Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain triazolo compounds (referred to herein as TAZ compounds), and especially certain [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds, which, inter alia, inhibit AXL receptor tyrosine kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit AXL receptor tyrosine kinase function, and in the treatment of diseases and conditions that are mediated by AXL receptor tyrosine kinase, that are ameliorated by the inhibition of AXL receptor tyrosine kinase function, etc., including proliferative conditions such as cancer, etc.

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain triazolo compounds (referred to herein as TAZ compounds), and especially certain [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds, which, inter alia, inhibit AXL receptor tyrosine kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit AXL receptor tyrosine kinase function, and in the treatment of diseases and conditions that are mediated by AXL receptor tyrosine kinase, that are ameliorated by the inhibition of AXL receptor tyrosine kinase function, etc., including proliferative conditions such as cancer, etc.

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain triazolo compounds (referred to herein as TAZ compounds), and especially certain [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds, which, inter alia, inhibit AXL receptor tyrosine kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit AXL receptor tyrosine kinase function, and in the treatment of diseases and conditions that are mediated by AXL receptor tyrosine kinase, that are ameliorated by the inhibition of AXL receptor tyrosine kinase function, etc., including proliferative conditions such as cancer, etc.

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain triazolo compounds (referred to herein as TAZ compounds), and especially certain [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds, which, inter alia, inhibit AXL receptor tyrosine kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit AXL receptor tyrosine kinase function, and in the treatment of diseases and conditions that are mediated by AXL receptor tyrosine kinase, that are ameliorated by the inhibition of AXL receptor tyrosine kinase function, etc., including proliferative conditions such as cancer, etc.

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain triazolo compounds (referred to herein as TAZ compounds), and especially certain [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds, which, inter alia, inhibit AXL receptor tyrosine kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit AXL receptor tyrosine kinase function, and in the treatment of diseases and conditions that are mediated by AXL receptor tyrosine kinase, that are ameliorated by the inhibition of AXL receptor tyrosine kinase function, etc., including proliferative conditions such as cancer, etc.

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain triazolo compounds (referred to herein as TAZ compounds), and especially certain [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds, which, inter alia, inhibit AXL receptor tyrosine kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit AXL receptor tyrosine kinase function, and in the treatment of diseases and conditions that are mediated by AXL receptor tyrosine kinase, that are ameliorated by the inhibition of AXL receptor tyrosine kinase function, etc., including proliferative conditions such as cancer, etc.

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain triazolo compounds (referred to herein as TAZ compounds), and especially certain [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds, which, inter alia, inhibit AXL receptor tyrosine kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit AXL receptor tyrosine kinase function, and in the treatment of diseases and conditions that are mediated by AXL receptor tyrosine kinase, that are ameliorated by the inhibition of AXL receptor tyrosine kinase function, etc., including proliferative conditions such as cancer, etc.

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain triazolo compounds (referred to herein as TAZ compounds), and especially certain [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds, which, inter alia, inhibit AXL receptor tyrosine kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit AXL receptor tyrosine kinase function, and in the treatment of diseases and conditions that are mediated by AXL receptor tyrosine kinase, that are ameliorated by the inhibition of AXL receptor tyrosine kinase function, etc., including proliferative conditions such as cancer, etc.

Abstract: A multiple-choke unit for transporting and metering particulate material under ambient conditions wherein the material is compacted to bridging and then disturbed as it is friction driven through a duct. The duct has two opposed walls moving between the inlet and outlet which have a surface area that is larger than the surface area of a stationary wall or walls which form the other part of the duct. The duct includes a plurality of chokes which bridge by compaction and disturb the material as it is friction-driven through the unit. The unit provides simultaneous transport and metering of particulate material. The unit is used to transport particulate material under atmospheric conditions.

Abstract: A multiple-choke unit for transporting and metering particulate material wherein the material is compacted to bridging, disturbed and then recompacted as it is friction driven through a duct. The duct has two opposed walls moving between the inlet and outlet which have a surface area that is larger than the surface area of a stationary wall or walls which from the other part of the duct. The duct includes a plurality of chokes which bridge by compaction, disturb and recompact the material as it is friction-driven through the unit. The unit provides simultaneous transport and metering of particulate material. The unit may be used to transport particulate material under atmospheric conditions or into a pressurized system.

Abstract: A solid material pump or conveyance apparatus and method including a pump housing an inlet and an outlet with a passageway between them. The passageway is formed and defined by a friction drive wall which is movable relative the pump housing towards the outlet and a wall stationary relative the pump housing. The friction drive wall has a greater surface area for contacting the solid material than the stationary wall. The friction drive wall exerts frictional forces upon the solids material introduced through the housing inlet which exceed the frictional drag exerted upon the material by the stationary wall, so that the net frictional force drives the material in a forward direction toward the housing outlet. The solid material is compacted or compressed prior to or upon entry into the pumping apparatus to a sufficient level so that the solid material exhibits some of the properties of a liquid.

Abstract: An improved rotating retort seal having integral bearings for aligning the retort seals relative the sealing surface on the rotating vessel portion of the retort. The sealing function and bearing or seal alignment function are separated to extend seal life and improve sealing. Radial alignment bearings and axial alignment bearings are provided for continually positioning the seal assembly housing during sealing surface nutation. The sealing elements, which are fixed relative to the alignment bearings, is thereby continually aligned and realigned in response to sealing surface nutations during retort rotation. The alignment bearings are extended radially outward from the seals on the sealing surface to prevent damage of the bearings by materials processed in the retort. A lubrication passageway is placed between the alignment bearings and seals to provide for common lubrication of both alignment bearings and seals.

Abstract: A hydrostatic retort seal for sealing to a seal disc on the rotating vessel portion of a rotating retort. An annular caliper assembly is mounted concentrically around the seal disc. The annular caliper assembly includes a body portion having two arms. Each arm on its interior surface includes an annular sealing channel which is filled with liquid under pressure to provide a liquid interface seal layer between the caliper assembly arms and the seal disc. The sealing channels are movable laterally relative each other and are biased inward so that the distance between the two channels or seal layers may be adjusted continually to accommodate nutations and other variations of the rotating seal disc. The caliper assembly is mounted to the stationary retort portions by way of gimbals to allow universal movement of the caliper as it responds to sealing disc nutations. To complete the retort seal, a flexible seal boot is provided between the caliper assembly and stationary retort portion.

Abstract: This invention provides a system which includes winding apparatus for haug in and paying out a substantially inextensible steel rope tethering a floating vessel to a moorage or towing vessel, and a control system responsive to signals indicative of the tension in the steel rope and of the length of rope paid out for controlling the winding apparatus. There is also provided an energy reservoir for receiving and storing energy from the winding apparatus when the rope is paid out. The control system operates such that the tension in the steel rope does not exceed a predetermined value.

Abstract: A crane with a crane rope; means for attaching a load to the crane rope; a crane winch having a drum on which the crane rope can be wound; a crane motor which can drive the crane winch for hauling in or letting out the crane rope; a measuring winch having a drum with a measuring line windable thereon of length sufficient to reach at least as far as the crane rope can reach; a measuring winch motor which can turn the measuring winch drum to wind in or out the measuring line; means for attaching the outer extremity of the measuring line, away from the drum, to the load to be lifted by the crane; first transducer means operated by the measuring winch to provide a displacement signal proportional to any change, in relation to a predetermined value, and having regard to sign, of the length of measuring line extending from the measuring winch drum to the load; and crane motor control means operable by the displacement signal to control the crane motor to haul in or let out the crane rope substantially in synchronis

Abstract: A hydrostatic piston-and-cylinder machine includes an array of cylinders and a piston movable in each cylinder, a sinuous cam track and a cam-follower associated with the pistons engaging the cam track in a manner such that the pistons move to and fro along the axes of their cylinders on movement of the cylinder array along the cam track. For the relief of stresses due to high mutual convexity of the cam and cam follower the cam is shaped to give a relatively low velocity change rate for the pistons along the cylinder bores when the cam follower is negotiating the crests of the cam and a relatively high velocity change rate when the cam follower is negotiating the troughs of the cam.

Abstract: A fluid operated reciprocatable device has an outer, usually fixed, member nd an inner relatively movable member joined by a resilient member e.g., of rubber. The outer member is closed at one end so as to form an enclosure into which fluid under pressure can be admitted so as to displace the inner member in a given axial direction relative to the outer member. When a pulsating pressure is applied to the fluid the inner member vibrates axially in accordance with the pulses. The resilient member is proportioned so that its dimension in the axial direction is large in comparison with the thickness between the outer and inner members, e.g. 4 times larger. The properties of the resilient member are chosen so that it acts not only as a seal between the outer and inner members to contain fluid, but as a return spring whereby the inner member is returned, between fluid pulses, from an axially displaced position.