Abstract: A training device (10) for training a user in the operation of an auto-injector that dispenses a medicament is described. The training device (10) comprises a housing (13), an actuation assembly (22) located within the housing (13), the actuation assembly (22) comprising a plunger (24) and a guide member (26), the plunger and the guide member defining, and connected by, a complementary first male profile and a first female profile. The plunger (24) is movable with respect to the guide member (26) along a first path defined by at least a portion of the first male or the first female profiles, the plunger (24) moving linearly between a start position and a finish position. The first path extends in a direction non-parallel to the linear movement of the plunger (24).

Abstract: The invention hereindescribed relates to a form of cancer therapy which exploits the cytotoxic properties of acetaminophen when converted to NABQI by the metabolic activity of tumour cell specific P450; vectors for use in the delivery of P450 to tumour cells; and therapeutic compositions comprising said vectors.

Abstract: The invention relates to a method of gene directed enzyme pro-drug therapy (GDEPT) in the ablation of cells wherein said cells are not cancerous cells.

Abstract: A lateral shearing interferometer wavefront sensor system (10) that employs a double-shear/full aperture approach to correct for branch points in the wavefront of an optical beam (24) that has been aberated. The wavefront sensor system (10) includes a lateral shearing interferometer (12) having a beam splitter (14) that splits the beam (24) into a first split beam (28) and a second split beam (26), a beam shifter (22) that shifts the first split beam (28) relative to the second split beam (26), and a beam combiner (16) that combines first shifted split beam (28) and the second split beam (26) into a combined beam (30). The combined beam (30) provides an interference pattern that includes a plurality of interfered beam portions (76, 78, 82, 84). A deformable mirror (72) includes a plurality of actuators (74) which deform the mirror (72) to correct the beam wavefront.

Abstract: A method of treating a patient having a highly vascular tumor includes administering a therapeutically effective amount of dextrin sulphate to the patient. The highly vascular tumor can be, for example, Kaposi's sarcoma. The treatment results in regression of the tumors and the improvement persists for a considerable time after completion of the treatment.