analyzed. Carryover between successive samples to be transported is effectively eliminated.

Abstract: Apparatus and method for obtaining a concentration gradient in a liquid sample analyzer including flowing a first liquid in a stream to fill a conduit, and continuing the flow of the first liquid along the conduit subsequent to the filling step. Combined with these steps is the step of changing the concentration of the first liquid by removing from the stream a predetermined varying volume of the first liquid and adding to the stream a predetermined proportional varying volume of a second liquid. There is also provided a method of serial dilutions of a liquid stream in a conduit by removal of a portion of the stream prior to each diluent addition for the purpose of conserving diluents which may be reagents.

Abstract: Apparatus and method for analyzing liquid sample comprising flowing a stream including a liquid continuously in a conduit, detecting a flow rate characteristic in the conduit and generating a signal in response thereto, and increasing, decreasing or maintaining, unchanged the flow rate of the stream in the conduit in response to the signal, the flow being increased or decreased by the flow into the conduit of another fluid without changing the concentration of the aforementioned liquid. The continuing flow of the liquid may be the flow of a segmented sample-reagent liquid, and the other fluid which is added may be a gas.