Patents by Inventor Donald F. Reinhold

Donald F. Reinhold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for L-dopa
    Patent number: 4716246
    Abstract: A process for the preparation of (S)- or L-3-(3,4-dihydroxyphenyl)alanine (L-dopa) is described. The process utilizes water as reaction process solvent and proceeds via formation of an intermediate which can be kinetically resolved in a polar solvent to a precursor of the desired isomer and in which the undesired isomer can be efficiently racemized for reuse.
    Type: Grant
    Filed: August 22, 1986
    Date of Patent: December 29, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Donald F. Reinhold, Torleif Utne, Newton L. Abramson
  • Preparation of 4-aza-17-substituted-5.alpha.-androstan-3-ones useful as 5.alpha.-reductase inhibitors
    Patent number: 4220775
    Abstract: A method of preparing a compound of the formula: ##STR1## where Formula (I) may also have the structure of partial Formula (III); wherein, ##STR2## R' is hydrogen or methyl; R" is hydrogen or .beta.-methyl;R'" is .beta.-methyl or hydroxy;Z is (1) oxo;(2) .beta.-hydrogen and .alpha.-hydroxy; or .alpha.-hydrogen or .alpha.-hydroxyl and(3) (Y).sub.n Q where n=0 or 1, Y is a straight or branched hydrocarbon chain of 1 to 12 carbon atoms andQ is ##STR3## where R.sup.8 is, ##STR4## where the dashed bond replaces the 17.alpha. hydrogen; (6) cyano; or(7) tetrazolyl;and pharmaceutically acceptable salts of the above compounds;CHARACTERIZED IN THAT(I.) a compound of the formula: ##STR5## , where A has the meanings above except --CH.dbd.CH--, is (1) treated with an oxidizing agent at reduced temperatures to form the corresponding 5-oxo-3,5-seco-androstan-3-oic acid compound;(2) treating the product of step (1) with an amine of formula: R.sup.1 NH.sub.
    Type: Grant
    Filed: March 15, 1979
    Date of Patent: September 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Gary H. Rasmusson, David B. R. Johnston, Donald F. Reinhold, Torleif Utne, Ronald B. Jobson
  • Pyroglutamic acid salts of t-butylamino-2,3-dihydroxypropane
    Patent number: 4097490
    Abstract: Process for resolving enantiomers of 1-t-butylamino-2,3-dihydroxypropane using a pyroglutamic acid or a tartaric acid as resolving agent. The enantiomers of 1-t-butylamino-2,3-dihydroxypropane are useful in preparing .beta.-adrenergic blocking agents.
    Type: Grant
    Filed: February 9, 1977
    Date of Patent: June 27, 1978
    Assignee: Merck & Co., Inc.
    Inventor: Donald F. Reinhold
  • Preparation of 4,6-diamino-5-arylazopyrimidines and adenine compounds
    Patent number: 4092314
    Abstract: The present invention relates to a novel and useful process for preparing 4,6-diamino-5-arylazopyrimidine from an arylazomalononitrile in the presence of ammonium chloride and formamide. If desired, the 4,6-diamino-5-arylazopyrimidine may then be hydrogenated to form 4,5,6-triaminopyrimidine which, when the hydrogenation is carried out in the presence of formic acid or its derivative, gives adenine.
    Type: Grant
    Filed: October 18, 1976
    Date of Patent: May 30, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Michael C. Vander Zwan, Donald F. Reinhold
  • Process for preparing 3-fluoro-D-alanine and its deutero analogs
    Patent number: 3976689
    Abstract: 3-Fluoro-D-alanine and its deutero analogs, which are potent antibacterial agents, are prepared from fluoropyruvic acid by asymmetric synthesis using an optically active amine such as D-.alpha.-methyl-benzylamine.
    Type: Grant
    Filed: November 20, 1974
    Date of Patent: August 24, 1976
    Assignee: Merck & Co., Inc.
    Inventor: Donald F. Reinhold
  • Processes for asymmetric conversion of 3-fluoro-L-alanine and 2-deutero-3-fluoro-L-alanine to their D-isomers
    Patent number: 3950411
    Abstract: 3-Fluoro-L-alanine is transformed by asymmetric conversion, via an intermediate L-2-(halo)-3-fluoropropionic acid, to 3-fluoro-D-alanine. The 3-fluoro-D-alanine thus obtained is a potent antibacterial agent.
    Type: Grant
    Filed: February 24, 1975
    Date of Patent: April 13, 1976
    Assignee: Merck & Co., Inc.
    Inventor: Donald F. Reinhold