Abstract: Compounds of Formula I, commonly referred to as bis-indole pyrroles, including isolated naturally-occurring compounds, synthetic and semi-synthetic derivatives thereof having antimicrobial properties and to antimicrobial compositions that include one or more of bis-indole pyrroles and their derivatives or analogs having antimicrobial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating bacterial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

Abstract: Compounds of Formula I, commonly referred to as bis-indole pyrroles, including isolated naturally-occurring compounds, synthetic and semi-synthetic derivatives thereof having antimicrobial properties and to antimicrobial compositions that include one or more of bis-indole pyrroles and their derivatives or analogs having antimicrobial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating bacterial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

Abstract: The present invention relates to oral compositions comprising a stannous ion source, a fluoride ion source, and a polymeric mineral surface active agent that binds stannous, said compositions providing adequate therapeutic efficacy with minimal side effects of tooth staining and astringency. The composition simultaneously provides reduction and control of supragingival calculus. The present oral care compositions may be formulated as single phase or dual phase compositions. The present invention also provides a method for effective delivery of stannous-containing compositions with minimal side effects of tooth staining or astringency and with effective tartar control by administering to a subject a stable dentifrice composition comprising a clinically effective amount of stannous fluoride and/or other stannous salts in combination with a fluoride ion source and a polymeric mineral surface active agent, preferably a phosphate- or phosphonate-containing polymer.

Abstract: The present invention relates to oral composition comprising a polymeric surface active agent wherein the oral composition provides surface conditioning effects on a subject's teeth and/or oral mucosa. The surface conditioning effects include (a) increased hydrophilic character of oral surfaces as measured by a decrease in water contact angles or an increase in anionic surface charge and surface charge density and (b) decreased pellicle film thickness. The present invention also relates to methods of providing surface conditioning effects to a subject's tooth and mucosal surfaces and methods of preventing and controlling tartar and tooth staining by administering to the subject an oral composition comprising a polymeric surface active agent.

Abstract: The present invention relates to oral composition comprising a polymeric surface active agent wherein the oral composition provides surface conditioning effects on a subject's teeth and/or oral mucosa. The surface conditioning effects include (a) increased hydrophilic character of oral surfaces as measured by a decrease in water contact angles or an increase in anionic surface charge and surface charge density and (b) decreased pellicle film thickness. The present invention also relates to methods of providing surface conditioning effects to a subject's tooth and mucosal surfaces and methods of preventing and controlling tartar and tooth staining by administering to the subject an oral composition comprising a polymeric surface active agent.

Abstract: Disclosed are methods of treating and protecting teeth against erosion by use of oral compositions comprising polymeric mineral surface active agents, metal ions such as stannous and zinc and combinations thereof. The present methods provide improved resistance of teeth to erosive demineralization or dissolution and prevention of tooth damage by subsequent exposure of teeth to erosive chemicals such as acidic foods and beverages.

Abstract: Disclosed are methods of treating and protecting teeth against erosion by use of oral compositions comprising polymeric mineral surface active agents, metal ions such as stannous and zinc and combinations thereof. The present methods provide improved resistance of teeth to erosive demineralization or dissolution and prevention of tooth damage by subsequent exposure of teeth to erosive chemicals such as acidic foods and beverages.

Abstract: The present invention relates to oral compositions comprising a stannous ion source, a fluoride ion source, and a polymeric mineral surface active agent that binds stannous, said compositions providing adequate therapeutic efficacy with minimal side effects of tooth staining and astringency. The composition simultaneously provides reduction and control of supragingival calculus. The present oral care compositions may be formulated as single phase or dual phase compositions. The present invention also provides a method for effective delivery of stannous-containing compositions with minimal side effects of tooth staining or astringency and with effective tartar control by administering to a subject a stable dentifrice composition comprising a clinically effective amount of stannous fluoride and/or other stannous salts in combination with a fluoride ion source and a polymeric mineral surface active agent, preferably a phosphate- or phosphonate-containing polymer.

Abstract: The present invention relates to oral compositions comprising a stannous ion source, a fluoride ion source, and a polymeric mineral surface active agent that binds stannous, said compositions providing adequate therapeutic efficacy with minimal side effects of tooth staining and astringency. The composition simultaneously provides reduction and control of supragingival calculus. The present oral care compositions may be formulated as single phase or dual phase compositions. The present invention also provides a method for effective delivery of stannous-containing compositions with minimal side effects of tooth staining or astringency and with effective tartar control by administering to a subject a stable dentifrice composition comprising a clinically effective amount of stannous fluoride and/or other stannous salts in combination with a fluoride ion source and a polymeric mineral surface active agent, preferably a phosphate- or phosphonate-containing polymer.

Abstract: An impact absorbing device, preferably for trucks, attenuates the impact of colliding vehicles. A rigid mount secures the apparatus to the truck rear underside. A rigid chassis is suspended from the mount. An impact absorbing bumper exposed for contact at the truck rear controls a displaceable ram that is slidably captivated by the chassis. A wound band assembly suspended beneath the chassis is activated by displacement of the ram. The wound band assembly connects to suitable levers on each side of the chassis that interconnect it with shock absorbers. Energy is dissipated in the shock absorbers over a predetermined compression deflection. This distance is substantially less than the travel distance of the ram, and the mechanical advantage reduction is provided by the combination of the levers and the wound band assembly. When the bumper is forcibly impacted, the ram accelerates longitudinally, tightening the wound band assembly and compressing the shock absorbers through the levers.

Abstract: Methods for manufacturing baking soda dentifrice compositions containing pyrophosphate tartar control agent using tetrasodium pyrophosphate. The process and compositions have less than about 20% of the pyrophosphate dissolved in the dentifrice composition.

Abstract: Oral compositions providing antitartar and antigingivitis benefits containing an antitartar agent and a stannous salt.

Abstract: A selectively lockable, articulated boat trailer comprising a carriage having a selectively pivoted front axle controlled by a jack column assembly. The carriage comprises a wheeled trailer and a separate front axle assembly adapted to be coupled to a conventional tow vehicle. The wheeled axle of the trailer is suspended perpendicular to the longitudinal axis of the trailer. A system for retrofitting to existing trailers includes independent framework that receives the tongue of the trailer fixed to the jack column assembly. Regardless of the configuration, retrofit or original equipment, the separate front axle assembly is operatively coupled to the trailer by the jack column assembly. The jack column assembly provides lifting action and a pivot between the trailer section and the separate front axle assembly. Sleeved portions of the jack column assembly coaxially rotate relative to one another.

Abstract: Disclosed are oral compositions which are effective against calculus comprising a tripolyphosphate salt and an orthophosphate salt.

Abstract: Disclosed are oral compositions which are effective against calculus comprising a tripolyphosphate salt and an orthophosphate salt.

Abstract: Visibility to the interior of a microwave oven is improved through a microwave shield that can be driven with periodic motion to increase the visibility through the shield, with such driving being accomplished by an electromechanical vibrator, a manual impulse given to the shield that is spring mounted, a power take-off from a conventional motor driven microwaver mixer, a separately motor driven cam, or the like. Such periodic motion may be oscillation such as reciprocation, or rotary with constant, decreasing or increasing amplitude, which amplitude may be the distance between adjacent apertures in the shield. Such periodic movement of the shield will scatter the microwave energy striking it and improve the distribution of microwave energy within the oven, which scattering may be enhanced by a three-dimensional mechanical texture given to the interior face of the shield, a coating with crystalline or metallic particles, or the like that will randomly scatter microwave energy striking it.