Patents by Inventor Donald F. Colella

Donald F. Colella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • .alpha.-AMINOMETHYL-4-HYDROXY-3-METHYLSULFONYL BENZYL ALCOHOLS
    Patent number: 4048229
    Abstract: .alpha.-Aminomethyl-4-hydroxy-3-methylsulfonyl benzyl alcohols having .beta.-adrenergic antagonist activity are prepared generally from 4-benzyloxy-3-methylsulfonylacetophenone by, for example, bromination and treatment of the resulting .alpha.-bromo derivative with an N-benzyl secondary amine, followed by catalytic hydrogenation to remove protective benzyl groups and reduce the ketone moiety.
    Type: Grant
    Filed: January 8, 1975
    Date of Patent: September 13, 1977
    Assignee: SmithKline Corporation
    Inventors: Donald F. Colella, Carl Kaiser
  • N,N-bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyethyl]-polymethylenediamines
    Patent number: 4024281
    Abstract: N,N'-Bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyethyl]-polymethylenediamines having .beta.-adrenergic stimulant activity particularly as selective bronchodilators, are prepared generally by condensation of an N-benzylphenethylamine with a polymethylene dihalide or by reaction of an .beta.-bromoacetophenone with an N,N'-dibenzyl-polymethylenediamine, with further operations depending on the nature of the 3-substituent, and subsequently hydrogenating catalytically with for example palladium-on-carbon. The key intermediates are also part of the invention.
    Type: Grant
    Filed: October 16, 1975
    Date of Patent: May 17, 1977
    Assignee: SmithKline Corporation
    Inventors: Donald F. Colella, Carl Kaiser
  • Bis-phenoxypropanolamines
    Patent number: 4013777
    Abstract: Bis-phenoxypropanolamine derivatives are prepared. These compounds have .beta.-adrenergic stimulant activity particularly as selective bronchodilators.
    Type: Grant
    Filed: August 22, 1975
    Date of Patent: March 22, 1977
    Assignee: SmithKline Corporation
    Inventors: Donald F. Colella, Carl Kaiser
  • 3-Alkylamino-.alpha.-aminomethyl-4-hydroxybenzyl alcohols with .beta.-adrenergic stimulant activity
    Patent number: 3996383
    Abstract: A series of 3-alkylamino-.alpha.-substituted aminomethyl-4-hydroxybenzyl alcohols are prepared. These compounds are .beta.-adrenergic stimulants, in particular as bronchodilators.
    Type: Grant
    Filed: November 12, 1975
    Date of Patent: December 7, 1976
    Assignee: SmithKline Corporation
    Inventors: Donald F. Colella, Carl Kaiser
  • 3-Alkylamino- alpha-aminomethyl-4-hydroxybenzyl alcohols
    Patent number: 3943173
    Abstract: A series of 3-alkylamino-.alpha.-substituted aminomethyl-4-hydroxybenzyl alcohols are prepared. These compounds are .beta.-adrenergic stimulants, in particular as bronchodilators.
    Type: Grant
    Filed: November 22, 1972
    Date of Patent: March 9, 1976
    Assignee: SmithKline Corporation
    Inventors: Donald F. Colella, Carl Kaiser
  • Beta-adrenergic antagonists
    Patent number: 3943254
    Abstract: .alpha.-Aminomethyl-4-hydroxy-3-sulfamylbenzyl alcohols and 4-hydroxy-3-sulfamylphenethylamines are disclosed. These compounds have .beta.-adrenergic antagonist activity.
    Type: Grant
    Filed: November 7, 1974
    Date of Patent: March 9, 1976
    Assignee: Smithkline Corporation
    Inventors: Donald F. Colella, Carl Kaiser
  • N,N'-bis[3-substituted-4-hydroxypheyl)-2-hydroxyethyl)] -polymethylenediamines
    Patent number: 3933913
    Abstract: N,N'-Bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or-2-hydroxyethyl]-polymethylenediamines having .beta.-adrenergic stimulant activity particularly as selective bronchodilators, are prepared generally by condensation of an N-benzylphenethylamine with a polymethylene dihalide or by reaction of an .alpha.-bromoacetophenone with an N,N'-dibenzyl-polymethylenediamine, with further operations depending on the nature of the 3-substituent, and subsequently hydrogenating catalytically with for example palladium-on-carbon. The key intermediates are also part of the invention.
    Type: Grant
    Filed: September 8, 1972
    Date of Patent: January 20, 1976
    Assignee: SmithKline Corporation
    Inventors: Donald F. Colella, Carl Kaiser