Abstract: An improved process for the production of dialkoxy phosphoric acid esters of substituted hydroxypyrimidines which involves reacting a dialkyl phosphoric acid halide with a substituted hydroxypyrimidine reaction in a two-step reaction is disclosed. In reaction step (a) the hydroxypyrimidine derivative is converted with the aid of sodium hydroxide and in the presence of a hydrocarbon solvent and a phase-transfer catalyst to the sodium salt while drying the reaction mixture by azeotropically removing water. In step (b) the condensation process is carried out at room temperature to about 100.degree. C. The condensation step may be accelerated by addition of 4-bis(C.sub.1 to C.sub.4 alkyl)aminopyridine as catalyst.

Abstract: A process is provided for preparing methyliminoisobutyrate hydrochloride by reacting isobutyronitrile (IBN), hydrogen chloride (HCl) and methanol in the presence of excess HCl, wherein the IBN and HCl are added at a temperature from about 5.degree. C to about 25.degree. C to a methanolic solution containing excess HCl and by maintaining during the reaction a methanolic reaction medium saturated with HCl.

Abstract: Production of 2-alkyl or cycloalkyl-4-methyl-6-hydroxy-pyrimidines through a continuous ring closure/neutralization process which increases equipment capacity by a minimum of 45% and yield of about 10% over the usual batch process.