Patents by Inventor Donald A. G. Mickle

Donald A. G. Mickle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transplants for myocardial scars
    Publication number: 20080159997
    Abstract: A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart.
    Type: Application
    Filed: August 10, 2007
    Publication date: July 3, 2008
    Applicant: Genzyme Corporation
    Inventors: Donald A. G. Mickle, Ren-Ke Li, Richard D. Weisel
  • Transplants for myocardial scars
    Patent number: 7067121
    Abstract: A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart.
    Type: Grant
    Filed: August 23, 2004
    Date of Patent: June 27, 2006
    Assignee: Genzyme Corporation
    Inventors: Donald A. G. Mickle, Ren-Ke Li, Richard D. Weisel
  • Transplants for myocardial scars
    Publication number: 20040071669
    Abstract: A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart.
    Type: Application
    Filed: November 17, 2003
    Publication date: April 15, 2004
    Applicant: Genzyme Corporation
    Inventors: Donald A.G. Mickle, Ren-Ke Li, Richard D. Weisel
  • Transplants for myocardial scars
    Patent number: 6682730
    Abstract: A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: January 27, 2004
    Assignee: Genzyme Corporation
    Inventors: Donald A. G. Mickle, Ren-Ke Li, Richard D. Weisel
  • Transplants for myocardial scars
    Patent number: 6579523
    Abstract: A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: June 17, 2003
    Assignee: Genzyme Corporation
    Inventors: Donald A. G. Mickle, Ren-Ke Li, Richard D. Weisel
  • Transplants for myocardial scars
    Publication number: 20020127210
    Abstract: A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart.
    Type: Application
    Filed: January 29, 2002
    Publication date: September 12, 2002
    Inventors: Donald A. G. Mickle, Ren-Ke Li, Richard D. Weisel
  • Transplants for myocardial scars and methods and cellular preparations
    Patent number: 6110459
    Abstract: A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart. Also provided is a method of isolating and culturing cardiomyocytes for use in such grafts.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: August 29, 2000
    Inventors: Donald A. G. Mickle, Ren-Ke Li, Richard D. Weisel
  • Transplants for myocardial scars
    Patent number: 6099832
    Abstract: A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: August 8, 2000
    Assignee: Genzyme Corporation
    Inventors: Donald A. G. Mickle, Ren-Ke Li, Richard D. Weisel
  • Chroman-2-carboxamide conjugates and their use for treatment of reperfusion injury
    Patent number: 5099012
    Abstract: Conjugates of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid with p-aminophenylsaccharides, with aminoalkyl-derivatized dextrans and with polylysines and polyornithines are prepared by condensation using diimides. Methods and compositions for the use of such conjugates to protect mammals from reperfusion injury are also disclosed.
    Type: Grant
    Filed: December 11, 1990
    Date of Patent: March 24, 1992
    Assignee: Eastman Kodak Company
    Inventors: Tai-Wing Wu, Donald A. G. Mickle
  • Pharmaceutical compositions for the prevention and treatment of oxidant injuries
    Patent number: 5080886
    Abstract: The combination of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid with a superoxide dismutase optionally containing a catalase and ascorbic acid provides enhanced protection from oxidant injury.Administration of 6-hydroxy-2,5,7,8-tetramethyl chroman-2-carboxylic acid, SOD, and optionally CAT and/or ascorbic acid prior to or simultaneously with resuming normal blood supply to mammalian tissue following ischemia provides substantial protection from tissue damage that otherwise is observed upon reperfusion. Administration of Vitamin E, SOD, and CAT similarly provide protection from oxidant injury.
    Type: Grant
    Filed: January 5, 1990
    Date of Patent: January 14, 1992
    Assignee: Sterling Drug Inc.
    Inventors: Donald A. G. Mickle, Tai-Wing Wu
  • Protection of heart tissue from reperfusion injury
    Patent number: 4877810
    Abstract: Administration of chroman, 6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, prior to or simultaneously with resuming normal blood supply to the heart following ischemia provides substantial protection from tissue damage that otherwise is observed upon reperfusion of the heart.
    Type: Grant
    Filed: February 5, 1988
    Date of Patent: October 31, 1989
    Assignee: Eastman Kodak Company
    Inventors: Donald A. G. Mickle, Tai-Wing Wu