Abstract: A process for the preparation of highly purified optical isomers of desflurane, i.e. 2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane, is described wherein the highly purified opposite optical isomer of iso-flurane is reacted with bromine trifluoride in the cold, preferably in the presence of a solvent. A preferred solvent is bromine. The highly purified positive isomer of desflurane is advantageous over the negative isomer or the racemate.

Abstract: The present invention is directed to a method of preparing a compound 2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane by reacting 2-(difluoromethoxy)-1,1,1-trifluoro-2-chloroethane with bromine trifluoride. This reaction product is useful for inducing and maintaining anesthesia in warm blooded animals.

Abstract: The present invention is directed to a method for replacing a carboxylic acid group with a fluorine group in a halogenated aliphatic carboxylic acid compound having the formula, R-COOH, to prepare a fluorinated product having the formula, R-F, wherein R is a halogenated aliphatic group including straight- and branched-chain aliphatic groups selected from the group consisting of halogenated aliphatic and alkoxy-substituted halogenated aliphatic groups, wherein the method comprises the steps of (a) reacting the halogenated aliphatic carboxylic acid compound with bromine trifluoride, and (b) recovering the fluorinated product.

Abstract: A process for the preparation of a compound having the formula CF.sub.3 CHFOCH.sub.3 comprising reacting a fluorinating agent with the reaction product of CF.sub.3 CH(OH)OCH.sub.3 and p-toluene sulfonyl chloride and an improved method for the preparation of CHF.sub.2 OCHFCF.sub.3 through the use of such compounds.

Abstract: Process for preparing CHF.sub.2 OCHFCF.sub.3 through the use of novel intermediate compounds CHCl.sub.2 OCH.sub.2 COCl and CHCl.sub.2 OCHClCOCl.

Abstract: Sodium or potassium fluoride has been found to efficiently fluorinate the chloro atom adjacent the ether oxygen in chloro-fluoro organic ethers. The reaction proceeds efficiently without added solvent at an elevated temperature and pressure.

Abstract: Process for preparing CHF.sub.2 OCHFCF.sub.3 through the use of novel intermediate compounds CHCl.sub.2 OCH.sub.2 COCl and CHCl.sub.2 OCHClCOCl.

Abstract: A system for indicating the integrity of a normally sealed package utilizes a sensor containing a pH sensitive dye which displays a first color in equilibrium with normal atmospheric conditions and a second color when in equilibrium with an artificial atmosphere comprising an acidic gaseous material. When the air normally in the package is displaced by the artificial atmosphere, the pH sensitive dye assumes its second color. Loss of integrity of the sealed package results in loss of the acidic gaseous material. As a consequence, the pH sensitive dye reverts to its first color, thereby signaling the loss of package integrity.

Abstract: The present invention is directed to a method for replacing a carboxylic acid group with a fluorine .[.group.]. in a halogenated aliphatic carboxylic acid compound having the formula, R-COOH, to prepare a fluorinated product having the formula, R-F, wherein R is a halogenated aliphatic group including straight- and branched-chain aliphatic groups selected from the group consisting of halogenated aliphatic and .Iadd.halogenated .Iaddend.alkoxy-substituted .[.halogenated.]. aliphatic groups, wherein the method comprises the step of (a) reacting the halogenated aliphatic carboxylic acid compound with bromine trifluoride, and (b) recovering the fluorinated product.