Patents by Inventor Donald Arthur Masquelier
Donald Arthur Masquelier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9623384Abstract: System, including apparatus and methods, for performing droplet-based assays. The system may comprise a droplet transporter configured to pick up droplets from each emulsion of an array of reacted emulsions and to drive flow of the droplets through a detection region. The system also may comprise a detector configured to collect data related to one or more analytes from individual droplets of the reacted emulsions as such individual droplets travel through the detection region. The system further may comprise a controller programmed to determine, based on the data collected, an aspect of the one or more analytes in one or more samples included in droplets of the emulsions.Type: GrantFiled: December 7, 2010Date of Patent: April 18, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Benjamin Joseph Hindson, Kevin Dean Ness, Billy Wayne Colston, Jr., Fred Paul Milanovich, Donald Arthur Masquelier, Anthony Joseph Makarewicz, Jr.
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Patent number: 9248417Abstract: System, including method and apparatus, for performing droplet-based assays. In the method, an emulsion may be obtained that includes droplets packed closely together in a three-dimensional packing arrangement. Data related to an analyte may be collected from individual droplets of the reacted emulsion as such droplets travel serially through a detection region.Type: GrantFiled: December 7, 2010Date of Patent: February 2, 2016Assignee: Bio-Rad Laboratories, Inc.Inventors: Benjamin Joseph Hindson, Kevin Dean Ness, Billy Wayne Colston, Jr., Fred Paul Milanovich, Donald Arthur Masquelier, Anthony Joseph Makarewicz, Jr.
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Patent number: 9216392Abstract: System, including apparatus and methods, for forming an array of emulsions. The system may comprise a plate including an array of emulsion production units. Each unit may include at least one first input well, a second input well, and an output well connected to the first and second input wells by channels that form a droplet generator. The system also may comprise a vacuum or pressure source configured to be connected operatively to wells of the plate to form a pressure drop between the input wells and the output well of each unit that is capable of driving a first fluid and a second fluid from respective first and second input wells of such unit and through the droplet generator, for collection as an emulsion in the output well of such unit.Type: GrantFiled: December 7, 2010Date of Patent: December 22, 2015Assignee: Bio-Rad Laboratories, Inc.Inventors: Benjamin Joseph Hindson, Kevin Dean Ness, Billy Wayne Colston, Jr., Fred Paul Milanovich, Donald Arthur Masquelier, Anthony Joseph Makarewicz, Jr.
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Patent number: 9156010Abstract: Systems, including apparatus and methods, for performing assays. These systems may involve separating sample components by partitioning them into droplets or other partitions, amplifying or otherwise reacting the components within the droplets, detecting the amplified components, or characteristics thereof, and/or analyzing the resulting data, among others.Type: GrantFiled: September 23, 2009Date of Patent: October 13, 2015Assignee: Bio-Rad Laboratories, Inc.Inventors: Billy Wayne Colston, Jr., Benjamin Joseph Hindson, Kevin Dean Ness, Donald Arthur Masquelier, Fred Paul Milanovich, Douglas N. Modlin, Vincent Riot, Samuel Burd, Anthony Joseph Makarewicz, Jr., Phillip Belgrader
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Publication number: 20120021423Abstract: System, including methods and apparatus, for performing droplet-based tests of nucleic acid amplification that are controlled and/or calibrated using signals detected from droplets.Type: ApplicationFiled: September 26, 2011Publication date: January 26, 2012Applicant: QuantaLife, Inc.Inventors: Billy Wayne Colston, JR., Benjamin Joseph Hindson, Kevin Dean Ness, Donald Arthur Masquelier
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Publication number: 20110092392Abstract: System, including apparatus and methods, for forming an array of emulsions. The system may comprise a plate including an array of emulsion production units. Each unit may include at least one first input well, a second input well, and an output well connected to the first and second input wells by channels that form a droplet generator. The system also may comprise a vacuum or pressure source configured to be connected operatively to wells of the plate to form a pressure drop between the input wells and the output well of each unit that is capable of driving a first fluid and a second fluid from respective first and second input wells of such unit and through the droplet generator, for collection as an emulsion in the output well of such unit.Type: ApplicationFiled: December 7, 2010Publication date: April 21, 2011Applicant: QUANTALIFE, INC.Inventors: Billy Wayne Colston, JR., Donald Arthur Masquelier, Kevin Dean Ness, Anthony Joseph Makarewicz, JR., Benjamin Joseph Hindson, Fred Paul Milanovich
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Publication number: 20110092373Abstract: System, including apparatus and methods, for performing droplet-based assays. The system may comprise a droplet transporter configured to pick up droplets from each emulsion of an array of reacted emulsions and to drive flow of the droplets through a detection region. The system also may comprise a detector configured to collect data related to one or more analytes from individual droplets of the reacted emulsions as such individual droplets travel through the detection region. The system further may comprise a controller programmed to determine, based on the data collected, an aspect of the one or more analytes in one or more samples included in droplets of the emulsions.Type: ApplicationFiled: December 7, 2010Publication date: April 21, 2011Applicant: QUANTALIFE, INC.Inventors: Billy Wayne Colston, JR., Donald Arthur Masquelier, Kevin Dean Ness, Anthony Joseph Makarewicz, JR., Benjamin Joseph Hindson, Fred Paul Milanovich
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Publication number: 20110092376Abstract: System, including method and apparatus, for performing droplet-based assays. In the method, an emulsion may be obtained that includes droplets packed closely together in a three-dimensional packing arrangement. Data related to an analyte may be collected from individual droplets of the reacted emulsion as such droplets travel serially through a detection region.Type: ApplicationFiled: December 7, 2010Publication date: April 21, 2011Applicant: QUANTALIFE, INC.Inventors: Billy Wayne Colston, JR., Donald Arthur Masquelier, Kevin Dean Ness, Anthony Joseph Makarewicz, JR., Benjamin Joseph Hindson, Fred Paul Milanovich
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Publication number: 20110086780Abstract: A system, including method and apparatus, for forming an array of emulsions. The system may include a plate providing an array of emulsion production units each configured to produce a separate emulsion and each including a set of wells interconnected by channels that intersect to form a site of droplet generation. Each set of wells, in turn, may include (1) at least one first input well to receive a continuous phase, (2) a second input well to receive a dispersed phase, and (3) an output well configured to receive from the site of droplet generation an emulsion of droplets of the dispersed phase disposed in the continuous phase.Type: ApplicationFiled: December 8, 2010Publication date: April 14, 2011Applicant: QUANTALIFE, INC.Inventors: Billy Wyne Colston, JR., Benjamin Joseph Hindson, Kevin Dean Ness, Donald Arthur Masquelier
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Publication number: 20100173394Abstract: Systems, including apparatus and methods, for performing assays. These systems may involve separating sample components by partitioning them into droplets or other partitions, amplifying or otherwise reacting the components within the droplets, detecting the amplified components, or characteristics thereof, and/or analyzing the resulting data, among others.Type: ApplicationFiled: September 23, 2009Publication date: July 8, 2010Inventors: Billy Wayne Colston, JR., Benjamin Joseph Hindson, Kevin Dean Ness, Donald Arthur Masquelier, Fred Paul Milanovich, Douglas N. Modlin, Vincent Riot, Samuel Burd, Anthony Joseph Makarewicz, JR., Phillip Belgrader