Publication number: 20070060618
Abstract: The present invention is directed to isotopically labeled alkyne derivative compounds, particularly 11C, 13C, 14C, 18F, 15O, 13N, 35S, 2H, and 3H labeled compounds. In particular, the present invention is directed to 11C, 13C, 14C, 18F, 15O, 13N, 35S, 2H, and 3H labeled heterocyclic alkynes and methods of their preparation. The present invention further includes a method of use of the 11C, 18F, 15O, or 13N labeled heterocyclic alkyne compounds as tracers in positron emission tomography (PET) imaging, particularly in the study of metabolic conditions in mammals, specifically conditions modulated by metabotropic glutamate receptors subtype 5 (mGluR5).
Type:
Application
Filed:
October 24, 2003
Publication date:
March 15, 2007
Applicant:
MERCK & CO., INC.
Inventors:
Nicholas David Cosford, Steven Govck, Terence Hamill, Theodore Kamenecka, Thomas Seiders, Jeffrey Roppe, Celine Bonnefous, Donald Burns, Matthew Braun, Dennis Dean, Joseph Simeone