Patents by Inventor Donald Hilvert

Donald Hilvert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11951194
    Abstract: Described are effervescent dissolvable solid structures comprising effervescent agglomerated particles which enhance the consumer experience and can improve dissolution of the structure. Also described are processes for the Dissolvable Solid Structure comprising effervescent agglomerated particles. Also described are methods for making the effervescent agglomerated particle.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: April 9, 2024
    Inventors: Stephen Robert Glassmeyer, Jennifer Elaine Hilvert, Jason Donald McCarty, Eric Paul Granberg, Andreas Josef Dreher, Michael Sean Pratt, Mark William Hamersky
  • Publication number: 20230080270
    Abstract: The invention relates to a lipoprotein cage for intracellular delivery of cargo, said lipoprotein cage comprises (i) a protein cage comprising at least one polypeptide comprising an amino acid sequence I consisting of SEQ ID NO: 1, wherein said protein cage possesses a positively charged interior; and (ii) a surfactant composition comprising one or more amphiphiles, wherein the one or more amphiphiles are selected such that the net charge of the composition is negative, wherein said surfactant composition is encapsulated into the assembled protein cage.
    Type: Application
    Filed: February 14, 2021
    Publication date: March 16, 2023
    Inventors: Donald HILVERT, Thomas EDWARDSON
  • Patent number: 11326196
    Abstract: Disclosed is a system and method for production of DNA particles and use thereof. The DNA particles can be produced by amplification of nucleic acid molecule(s). Alternatively, DNA particles can be prepared by condensing multiple DNA molecules. The DNA condensation into a particle is mainly triggered by pyrophosphate and positively charged cations (e.g. magnesium). DNA particles can be applied for numerous biological applications but not limited to directed evolution, proteomics, drug delivery and imaging. DNA particles can be used to synthesize proteins using in vitro transcription/translation reaction.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: May 10, 2022
    Assignees: VILNIUS UNIVERSITY, ETH 7LIRICH
    Inventors: Linas Mazutis, Greta Stonyte, Vaidotas Kiseliovas, Rapolas Zilionis, Arvydas Janulaitis, Robertas Galinis, Sabine Studer, Donald Hilvert
  • Publication number: 20210163540
    Abstract: The present invention relates to polypeptides self-assembling into nanoparticles. In particular, the invention relates to a polypeptide comprising an amino acid sequence I (SEQ ID NO: 1), a nucleic acid sequence encoding said polypeptide, a nanoparticle comprising at least one polypeptide of the invention, a complex comprising said nanoparticle and one or more cargo molecules, and a method for transfecting a cell with said complex.
    Type: Application
    Filed: August 6, 2019
    Publication date: June 3, 2021
    Inventors: Thomas George Watt EDWARDSON, Donald HILVERT
  • Publication number: 20190002943
    Abstract: Disclosed is a system and method for production of DNA particles and use thereof. The DNA particles can be produced by amplification of nucleic acid molecule(s). Alternatively, DNA particles can be prepared by condensing multiple DNA molecules. The DNA condensation into a particle is mainly triggered by pyrophosphate and positively charged cations (e.g. magnesium). DNA particles can be applied for numerous biological applications but not limited to directed evolution, proteomics, drug delivery and imaging. DNA particles can be used to synthesize proteins using in vitro transcription/translation reaction.
    Type: Application
    Filed: January 10, 2017
    Publication date: January 3, 2019
    Inventors: Linas MAZUTIS, Greta STONYTE, Vaidotas KISELIOVAS, Rapolas ZILIONIS, Arvydas JANULAITIS, Robertas GALINIS, Sabine STUDER, Donald HILVERT
  • Patent number: 5208152
    Abstract: Molecules that catalyze the reaction of a cyclic conjugated diene having a fugitive leaving group in a five- or six-membered ring containing the conjugated double bonds and a dienophile that contains a reactive multiple bond to form a reaction product that contains a five- or six-membered ring and at least two endocyclic double bonds from a Diels-Alder [4+2] cycloaddition/fragmentation reaction that is followed by a reverse Diels-Alder reaction are disclosed. The catalyst molecules contain an antibody combining site that immunoreacts with an antigen whose structure (i) includes a [2.2.1] or [2.2.2] bicyclic ring system that is absent from the reaction product and (ii) contains at least one endocyclic double bond fewer than the number of endocyclic double bonds present in the reaction product. Methods of preparing and using the catalyst molecules are also disclosed.
    Type: Grant
    Filed: February 27, 1992
    Date of Patent: May 4, 1993
    Assignee: The Scripps Research Institute
    Inventors: Donald Hilvert, Kenneth W. Hill