Patents by Inventor Donald A. Raible

Donald A. Raible has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210317220
    Abstract: Methods for clinically proven safe administration of an anti-CD 154 antibody or antigen binding fragment thereof by subcutaneous or intravenous administration are provided. Also provided are methods for clinically proven safe treatment of an autoimmune disease by subcutaneous or intravenous administration of an anti-CD 154 antibody or antigen binding fragment thereof, such as rheumatoid arthritis, systemic lupus erythematosus (SLE), and Sjögren's Syndrome.
    Type: Application
    Filed: September 24, 2019
    Publication date: October 14, 2021
    Applicant: Janssen Biotech, Inc.
    Inventors: Mark RIGBY, Donald RAIBLE, Alexa PIANTONE, Jocelyn LEU, Nina Chi Sabins
  • Publication number: 20200121588
    Abstract: Provided are methods of subcutaneous administration of anti-CD38 monoclonal antibodies, such as daratumumab. Also provided are methods for the treatment of autoimmune diseases with subcutaneously administered anti-CD38 monoclonal antibodies. A corticosteroid is optionally administered prior to subcutaneous administration of the anti-CD38 antibody to prevent and/or reduce systemic injection related side effects.
    Type: Application
    Filed: October 17, 2019
    Publication date: April 23, 2020
    Inventors: Kim Anne Campbell, Ivo Nnane, Donald Raible, Cathye Shu, Zhenhua Xu
  • Publication number: 20170198049
    Abstract: Provided herein is are methods of reducing exacerbations of asthma in an asthma patient, comprising administering to the patient an effective amount of the anti-interleukin-5 receptor (IL-5R) antibody benralizumab or an antigen-binding fragment thereof.
    Type: Application
    Filed: September 2, 2016
    Publication date: July 13, 2017
    Inventors: Christine Ward, Lorin Roskos, Bing Wang, Donald Raible
  • Patent number: 9441047
    Abstract: Provided herein are methods of improving asthma symptoms, e.g., as measured by an asthma control questionnaire, comprising administering to the patient an effective amount of benralizumab or an antigen-binding fragment thereof.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: September 13, 2016
    Assignee: ASTRAZENECA AB
    Inventors: Christine Ward, Lorin Roskos, Bing Wang, Donald Raible
  • Patent number: 9441046
    Abstract: Provided herein is are methods of increasing forced expiratory volume in one second (FEV1) in an asthma patient, comprising administering to the patient an effective amount of benralizumab or an antigen-binding fragment thereof.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: September 13, 2016
    Assignee: ASTRAZENECA AB
    Inventors: Christine Ward, Lorin Roskos, Bing Wang, Donald Raible
  • Patent number: 9441037
    Abstract: Provided herein is are methods of reducing exacerbations of asthma in an asthma patient, comprising administering to the patient an effective amount of the anti-interleukin-5 receptor (IL-5R) antibody benralizumab or an antigen-binding fragment thereof.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: September 13, 2016
    Assignee: ASTRAZENECA AB
    Inventors: Christine Ward, Lorin Roskos, Bing Wang, Donald Raible
  • Publication number: 20150044204
    Abstract: Provided herein are methods of improving asthma symptoms, e.g., as measured by an asthma control questionnaire, comprising administering to the patient an effective amount of benralizumab or an antigen-binding fragment thereof.
    Type: Application
    Filed: August 7, 2014
    Publication date: February 12, 2015
    Inventors: Christine Ward, Lorin Roskos, Bing Wang, Donald Raible
  • Publication number: 20150044203
    Abstract: Provided herein is are methods of increasing forced expiratory volume in one second (FEV1) in an asthma patient, comprising administering to the patient an effective amount of benralizumab or an antigen-binding fragment thereof.
    Type: Application
    Filed: August 7, 2014
    Publication date: February 12, 2015
    Inventors: Christine Ward, Lorin Roskos, Bing Wang, Donald Raible
  • Publication number: 20150044202
    Abstract: Provided herein is are methods of reducing exacerbations of asthma in an asthma patient, comprising administering to the patient an effective amount of the anti-interleukin-5 receptor (IL-5R) antibody benralizumab or an antigen-binding fragment thereof.
    Type: Application
    Filed: August 7, 2014
    Publication date: February 12, 2015
    Inventors: Christine Ward, Lorin Roskos, Bing Wang, Donald Raible
  • Publication number: 20060270638
    Abstract: The present disclosure is directed to combination therapies of tigecycline and warfarin and methods of administration of tigecycline and warfarin.
    Type: Application
    Filed: May 5, 2006
    Publication date: November 30, 2006
    Applicant: Wyeth
    Inventors: John Speth, Dawn Harper, Donald Raible, Gopal Muralidharan
  • Publication number: 20060094668
    Abstract: The invention pertains to treatment of bacterial infections with tigecycline and cardiac insufficiency with digoxin by coadministration to a human in need thereof.
    Type: Application
    Filed: October 28, 2005
    Publication date: May 4, 2006
    Applicant: Wyeth
    Inventors: Donald Raible, Gopal Muralidharan
  • Patent number: 6162017
    Abstract: A stand alone blood pump which can be used with different types of oxygenators or extra corporeal circuits during surgery. After use the pump is easily detachable from its drive motor to enable a new blood pump to be mounted for the next operation. The pump impeller includes vanes at the base which extend at an angle to the plane of rotation and smoothly merge along a common plane with a plurality of helical fingers respectively. The width of the helical fingers gradually diminishes from the vanes to their extremities which are angularly spaced from each other at the pump inlet. The helical fingers flow the blood helically about the impeller axis to the vanes which then centrifugally flow the blood to the pump outlet tangentially of the pump housing.
    Type: Grant
    Filed: April 14, 1999
    Date of Patent: December 19, 2000
    Assignee: Cardiovascular Innovations LLC
    Inventor: Donald A. Raible
  • Patent number: 5770149
    Abstract: An extracorporeal blood oxygenation system comprising an integrated blood pump/heat exchanger/membrane oxygenator assembly which is mountable upon, and engageable with, a separate motor/drive assembly. The blood pump of the system incorporates a novel axial/centrifugal impeller assembly. An optional blood reservoir may be incorporated into the system to receive and contain venous return and/or surgical site blood. Also, an optional arterial filter may be incorporated into the system for filtering the oxygenated blood before the blood is returned to the patient. The pump/heat exchanger/membrane oxygenator component is preferably constructed such that heat exchange fluid which is being infused into the heat exchanger will pass through and/or in contact with a portion of the membrane oxygenator so as to further maintain the temperature of blood as it passes through the membrane oxygenator.
    Type: Grant
    Filed: October 31, 1995
    Date of Patent: June 23, 1998
    Assignee: Baxter International
    Inventor: Donald A. Raible
  • Patent number: 5501574
    Abstract: A dynamic blood pump includes a rotating core member and rotating ring portion effective to pre-spin blood before the blood enteres helical pumping channels of the pump. The blood is pumped and further rotated as it moves axially along the helical channels toward a centrifugal section of the pump. At the centrifugal pumping section circumferential velocity differentials are also controlled to diminish damage to the blood. Outwardly of the centrifugal pumping section, a forced-vortex pumping section communicates the pumped blood to an exit port.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: March 26, 1996
    Assignee: Baxter International Inc.
    Inventor: Donald A. Raible
  • Patent number: 5368438
    Abstract: A dynamic blood pump includes a rotating core member and rotating ring portion effective to pre-spin blood before the blood enteres helical pumping channels of the pump. The blood is pumped and further rotated as it moves axially along the helical channels toward a centrifugal section of the pump. At the centrifugal pumping section circumferential velocity differentials are also controlled to diminish damage to the blood. Outwardly of the centrifugal pumping section, a forced-vortex pumping section communicates the pumped blood to an exit port.
    Type: Grant
    Filed: June 28, 1993
    Date of Patent: November 29, 1994
    Assignee: Baxter International Inc.
    Inventor: Donald A. Raible
  • Patent number: 5270005
    Abstract: An extracorporeal blood oxygenation system comprising an integral blood processing unit having a blood reservoir/oxygenator/heat exchanger/pump and pump motor and a remote control console connectable to the integral blood processing unit by way of non-blood containing connections such as electrical cable or the like.
    Type: Grant
    Filed: June 29, 1992
    Date of Patent: December 14, 1993
    Assignee: Baxter International Inc.
    Inventor: Donald A. Raible
  • Patent number: 5266265
    Abstract: A blood oxygenator/heat exchanger system includes disposable and durable components, the latter being possible of permanent installation to further reduce costs, inconvenience and risks of use. The system may selectively include a blood pump of axial, centrifugal, or ventricular type, along with an integral venous reservoir. By combination, arrangement and cooperation of structural features blood pumping volume is decreased, advantageous blood flow paths are achieved, blood damage is reduced, and durable components are reusable for lowest costs. The oxygenator/heat exchanger nests upon a durable heat source base to be supported thereby, while redundant boundaries are provided between blood and heat transfer media.
    Type: Grant
    Filed: October 8, 1992
    Date of Patent: November 30, 1993
    Assignee: Baxter International, Inc.
    Inventor: Donald A. Raible
  • Patent number: 5217689
    Abstract: A blood oxygenation system includes an oxygenator for oxygenating blood and a heat exchanger for regulating blood temperature. The heat exchanger includes a heat exchange coil that provides a flow path for a heat exchange media, the heat exchange coil is configured to define a heat exchange zone, and the oxygenator is disposed in heat transfer relationship with the heat exchange zone in order to transfer heat between the heat exchange coil and the oxygenator. The heat exchange coil may at least partially circumscribe the oxygenator and, preferably, be helically shaped and disposed coaxially over a membrane oxygenator. In one embodiment, single or multiple hollow fiber strands are wound onto a small diameter center core so that the fiber segments provide spiralling helical blood-flow pathways which increase oxygen/carbon dioxide exchange by secondary flow paths.
    Type: Grant
    Filed: October 26, 1989
    Date of Patent: June 8, 1993
    Assignee: Baxter International Inc.
    Inventor: Donald A. Raible
  • Patent number: 5186713
    Abstract: A method, device and system for providing a flow of oxygenated perfusion fluid (e.g. oxygenated whole blood) through a balloon angioplasty catheter to perfuse tissues which would normally be deprived of blood flow when the balloon of the angioplasty catheter is inflated. In accordance with the invention, an extracorporeal membrane oxygenation device is fluidly connected to the angioplasty catheter such that oxygenated fluid (e.g. oxygenated whole blood) may be passed through the catheter and caused to exit the catheter distal to the angioplasty balloon. The patient's own blood may be withdrawn, oxygenated by the extracorporeal membrane oxygenation device and subsequently reinfused through the angioplasty catheter. A dual-lumen introducer sheath may be employed for the dual function of a) facilitating insertion of the catheter and b) allowing withdrawal of blood for subsequent oxygenation and reinfusion through the angioplasty catheter.
    Type: Grant
    Filed: November 1, 1990
    Date of Patent: February 16, 1993
    Assignee: Baxter International Inc.
    Inventor: Donald A. Raible
  • Patent number: D427610
    Type: Grant
    Filed: June 7, 1999
    Date of Patent: July 4, 2000
    Inventor: Donald A. Raible