Patents by Inventor Donald E. Butler

Donald E. Butler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivatives of N-[2-(tetrahydro-3,5-dioxo-1H-pyrrolizin-7a(5H)-yl)ethyl]amine as cognition activators
    Patent number: 4563469
    Abstract: Novel derivatives of N-[2-(tetrahydro-3,5-dioxo-1H-pyrrolizin-7a(5H)-yl)ethyl]amine are effective as cognition activators for reversing the effects of electroshock induced amnesia. A method of preparing the compounds, a useful intermediate in their preparation, pharmaceutical compositions, and a method of treatment are also disclosed.
    Type: Grant
    Filed: July 20, 1984
    Date of Patent: January 7, 1986
    Assignee: Warner-Lambert Company
    Inventors: Donald E. Butler, James D. Leonard
  • Reversing amnesia with saturated tricyclic nitrogen-containing diones
    Patent number: 4562195
    Abstract: A class of novel saturated, fused-ring, tricyclic, nitrogen-containing diones are useful as agents in treating electro-convulsive shock-induced amnesia. A method of preparing the compounds, pharmaceutical compositions including the compounds, and a method of treating amnesia are disclosed.
    Type: Grant
    Filed: January 7, 1985
    Date of Patent: December 31, 1985
    Assignee: Warner-Lambert Company
    Inventors: Donald E. Butler, Yvon J. L'Italien
  • 5-Oxo-2-pyrrolidinepropanoic acid and derivatives for reversing electroshock amnesia
    Patent number: 4559358
    Abstract: 5-Oxo-2-pyrrolidinepropanoic acids, base addition salts, esters and amides are useful as agents for the reversal of amnesia. Pharmaceutical compositions containing said compounds and methods for using said compositions for treating senility and reversal of amnesia are also taught.
    Type: Grant
    Filed: March 24, 1983
    Date of Patent: December 17, 1985
    Assignee: Warner-Lambert Company
    Inventor: Donald E. Butler
  • Hexahydro-3,5-dioxo-1H-pyrrolizine-2-carboxylic acid and derivatives, and use for reversing electroconvulsive shock amnesia
    Patent number: 4551470
    Abstract: Hexahydro-3,5-dioxo-1H-pyrrolizine-2-carboxylic acid, its esters, ammonium, metal, and organic amine salts are useful for the treatment of senility, for enhancing memory, and for reversing electroconvulsive shock induced amnesia in humans. Pharmaceutical compositions including these compounds, and a method of treatment employing these pharmaceutical compositions is disclosed.
    Type: Grant
    Filed: August 29, 1983
    Date of Patent: November 5, 1985
    Assignee: Warner-Lambert Company
    Inventor: Donald E. Butler
  • 1-(Substituted-aryl)-dihydro-1H-pyrrolizine-3,5-[2H,6H-]diones and use for reversing amnesia
    Patent number: 4548947
    Abstract: 1-(Substituted-aryl)-dihydro-1H-pyrrolizine-3,5-[2H,6H]-diones are effective cognition activating agents for the treatment of senility and for reversing amnesia. Pharmaceutical compositions containing these compounds and a method of treating senility or of reversing amnesia are also disclosed.
    Type: Grant
    Filed: May 7, 1984
    Date of Patent: October 22, 1985
    Assignee: Warner-Lambert Company
    Inventors: Donald E. Butler, Anthony J. Thomas
  • Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-carboxylic acid and benzyl esters and amides thereof and their use in reversing amnesia
    Patent number: 4547519
    Abstract: Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-alkanoic acids, base addition salts, esters, and amides are useful as agents for the reversal of amnesia. Pharmaceutical compositions containing said compounds and methods for using said compositions for treating senility and reversal of amnesia are also taught.
    Type: Grant
    Filed: February 9, 1983
    Date of Patent: October 15, 1985
    Assignee: Warner-Lambert Company
    Inventor: Donald E. Butler
  • Benzotricyclic nitrogen-containing diones and their use in reversing electroconvulsive shock-induced amnesia
    Patent number: 4530929
    Abstract: A class of novel fused-ring, benzotricyclic, nitrogen-containing diones useful as agents in reversing electroconvulsive shock-induced amnesia. A method of preparing the compounds, pharmaceutical compositions including the compounds, and a method of reversing electroconvulsive shock-induced amnesia are disclosed.
    Type: Grant
    Filed: February 2, 1984
    Date of Patent: July 23, 1985
    Assignee: Warner-Lambert Company
    Inventors: Donald E. Butler, Michael R. Pavia, Fred M. Hershenson
  • N-[1-oxo-3-(5-oxo-2-pyrrolidinyl)propyl]-alpha-aminoacids and derivatives as cognition activators
    Patent number: 4525476
    Abstract: N-[1-oxo-3-(5-oxo-2-pyrrolidinyl)propyl]-alpha-aminoacids, base addition salts, esters, and amides are useful as cognition activators. Pharmaceutical compositions containing these compounds and methods of using the pharmaceutical compositions for treating senility or amnesia are also disclosed.
    Type: Grant
    Filed: May 26, 1983
    Date of Patent: June 25, 1985
    Assignee: Warner-Lambert Company
    Inventors: Donald E. Butler, Fred M. Hershenson, Michael R. Pavia
  • 5-Oxo-2,2-pyrrolidinedipropanoic acid and ester derivatives thereof
    Patent number: 4454327
    Abstract: 5-oxo-2,2-pyrrolidinedipropanoic acid, base addition salts and esters are useful as agents for the reversal of amnesia. Intermediates for preparing said compounds, pharmaceutical compositions containing said compounds and methods for using said pharmaceutical compositions for treating senility and reversal of amnesia are also taught.
    Type: Grant
    Filed: May 24, 1982
    Date of Patent: June 12, 1984
    Assignee: Warner-Lambert Company
    Inventor: Donald E. Butler
  • 1-Aroyl-5-oxo-2-pyrrolidinepropanoic acids and related esters
    Patent number: 4452990
    Abstract: 1-Aroyl-5-oxo-2-pyrrolidinepropanoic acids, salts, and esters which are useful as pharmacological agents, especially as agents for the reversal of amnesia, enhancing performance in poorly motivated subjects and treatment of senility and methods for their preparations are disclosed. Pharmaceutical compositions containing said compounds, salts, and esters and methods for using said compositions in treating senility, improving motivation and reversal of amnesia are also taught.
    Type: Grant
    Filed: November 15, 1982
    Date of Patent: June 5, 1984
    Assignee: Warner-Lambert Company
    Inventor: Donald E. Butler
  • Pharmaceutical compositions and methods
    Patent number: 4434169
    Abstract: Oral pharmaceutical compositions comprising microdoses of 3-phenoxypyridine or pharmaceutically acceptable acid-addition salts thereof and a pharmaceutical carrier. Methods for treating hippocampal dysfunctions by administering microdoses of 3-phenoxypyridine or a pharmaceutically acceptable acid-addition salt thereof.
    Type: Grant
    Filed: January 3, 1983
    Date of Patent: February 28, 1984
    Assignee: Warner-Lambert Company
    Inventors: Bruno P. H. Poschel, Donald E. Butler
  • 4-Lower alkyl-3-phenoxypyridine-1-oxide and a method for its production
    Patent number: 4386094
    Abstract: 4-Lower alkyl-3-phenoxypyridine-1-oxides, pharmacological agents possessing anticonvulsant properties, pharmaceutical compositions and methods of using said compositions are disclosed. These compounds are produced by reacting 4-lower alkyl-3-phenoxypyridines with an oxidizing agent.
    Type: Grant
    Filed: August 18, 1980
    Date of Patent: May 31, 1983
    Assignee: Warner-Lambert Company
    Inventors: Donald E. Butler, Ivan C. Nordin
  • Use of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione as a cognition activator
    Patent number: 4372966
    Abstract: Dihydro-1H-pyrrolizine-3,5(2H,6H)-dione is a cognition activator. The compound and compositions thereof are useful in the treatment of senility, in enhancing memory and reversing amnesia caused by electroconvulsive shock.
    Type: Grant
    Filed: August 7, 1981
    Date of Patent: February 8, 1983
    Assignee: Warner-Lambert Company
    Inventor: Donald E. Butler
  • 3-(3-Substituted aryloxy)-2-yridinecarbonitriles, pharmaceutical compositions and methods for their production
    Patent number: 4229457
    Abstract: New 3-(3-methoxyphenoxy)-2-pyridinecarbonitriles, which are useful as pharmacological agents, especially as agents for the treatment of senility and reversal of amnesia, are disclosed. Other known 3-(3-substituted phenoxy)-2-pyridinecarbonitriles are disclosed having the same utility. The compounds can be produced by dehydrating the appropriately substituted oxime or displacing an alkoxy group to give the desired carbonitrile.
    Type: Grant
    Filed: September 27, 1979
    Date of Patent: October 21, 1980
    Assignee: Warner-Lambert Company
    Inventor: Donald E. Butler
  • 5-Phenoxy-2-pyridinecarbonitrile compounds and methods for their production
    Patent number: 4212980
    Abstract: 5-phenoxy-2-pyridinecarbonitrile compounds, which are useful as pharmacological agents, especially as agents for the reversal of amnesia, and methods for their preparation are disclosed. Pharmaceutical compositions containing said compounds and methods for using said compositions in treating senility and reversal of amnesia are also taught.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: July 15, 1980
    Assignee: Warner-Lambert Company
    Inventor: Donald E. Butler
  • 3-Aryloxy-1-carboalkoxyethylpyridinium compounds and compositions
    Patent number: 4187311
    Abstract: 3-Aryloxy-1-carboalkoxyethylpyridinium compounds, which are useful as pharmacological agents, especially as agents for the treatment of senility and reversal of amnesia, are disclosed. The compounds can be produced by reacting 3-aryloxypyridine with an alkyl acetate containing a displaceable group.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: February 5, 1980
    Assignee: Warner-Lambert Company
    Inventor: Donald E. Butler
  • 3-Aryloxy-2-pyridinecarbonitrile 1-oxide compounds
    Patent number: 4187379
    Abstract: 3-Aryloxy-2-pyridinecarbonitrile 1-oxide compounds, which are useful as pharmacological agents, especially as agents for the reversal of amnesia, are disclosed. The compounds can be produced by oxidizing a 3-aryloxy-2-pyridinecarbonitrile.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: February 5, 1980
    Assignee: Warner-Lambert Company
    Inventor: Donald E. Butler
  • New pyridobenzodioxin compounds and methods for their production
    Patent number: 4179506
    Abstract: Pyridobenzodioxin compounds, which are useful as pharmacological agents, especially as agents for the treatment of senility and reversal of amnesia, and methods for their preparation are disclosed. Pharmaceutical compositions containing said compounds and methods for using said compositions in treating senility and reversal of amnesia are also taught.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: December 18, 1979
    Assignee: Warner-Lambert Company
    Inventor: Donald E. Butler
  • 3-Aryloxy-substituted-aminopyridines and methods for their production
    Patent number: 4179563
    Abstract: 3-Aryloxy-substituted-aminopyridines and salts thereof, which are useful as pharmacological agents, especially cognition activators, are disclosed. They can be produced by reacting a chloro-3-aryloxypyridine with a substituted amine, 3-bromo-substituted-aminopyridine with an alkali metal salt of a phenol compound or by deoxygenation of a 3-aryloxy-substituted-aminopyridine N-oxide.
    Type: Grant
    Filed: May 19, 1978
    Date of Patent: December 18, 1979
    Assignee: Warner-Lambert Company
    Inventor: Donald E. Butler
  • 3-Phenoxypyridine monosulfate and a method for its production
    Patent number: 4128555
    Abstract: 3-Phenoxypyridine monosulfate, a pharmacological agent possessing mood elevating and cardiotonic properties. This compound is produced by reacting 3-phenoxypyridine with an equivalent amount of sulfuric acid.
    Type: Grant
    Filed: May 27, 1977
    Date of Patent: December 5, 1978
    Assignee: Warner-Lambert Company
    Inventor: Donald E. Butler