Patents by Inventor Donald H. Yamashiro

Donald H. Yamashiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Delayed treatment method of reducing ischemia-related neuronal damage
    Patent number: 5559095
    Abstract: A method and compositions for reducing neuronal damage related to an ischemic condition in a mammalian subject are described. The method includes administration of a voltage-gated calcium channel-blocking compound to the subject, 4-24 hours after the onset of the ischemic condition. Such a calcium channel blocking compound is effective to block norepinephrine release in mammalian CNS neuronal cells and is characterized by specific, high affinity binding to omega-conotoxin MVIIA binding sites. Also disclosed are novel peptide structures useful in the treatment method of the invention.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: September 24, 1996
    Assignee: Neurex Corporation
    Inventors: George P. Miljanich, Stephen S. Bowersox, James A. Fox, Karen L. Valentino, Robert S. Bitner, Donald H. Yamashiro
  • Screening method for neuroprotective compounds
    Patent number: 5424218
    Abstract: A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: June 13, 1995
    Assignee: Neurex Corporation
    Inventors: George P. Miljanich, Robert S. Bitner, Stephen S. Bowersox, James A. Fox, Karen L. Valentino, Donald H. Yamashiro
  • Screening method for neuroprotective compounds
    Patent number: 5264371
    Abstract: A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.
    Type: Grant
    Filed: March 23, 1992
    Date of Patent: November 23, 1993
    Assignee: Neurex Corporation
    Inventors: George P. Miljanich, Robert S. Bitner, Stephen S. Bowersox, James A. Fox, Karen L. Valentino, Donald H. Yamashiro, Makoto Tsubokawa
  • Method of reducing neuronal damage using omega conotoxin peptides
    Patent number: 5189020
    Abstract: A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.
    Type: Grant
    Filed: August 2, 1990
    Date of Patent: February 23, 1993
    Assignee: Neurex Corporation
    Inventors: George P. Miljanich, Robert S. Bitner, Stephen S. Bowersox, James A. Fox, Karen L. Valentino, Donald H. Yamashiro, Makoto Tsubokawa
  • Method of treating ischemia-related neuronal damage
    Patent number: 5051403
    Abstract: A method of reducing neuronal damage related to an ischemic condition in a human patient, such as stroke-induced damage, by administration of a binding/inhibitory omega-conotoxin peptide.
    Type: Grant
    Filed: November 22, 1989
    Date of Patent: September 24, 1991
    Assignee: Neurex Corporation
    Inventors: George P. Miljanich, Robert S. Bitner, Stephen S. Bowersox, James A. Fox, Karen L. Valentino, Donald H. Yamashiro
  • Biologically active analogs of ACTH and radioimmuno assay therefor
    Patent number: 4415546
    Abstract: A fully steroidogenically active analog of ACTH is disclosed. The analog differs from natural ACTH in that phenylalanine replaces tyrosine in the second position on the peptide chain; and norleucine replaces methionine in the fourth position on the peptide chain. The analog may be iodinated to yield [I]Tyr.sup.2 -Phe.sup.2,Nle.sup.4 -ACTH, which also retains full steroidogenic activity. When labeled with iodine-125 the analog is useful in following steroidogenic processes and also in radioimmunoassays for ACTH.
    Type: Grant
    Filed: May 12, 1981
    Date of Patent: November 15, 1983
    Inventors: Janakiraman Ramachandran, Douglas I. Buckley, Donald H. Yamashiro, James R. Hagman