Patents by Inventor Donald Durden

Donald Durden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Asparaginase and treating diseases associated with asparagine dependence
    Patent number: 9051561
    Abstract: Disclosed herein are polypeptides which exhibit asparaginase activity and little to no glutaminase activity. The polypeptides have sequences which correspond to W. succinogenes asparaginase, but have an amino acid residue other than proline at amino acid position 121. The polypeptides exhibit higher kinetic rates of asparaginase activity to glutaminase activity as compared to W. succinogenes asparaginase and Elspar®, an E. coli asparaginase.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: June 9, 2015
    Assignee: Children's Hospital Los Angeles
    Inventor: Donald Durden
  • Pten Inhibitors
    Publication number: 20070203098
    Abstract: The therapeutic use of inhibitors of PTEN activity in the treatment of PTEN-mediated diseases, conditions, and injuries is disclosed.
    Type: Application
    Filed: April 6, 2005
    Publication date: August 30, 2007
    Applicant: Semafore Pharmaceuticals, Inc.
    Inventors: Joseph Garlich, Donald Durden, Taxiarchis Georgiadis, Jingdong Su, Xiaodong Peng, Tim Smith
  • PI-3 kinase inhibitor prodrugs
    Publication number: 20050203173
    Abstract: The invention provides novel prodrugs of inhibitors of PI-3 kinase. The novel compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine.
    Type: Application
    Filed: April 20, 2005
    Publication date: September 15, 2005
    Inventors: Joseph Garlich, Donald Durden, Mary Patterson, Jingdong Su, Robert Suhr
  • Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways
    Publication number: 20050032727
    Abstract: Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling.
    Type: Application
    Filed: November 13, 2003
    Publication date: February 10, 2005
    Inventor: Donald Durden