Abstract: The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

Abstract: The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

Abstract: The present invention provides a system and method for providing a sales professional with the ability to create and tailor web-sites comprising rich media content for a potential customer. In this manner a potential customer is presented with a personalised sales message thereby possibly increasing the potential for a sale. The present invention provides an end-to-end integrated system enabling this procedure. Initially, the system enables the obtaining of information relating to potential customers (end users) who may be directed to a personalised sales web-site. Using this collected information and previously collected customer information from other sources or previous interactions, the system creates and directs a potential customer to a personalized web-site for the particular sales campaign.

Abstract: The present invention relates to new compounds of formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.

Abstract: The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, X4, R, R1, R2, R3, R4, R5, R6, R7, m, n, o, p and q are defined as in any one of claims 1 to 12, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.

Abstract: The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, R1, R2, m and p, are as defined as in formula I, or, salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.

Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.

Abstract: The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

Abstract: The present invention relates to new compounds of formula I, 1

Abstract: The present invention relates to new compounds of formula I, 1

Abstract: The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

Abstract: The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

Abstract: More specifically, the present invention features an improved feeder tube for a water treatment cartridge that provides treatment by a solid compound for a slipstream of untreated water flowing through the cartridge. The feeder tube includes a first end and a second end, such that the slipstream of water generally flows into the feeder tube at the second end and out of the feeder tube at the first end. A bottom plug assembly is in operational relationship with the second end and includes a porous plug being sized and configured to provide filtration and purification for the slipstream portion of the water.

Abstract: A button for providing a physical and sealing connection between a septum and an outlet stack of a water treatment cartridge having an opening. The button includes a first end, a second end opposite the first end, and a central portion which connects the first end to the second end. Located on the first end, there is a plurality of flexible locking members, configured for being inserted into the opening. To attach the button to the outlet stack, the locking members lockingly engage the outlet stack. The central portion has an annular groove provided with an O-ring. The O-ring facilitates a sealed connection between the button and the outlet stack. The button is connected to the septum by the use of either a washer and nonsolvent glue or heat staking.

Abstract: A ground anchor with a floating stabilizer consists of an elongate shaft, a screw flight coupled to the shaft at the lower end and an extension point mounted to the shaft at its lowermost point. A drive handle is provided for rotating the shaft about the axis and threading the flight into the ground. A winged stabilizer member fits over the shaft such that it floats freely of the shaft after installation to accommodate ground heave. An L-shaped mounting member is carried on a threaded rod screwed into a female thread at the top of the shaft for engaging a structure and supporting the structure relative to the ground.

Abstract: The invention provides a method of synthesizing N-substituted 1,4-piperazines and N-substituted 1,4-piperazinediones. The invention also provides a method for synthesing combinatorial libraries of piperazine derivatives which can be assayed for biological activity in pre-specified ligand binding or enzymatic activity screens.

Abstract: The present invention describes a method for inhibiting the polymerization of unsaturated silanes by the addition of a non-aromatic stable free radical during any of the steps of the formation of the desired silane, the purification of the desired silane, and to the desired silanes, as well as compositions of the inhibitors and the silanes. Particular classes of silanes to be inhibited include acryloxy-, methacryloxy-, and vinyl- functional silanes. The free radicals for use as inhibitors include various nitroxides. The free radicals taught herein are effective as inhibitors at elevated temperatures, for extended periods of time, and even in the absence of molecular oxygen.

Abstract: Flexible composites, such as those useful as light pipes, may be effectively cured by reactions upon copolymerized alkoxysilane functionality. Improvements in the optical properties of the uncured and cured systems are found when the alkoxysilane monomer is stabilized during preparation, storage, and copolymerization with low levels of non-aromatic stable free radicals or stable free-radical precursors, such as nitroxides.

Abstract: The present invention provides methods of detecting and suppressing an undesired immune response, and agents suitable for use therein. More specifically, the present invention, provides agents and methods for their use, directed at detecting and suppressing an undesired immune response to compositions containing sulfamethoxazole.

Abstract: A moisture sensing element is disclosed which comprises an electrically continuous article comprising an inorganic crystalline composition selected from the group consisting of zeolite molecular sieves in which the molar ratio of silica to alumina is greater than 6, silica molecular sieves, non-zeolitic molecular sieves and mixtures thereof; and two electrodes affixed to the article at different locations in current carrying relationship so that the current between the two electrodes passes through at least a portion of the inorganic crystalline composition.