Patents by Inventor Donald E. Macfarlane

Donald E. Macfarlane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8706680
    Abstract: A computer system and database adapted to help with the synthesis and assembly of informational units (lexemes) required for the preparation of professional reports. The system works iteratively, and uses certain characteristics of professional reports to predict which lexemes a user is likely to need at each iteration, allowing the user to select the most useful lexemes from a very large number of lexemes stored in a lexicon for this purpose. The characteristics of professional reports that enable the process of selection include context, predicance and coherence. The report, consisting of an assembly of lexemes, can be exported as text files having different linguistic styles, or as computer code permitting efficient retrieval and computerized analysis of the content of the report for billing, administration, or research.
    Type: Grant
    Filed: April 5, 2005
    Date of Patent: April 22, 2014
    Inventor: Donald E. Macfarlane
  • Patent number: 7354711
    Abstract: The invention features methods for inhibiting immunostimulatory DNA-associated immune responses, through the administration of specific compounds of the general class of 9-aminoacridines and 4-aminoquiniolines. The invention also features methods of screening compounds useful in inhibiting immunostimulatory DNA-induced immune responses.
    Type: Grant
    Filed: January 3, 2003
    Date of Patent: April 8, 2008
    Assignees: University of Iowa Research Foundation, The Department of Veterans Affairs, as represented by the Secretary of United States of America
    Inventor: Donald E. Macfarlane
  • Publication number: 20030232856
    Abstract: The invention features methods for inhibiting immunostimulatory DNA-associated immune responses, through the administration of specific compounds of the general class of 9-aminoacridines and 4-aminoquiniolines. The invention also features methods of screening compounds useful in inhibiting immunostimulatory DNA-induced immune responses.
    Type: Application
    Filed: January 3, 2003
    Publication date: December 18, 2003
    Inventor: Donald E. MacFarlane
  • Patent number: 6521637
    Abstract: The invention features methods for inhibiting immunostimulatory DNA-associated immune responses, through the administration of specific compounds of the general class of 9-aminoacridines and 4-aminoquiniolines. The invention also features methods of screening compounds useful in inhibiting immunostimulatory DNA-induced immune responses.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: February 18, 2003
    Assignee: University of Iowa Research Foundation
    Inventor: Donald E. Macfarlane
  • Patent number: 6479504
    Abstract: The present invention relates generally to the field of immunology. More particularly it concerns compositions and methods for inhibiting stimulation of the immune system. The compounds and methods comprise compounds that are analogs and derivatives of chloroquine, such as 4-aminoquinolines, and other weak bases. They can be used in preventative and therapeutic treatments of autoimmune diseases and phenomena, transplant rejection such as host-versus-graft disease, and sepsis.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: November 12, 2002
    Assignees: The University of Iowa Research Foundation, Georgia State University Research Foundation, Inc., The United States of America as represented by the Department of Veterans Affairs
    Inventors: Donald E. Macfarlane, Lucjan Strekowski, Lori Manzel, Fyaz M. D. Ismail, Gordon B. Barlin
  • Publication number: 20020151564
    Abstract: The invention features methods for inhibiting immunostimulatory DNA-associated immune responses, through the administration of specific compounds of the general class of 9-aminoacridines and 4-aminoquiniolines. The invention also features methods of screening compounds useful in inhibiting immunostimulatory DNA-induced immune responses.
    Type: Application
    Filed: April 2, 2002
    Publication date: October 17, 2002
    Applicant: University of Iowa Research Foundation
    Inventor: Donald E. Macfarlane
  • Patent number: 6399630
    Abstract: The invention features methods for inhibiting immunostimulatory DNA-associated immune responses, through the administration of specific compounds of the general class of 9-aminoacridines and 4-aminoquinolines. The invention also features methods of screening compounds useful in inhibiting immunostimulatory DNA-induced immune responses.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: June 4, 2002
    Assignee: University of Iowa Research Foundation
    Inventor: Donald E. Macfarlane
  • Patent number: 6221882
    Abstract: The invention features methods for inhibiting immunostimulatory DNA-associated immune responses, through the administration of specific compounds of the general class of 9-aminoacridines and 4-aminoquiniolines. The invention also features methods of screening compounds useful in inhibiting immunostimulatory DNA-induced immune responses.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: April 24, 2001
    Assignee: University of Iowa Research Foundation
    Inventor: Donald E. Macfarlane
  • Patent number: 5985572
    Abstract: The present invention discloses a novel method for isolating RNA from biological samples using selected quaternary amine surfactants. The RNA is isolated quickly and in sufficient quantity and quality to permit analysis by methods including reverse transcriptase and polymerase chain reaction.
    Type: Grant
    Filed: February 23, 1998
    Date of Patent: November 16, 1999
    Assignee: Qiagen N.V.
    Inventor: Donald E. Macfarlane
  • Patent number: 5728822
    Abstract: The present invention discloses a novel method for isolating RNA from biological samples, most particularly blood, using selected quaternary amine surfactants. The RNA is isolated quickly and in sufficient quantity and quality to permit analysis by methods including reverse transcriptase and polymerase chain reaction.
    Type: Grant
    Filed: September 7, 1995
    Date of Patent: March 17, 1998
    Assignee: Qiagen N.V.
    Inventor: Donald E. Macfarlane
  • Patent number: 5300635
    Abstract: The present invention discloses a novel method for isolating nucleic acids from biological samples, most particularly blood, using selected quaternary amine surfactants. The nucleic acids are isolated quickly and in sufficient quantity and quality to permit analysis by methods including reverse transcriptase and polymerase chain reaction.
    Type: Grant
    Filed: February 1, 1993
    Date of Patent: April 5, 1994
    Assignee: University of Iowa Research Foundation
    Inventor: Donald E. Macfarlane
  • Patent number: 5010183
    Abstract: A novel method is provided for purifying DNA and RNA from a variety of sources, including cells, cell lysates, viruses, tissues, blood and other body fluids employing a cationic detergent to complex with the nucleic acids.
    Type: Grant
    Filed: July 7, 1989
    Date of Patent: April 23, 1991
    Inventor: Donald E. Macfarlane