Abstract: A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, athiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels.

Abstract: Substrates having formulations disposed thereon, wherein the formulations have improved transfer rates from the substrate to skin, are disclosed herein. More particularly, the formulations can be applied to nonwoven, particularly elastomeric substrates, as well as tissue paper, and can be easily and efficiently transferred from the substrate to the skin of a user upon intimate contact thereto. Laminated articles using one or more of the substrates having the formulations disposed thereon are further disclosed.

Abstract: The system and method disclosed herein provides an integrated and automated workflow, sensor, and reasoning system that automatically detects breaches in protocols, appropriately alarms and records these breaches, facilitates staff adoption of protocol adherence, and ultimately enables the study of protocols for care comparative effectiveness. The system provides real-time alerts to medical personnel in the actual processes of care, thereby reducing the number of negative patient events and ultimately improving staff behavior with respect to protocol adherence.

Abstract: A method for the processing of potassium containing materials comprises: (i) Separation of a potassium containing mineral from gangue minerals; (ii) Acid leaching whereby substantially all potassium, iron, aluminum and magnesium is solubilized and mixed potassium/iron double salt formed; (iii) Selectively crystallizing the mixed potassium/iron double salt formed in the leach step (ii); (iv) Second separation to separate the mixed potassium/iron double salt formed in step (iii); (v) Thermal decomposition to produce an iron oxide, a potassium salt and one or more phosphates; (vi) Leaching the product of the thermal decomposition; (vii) Third separation to separate the iron oxide and phosphate from the potassium salt; (viii) Recovering the potassium salt by crystallization; (ix) Separating the iron oxide and phosphate of step (vii) by leaching and subsequent solid liquid separation; and (x) Precipitating phosphate from liquor produced in step (ix) through the addition of a base.

Abstract: A method and system for providing access to and control of parameters within a scenegraph includes redefining components or nodes' semantic within a scenegraph. The set of components or nodes (depending on the scenegraph structure) are required to enable access from the Application User Interface to selected scenegraph information. In one embodiment, a user interface is generated for controlling the scenegraph parameters. In addition, constraints can be implemented that allow or disallow access to certain scenegraph parameters and restrict their range of values.

Abstract: Some embodiments are directed to an Internet of Things (“IoT”) associate to facilitate implementation of a digital twin of a twinned physical system. The IoT associate may include a communication port to communicate with at least one component, the at least one component comprising a sensor or an actuator associated with the twinned physical system, and a gateway to exchange information via the IoT. A computer processor and local data storage, coupled to the communication port and gateway, may receive a digital twin model from a data warehouse via the IoT. The computer processor may be programmed to, for at least a selected portion of the twinned physical system, execute the digital twin model in connection with the at least one component and operation of the twinned physical system.

Abstract: A fastening device may include a hollow void. The hollow void may contain an inner coil proximate to a first end of the device, a sensing portion to sense a characteristic associated with the fastening device during a sensing time window, and a controller. The controller may rectify an alternating current from the inner coil during a charging time window, store energy associated with the rectified alternating current, and use the stored energy to charge the sensing portion during the sensing time window. An outer coil outside the fastening device may be located proximate to a second end of the device as compared to the inner coil. An interface portion outside the fastening device may provide an alternating current to the outer coil during the charging time window, detect the sensed characteristic via the outer coil during the sensing time window, and transmit an indication of the detected characteristic value.

Abstract: An installed product includes mechanical components and associated sensors. A computer is programmed with an operational optimization model for the installed product, including modeling of the mechanical components and sensors. The computer is also programmed with a probability estimation model that provides an estimate of a difference measure related to input and output of the installed product. Sensor data is received, which had been generated during operation of the installed product. Output is generated from the operational optimization model based on the received sensor data. Output is generated from the probability estimation model based at least in part on the output from the operational optimization model. At least one installed product component is modified based at least in part on the output from the probability estimation model.

Abstract: Disclosed are corrosion inhibitor compounds and compositions useful for preventing or inhibiting corrosion of surfaces found in cooling water applications. In some embodiments, the surfaces may include mild steel, aluminum, brass, copper, galvanized steel, a copper alloy, admirality brass, or any combination thereof. Also disclosed are methods of using the compounds and compositions as corrosion inhibitors. In some embodiments, the corrosion inhibitor compounds and compositions are used in cooling water applications.

Abstract: The present disclosure relates to the reduction of pressure ulcers and falls with respect to patients with physical or cognitive impairments who are in bed. A control system assures that the bed and ancillary apparatus are physically set and that patient behaviors are responded to by care providers. Motion is monitored with a non-mutually exclusive portfolio of sensors, and this information is used by one or more reasoning engines. An integrated clinical workflow is informed by the patterns of movement and then the physical environment, patient interaction, and care provider workflow are controlled to reduce the incidence of falls and pressure ulcers in bed ridden patients.

Abstract: The system and method disclosed herein provides an integrated and automated workflow, sensor, and reasoning system that automatically detects breaches in protocols, appropriately alarms and records these breaches, facilitates staff adoption of protocol adherence, and ultimately enables the study of protocols for care comparative effectiveness. The system provides real-time alerts to medical personnel in the actual processes of care, thereby reducing the number of negative patient events and ultimately improving staff behavior with respect to protocol adherence.

Abstract: A method of providing a recommendation for optimizing operations of a set of industrial assets is disclosed. Digital twins of the set of industrial assets are generated. The digital twins include data structures representing states of each of a plurality of subsystems of the set of industrial assets over a time period. The states are estimated based on an application of simulations using cumulative damage models. The cumulative damage models model the effects of exogenous factors on the operation of the set of industrial assets over the time period. The digital twins are analyzed with respect to simulated operating performances to determine an optimized control of operations of the industrial assets. The optimized control of operations is calculated to jointly and severally to increase the specified operating performance criteria in time present and future of the industrial assets or decrease an economic risk associated with the operation of the industrial assets, within a specified probability.

Abstract: A method of providing a first set of computer systems with access to a recommendation pertaining to operation of one or more assets based on the one or more assets being in revenue service or in repair is disclosed. Operations data and inspection data is collected at the first set of computer systems. The operations data and inspection data pertains to operating asset states of one or more fleets of aircraft over a time period. The operations data and the inspection data is stored in one or more databases of a second set of computer systems. Assumptions of control input values are derived for use by the first set of computer systems based on the operations data and the inspection data. A financial objective and constraints analysis is performed with a simulation system for one or more assets of the one or more fleets of aircraft. The cost savings analysis includes identifying a modification of at least one of a set of the control input values.

Abstract: A method of generating a recommendation of terms of an aircraft services contract is disclosed. Operations data pertaining to a planned usage of each aircraft of a fleet of aircraft is received. The operations data pertains to the fleet of aircraft for which an aircraft services customer seeks to enter into a services contract with an aircraft services provider. The operations data includes flight schedule data and flight policy data specific to each of the aircraft. Historical data pertaining to actual usage of other fleets of aircraft with respect to the flight schedule data and the flight policy data is analyzed. The analyzing includes generating an estimation of a risk associated with the services contract from the perspective of the aircraft services provider. An acceptable price for the services contract is generated such that the risk is mitigated from the perspective of the services provider. The terms pertaining to the service contract are communicated for presentation in a user interface.

Abstract: A method of providing a first set of computer systems with access to a recommendation pertaining to operation of one aircraft in one or more fleets of aircraft is disclosed. Operations data is collected at the first set of computer systems. The operations data pertains to operations of the one or more fleets of aircraft over a time period. The operations data is stored in one or more databases of a second set of computer systems. The operations data includes values corresponding to fields in the one or more databases. The fields represent at least one of policy data pertaining to one or more operations policies, flight schedule data pertaining to one or more flight schedules, and operating cost data pertaining to operating costs associated with the one or more fleets of aircraft. Assumptions of control input values are derived for use by the first set of computer systems based on the operations data.

Abstract: A method of presenting a recommendation in a user interface for use in optimization operation of industrial assets. Digital twins are generated for a set of industrial assets. The digital twins include data structures representing estimated states of each of a plurality of subsystems of the set of industrial assets over a time period based on an application of simulations using cumulative damage models. The cumulative damage models modeling the effects of exogenous factors on the operation of the set of industrial assets over the time period. Based on an uncertainty level of at least one of the estimated states transgressing an uncertainty threshold, directed actual state data is requested from an inspection system deployed in a field of at least one of the industrial assets. Based on a receiving of the actual state data, the data structures are updated to include the actual state data. The uncertainty level of the estimated states of each of the plurality of subsystems is also updated.

Abstract: A method for the processing of potassium containing materials comprises: (i) Separation of a potassium containing mineral from gangue minerals; (ii) Acid leaching whereby substantially all potassium, iron, aluminium and magnesium is solubilised and mixed potassium/iron double salt formed; (iii) Selectively crystallising the mixed potassium/iron double salt formed in the leach step (ii); (iv) Second separation to separate the mixed potassium/iron double salt formed in step (iii); (v) Thermal decomposition to produce an iron oxide, a potassium salt and one or more phosphates; (vi) Leaching the product of the thermal decomposition; (vii) Third separation to separate the iron oxide and phosphate from the potassium salt; (viii) Recovering the potassium salt by crystallisation; (ix) Separating the iron oxide and phosphate of step (vii) by leaching and subsequent solid liquid separation; and (x) Precipitating phosphate from liquor produced in step (ix) through the addition of a base.

Abstract: Systems and methods for multi-resource scheduling are disclosed and described. An example apparatus includes a scheduler engine configured to enable clinical system(s) to operate with the scheduler engine in an analytical mode and an operating mode. When in the analytical mode, the scheduler engine is to dynamically calculate one or more binding constraints on the one or more clinical systems for scheduling. When in the operating mode, the scheduler engine is to manage and output a schedule for the one or more clinical systems based on the one or more binding constraints calculated in the analytical mode. The example scheduler engine is to dynamically switch between the analytical mode and the operating mode based at least in part on a probabilistic determination of delay associated with the schedule.

Abstract: The system and method disclosed herein provides an integrated and automated workflow, sensor, and reasoning system that automatically detects breaches in protocols, appropriately alarms and records these breaches, facilitates staff adoption of protocol adherence, and ultimately enables the study of protocols for care comparative effectiveness. The system provides real-time alerts to medical personnel in the actual processes of care, thereby reducing the number of negative patient events and ultimately improving staff behavior with respect to protocol adherence.

Abstract: An apparatus may implement a digital twin of a twinned physical system such that one or more sensors to sense values of one or more designated parameters of the twinned physical system. A computer processor may receive data associated with the sensors and, for at least a selected portion of the twinned physical system, monitor a condition of the selected portion of the twinned physical system and/or assess a remaining useful life of the selected portion based at least in part on the sensed values of the one or more designated parameters. A communication port may transmit information associated with a result generated by the computer processor. The one or more sensors may sense values of the one or more designated parameters, and the computer processor may perform the monitoring and/or assessing, when the twinned physical system is not operating.