Patents by Inventor Donald J. Thomas
Donald J. Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 12128414Abstract: An automated method for performing an assay of the present disclosure can be performed in a microfluidic device that is a lateral flow device having numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. Each chamber can have a reagent recess proximal to an inlet end of the chamber. A reagent pellet formed in a reagent recess can be effectively mixed with a sample as the sample flows into the chamber. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with, for example, a chamber for performing an amplification reaction.Type: GrantFiled: September 2, 2022Date of Patent: October 29, 2024Assignee: MESA BIOTECH LLCInventors: Mark Nowakowski, Michael Wang, Robert B Cary, Hong Cai, Conrad Lindberg, Martin Bouliane, Donald J Thomas
-
Patent number: 12023672Abstract: A lateral flow assay device of the present disclosure has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The device also can have a gasket to ensure free air movement between open vent pockets. Flow control features that protrude horizontally into a chamber proximal to an outlet act to deflect the flow to the side of the chamber opposite from the outlet, prior to the flow entering the outlet. Such features can reduce the flow velocity of the sample fluid and increase the effective fluid flow path length, enhance mixing of reagents with a sample, and enabling more accurate control of fluid flow in the device.Type: GrantFiled: September 2, 2022Date of Patent: July 2, 2024Assignee: Mesa Biotech, Inc.Inventors: Mark Nowakowski, Michael Wang, Robert B Cary, Hong Cai, Conrad Lindberg, Martin Bouliane, Donald J Thomas
-
Publication number: 20240076724Abstract: An automated method for performing an assay of the present disclosure can be performed in a microfluidic device that is a lateral flow device having numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. Each chamber can have a reagent recess proximal to an inlet end of the chamber. A reagent pellet formed in a reagent recess can be effectively mixed with a sample as the sample flows into the chamber. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with, for example, a chamber for performing an amplification reaction.Type: ApplicationFiled: September 2, 2022Publication date: March 7, 2024Inventors: Mark Nowakowski, Michael Wang, Robert B Cary, Hong Cai, Conrad Lindberg, Martin Bouliane, Donald J Thomas
-
Publication number: 20240075473Abstract: A lateral flow assay device of the present disclosure has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The device also can have a gasket to ensure free air movement between open vent pockets. Flow control features that protrude horizontally into a chamber proximal to an outlet act to deflect the flow to the side of the chamber opposite from the outlet, prior to the flow entering the outlet. Such features can reduce the flow velocity of the sample fluid and increase the effective fluid flow path length, enhance mixing of reagents with a sample, and enabling more accurate control of fluid flow in the device.Type: ApplicationFiled: September 2, 2022Publication date: March 7, 2024Inventors: Mark Nowakowski, Michael Wang, Robert B Cary, Hong Cai, Conrad Lindberg, Martin Bouliane, Donald J Thomas
-
Publication number: 20240033733Abstract: A disposable cassette for detecting nucleic acids or performing other assays. The cassette can be inserted into a base station during use. The cassette has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The cassette also can have a gasket to ensure free air movement between open vent pockets. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with the vent pockets and the chambers. Recesses in the cassette channels or chambers can have structures such as ridges or grooves to direct fluid flow to enhance rehydration of lyophilized reagents disposed in the recess.Type: ApplicationFiled: June 21, 2023Publication date: February 1, 2024Inventors: Donald J. Thomas, Hong Cai, Robert B Cary
-
Publication number: 20180304260Abstract: A disposable cassette for detecting nucleic acids or performing other assays. The cassette can be inserted into a base station during use. The cassette has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The cassette also can have a gasket to ensure free air movement between open vent pockets. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with the vent pockets and the chambers. Recesses in the cassette channels or chambers can have structures such as ridges or grooves to direct fluid flow to enhance rehydration of lyophilized reagents disposed in the recess.Type: ApplicationFiled: April 20, 2018Publication date: October 25, 2018Applicant: Mesa Biotech, Inc.Inventors: Donald J. Thomas, Hong Cai, Robert B. Cary
-
Publication number: 20160310948Abstract: A disposable cassette for detecting nucleic acids or performing other assays. The cassette can be inserted into a base station during use. The cassette has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The cassette also can have a gasket to ensure free air movement between open vent pockets. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with the vent pockets and the chambers.Type: ApplicationFiled: April 25, 2016Publication date: October 27, 2016Inventors: Mark Nowakowski, Michael Wang, Robert B. Cary, Hong Cai, Conrad Lindberg, Martin Bouliane, Donald J. Thomas
-
Publication number: 20140151300Abstract: Processes and systems for treating high salinity aqueous liquids containing dissolved minerals, suspended solids, colloidal solids, free oil and grease, dissolved organics, and dissolved hydrocarbons. The liquid is passed into an electrocoagulation system in fluid communication with a solids removal clarifier, pressurized ultrafiltration system, the draw side of forward osmosis, and a dilute draw water reverse osmosis system. Impaired water with high sulfate content is used as a source of deionized water for dilution of the forward osmosis draw solution. After concentration, the forward osmosis feed solution is further treated by lime soda softening and sludge from the softening system may be recycled to increase hardness precipitation and silica removal, the outfall from which may be treated by a separate ultrafiltration system and a feed water reverse osmosis system. Concentrate from the feed water reverse osmosis system can be treated to offer a zero liquid or near zero liquid discharge.Type: ApplicationFiled: December 5, 2012Publication date: June 5, 2014Applicant: WATER & POWER TECHNOLOGIES, INC.Inventors: Jeffrey D. Savage, Joseph C. Jimerson, Donald J. Thomas
-
Patent number: 7718069Abstract: The invention relates to a method and system for treating an aqueous liquid containing dissolved minerals and dissolved hydrocarbons. Method steps and apparatus for treating a waste water feed stream are disclosed which utilize a warm lime softening system in fluid communication with the waste water feed stream, wherein sludge from the warm lime softening system is recycled to improve lime utilization and enhance silica and boron removal without the addition of an external source of magnesium. In addition, a microfiltration system and/or an air stripper system may be used in fluid communication with at least one reverse osmosis system to produce a treatment water that meets state and federal guidelines for surface discharge.Type: GrantFiled: March 17, 2009Date of Patent: May 18, 2010Assignee: Water & Power Technologies, Inc.Inventors: James W. Laraway, Richard E. Weber, Donald J. Thomas
-
Publication number: 20090173692Abstract: The invention relates to a method and system for treating an aqueous liquid containing dissolved minerals and dissolved hydrocarbons. Method steps and apparatus for treating a waste water feed stream are disclosed which utilize a warm lime softening system in fluid communication with the waste water feed stream, wherein sludge from the warm lime softening system is recycled to improve lime utilization and enhance silica and boron removal without the addition of an external source of magnesium. In addition, a microfiltration system and/or an air stripper system may be used in fluid communication with at least one reverse osmosis system to produce a treatment water that meets state and federal guidelines for surface discharge.Type: ApplicationFiled: March 17, 2009Publication date: July 9, 2009Applicant: WATER & POWER TECHNOLOGIES, INC.Inventors: James W. Laraway, Richard E. Weber, Donald J. Thomas
-
Patent number: 7520993Abstract: The invention relates to a method and system for treating an aqueous liquid containing dissolved minerals and dissolved hydrocarbons. Method steps and apparatus for treating a waste water feed stream are disclosed which utilize a warm lime softening system in fluid communication with the waste water feed stream, wherein sludge from the warm lime softening system is recycled to improve lime utilization and enhance silica and boron removal without the addition of an external source of magnesium. In addition, a microfiltration system and/or an air stripper system may be used in fluid communication with at least one reverse osmosis system to produce a treatment water that meets state and federal guidelines for surface discharge.Type: GrantFiled: December 6, 2007Date of Patent: April 21, 2009Assignee: Water & Power Technologies, Inc.Inventors: James W. Laraway, Richard E. Weber, Donald J. Thomas
-
Publication number: 20040135279Abstract: A method of manufacturing a plastic encapsulated plastic structural member includes the steps of forming a mold having first and second mold parts which form an enclosed mold defining a cavity therein having a configuration the same as the configuration of this structural member to be formed. A core of wooden material having holes on each of two opposed surfaces is formed and positioned in the cavity so that pins on the mold parts engage the holes. A foamable plastic material and nitrogen is injected under low pressure into the cavity to cause the plastic material to foam up and fill the space between the core and the cavity all around the core. The plastic material is then allowed to harden to form a plastic layer around the core. The mold parts are then removed. The holes may be closed with the plug of additional plastic material.Type: ApplicationFiled: December 12, 2003Publication date: July 15, 2004Inventors: Anthony P. Habodasz, Michael D. Johnson, Donald J. Thomas
-
Patent number: 6428266Abstract: A robot with a base, a first link connected to the base by a shoulder joint, and a second link connected to the first link by an elbow joint. A shoulder motor drives the shoulder joint, and an elbow motor drives the elbow joint. An upper elbow pulley is coupled to the first link. An end effector pulley coupled to the upper elbow pulley, and a dual-bladed end effector driven by the end effector pulley. The diameter of the upper elbow pulley and the diameter of the end effector pulley are related by a 1:2 ratio. Ferro-fluid seals are used to seal each joint. A static seal joins the seams of the links. Each arm link has a particle filter. The robot can communicate electrical signals through the revolute joints with a conductive slip-ring assembly. Alternately, the joint may have an inner cylinder and an outer cylinder, and a cable may be coiled between the cylinders.Type: GrantFiled: July 9, 1996Date of Patent: August 6, 2002Assignee: Brooks Automation, Inc.Inventors: Todd R. Solomon, Donald J. Thomas, Gerard J. Labonville
-
Publication number: 20020020305Abstract: A grill or kitchen unit for outdoor use, and includes a cooking unit which is translatable between a position over a heat source and a position laterally adjacent to the heat source, for cooling and/or further preparation of foods being cooked within the unit.Type: ApplicationFiled: September 10, 2001Publication date: February 21, 2002Inventors: Vance M. Patterson, Mary J. Patterson, Donald J. Thomas
-
Patent number: 6343545Abstract: A grill or kitchen unit for outdoor use, and includes a cooking unit which is translatable between a position over a heat source and a position laterally adjacent to the heat source, for cooling and/or further preparation of foods being cooked within the unit.Type: GrantFiled: October 25, 1999Date of Patent: February 5, 2002Inventors: Vance M. Patterson, Mary J. Patterson, Donald J. Thomas
-
Patent number: 5970855Abstract: A portable grill or portable kitchen unit for outdoor use, and includes a cooking unit which is translatable between a position over a heat source and a position laterally adjacent to the heat source, for cooling and/or further preparation of foods being cooked within the unit.Type: GrantFiled: March 19, 1998Date of Patent: October 26, 1999Inventors: Vance M. Patterson, Mary J. Patterson, Donald J. Thomas
-
Patent number: 5794487Abstract: A robot with a base, a first link connected to the base by a shoulder joint, and a second link connected to the first link by an elbow joint. A shoulder motor drives the shoulder joint, and an elbow motor drives the elbow joint. An upper elbow pulley is coupled to the first link. An end effector pulley coupled to the upper elbow pulley, and a dual-bladed end effector driven by the end effector pulley. The diameter of the upper elbow pulley and the diameter of the end effector pulley are related by a 1:2 ratio. Ferro-fluid seals are used to seal each joint. A static seal joins the seams of the links. Each arm link has a particle filter. The robot can communicate electrical signals through the revolute joints with a conductive slip-ring assembly. Alternately, the joint may have an inner cylinder and an outer cylinder, and a cable may be coiled between the cylinders.Type: GrantFiled: October 23, 1995Date of Patent: August 18, 1998Assignee: Smart MachinesInventors: Todd R. Solomon, Donald J. Thomas, Gerard J. Labonville
-
Patent number: 5775169Abstract: A robotic arm has a base with a top surface and an aperture therein. A shaft extends up through the aperture, and there is a gap between the shaft and an inner edge of the aperture. A splash guard may extend over said gap, and an indentation in said top surface may at least partially surround the gap. A seal, including a bearing and a barrier, is located in the gap. The bearing allows the inner and outer surfaces to rotate relative to each other. The barrier includes a plurality of annular outward-pointing flanges attached to an inner surface interleaved with a plurality of annular inward-pointing flanges attached to an outer surface. The flanges may be angled and have an upturned lip located at an inner edge of each flange. The seal may include a magnet attached to a flange.Type: GrantFiled: July 9, 1996Date of Patent: July 7, 1998Assignee: Smart MachinesInventors: Todd Solomon, Donald J. Thomas
-
Patent number: 5676472Abstract: A rotary seal is located in a gap between an inner surface and an outer surface. A radial bearing allows the inner and outer surfaces to rotate relative to each other. A radial barrier includes a plurality of annular outward-pointing flanges attached to the inner surface interleaved with a plurality of annular inward-pointing flanges attached to the outer surface. The flanges may be angled and have an upturned lip located at an inner edge of each flange. The radial seal may include a magnet. A robotic arm has a first housing with a top surface and an aperture therein. A shaft extends up through the aperture, and there is a gap between the shaft and an inner edge of the aperture. A splash guard may extend over said gap, and an indentation in said top surface may at least partially surround the gap.Type: GrantFiled: July 10, 1995Date of Patent: October 14, 1997Assignee: Smart MachinesInventors: Todd Solomon, Donald J. Thomas
-
Patent number: 5493082Abstract: There is provided an elastomeric switching device for use with electrical circuits, such as those on a printed circuit board. The elastomeric switching device comprises an elastomeric pad constructed from a plurality of parallel strips of conductive material between layers of non-conductive or insulating material together with a moveable conductive contact which is aligned with the elastomeric pad. The elastomeric pad is predisposed in contact with the circuits on the printed circuit board. The moveable conductive contact establishes electrical connections between the affected circuits via the conductive strips of the elastomeric pad. The proper alignment and orientation of the elastomeric pad and moveable conductive contact relative to the circuits is maintained by the structural and mechanical features of a housing.Type: GrantFiled: August 9, 1994Date of Patent: February 20, 1996Assignee: Hughes Aircraft CompanyInventors: Kenneth A. Bloch, Donald J. Thomas, Steven E. Smart