Patents by Inventor Donald K. Pirie

Donald K. Pirie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparation of azetidinone-1-oxoacetate by oxidation of the corresponding 2-hydroxyacetate
    Patent number: 4751297
    Abstract: A process for production of a 2-azetidinone-1-oxoacetate of the formula ##STR1## useful as an intermediate for preparation of 2-SR.sup.2 -substituted-2-penem-3-carboxylate andtibacterial agents;R is a conventional hydroxy protecting group, R.sup.1 is certain carboxy protecting groups and ##STR2## and m and n are each 0, 1 or 2; which comprises contacting a corresponding (2-oxo-1-axetidinyl)-N-2-hydroxyacetate ester of the formula ##STR3## with manganese dioxide.
    Type: Grant
    Filed: March 20, 1987
    Date of Patent: June 14, 1988
    Assignee: Pfizer Inc.
    Inventors: Berkeley W. Cue, Jr., Donald K. Pirie
  • Process for preparing penicillanic acid 1,1-dioxide derivatives
    Patent number: 4588527
    Abstract: 6-alpha/beta-[(C.sub.1 -C.sub.4)Alkoxyaminomethyl and benzyloxyaminomethyl]penicillanic acid 1,1-dioxides, pharmaceutically acceptable salts thereof and conventional esters thereof hydrolyzable under physiological conditions, all of which are useful in medicine as beta-lactamase inhibitors; intermediates and processes therefor; and a process for the conversion of the present compounds to 6-alpha- and 6-beta-(aminomethyl)penicillanic acid 1,1-dioxides and derivatives.
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: May 13, 1986
    Assignee: Pfizer Inc.
    Inventors: Donald K. Pirie, Robert A. Volkmann, Edward F. Kleinman
  • Beta-lactamase inhibiting 6-(alkoxyamino-methyl) penicillanic acid 1,1-dioxide and derivatives
    Patent number: 4499017
    Abstract: 6-alpha/beta-[(C.sub.1 -C.sub.4)Alkoxyaminomethyl and benzyloxyaminomethyl]penicillanic acid 1,1-dioxides, pharmaceutically acceptable salts thereof and conventional esters thereof hydrolyzable under physiological conditions, all of which are useful in medicine as beta-lactamase inhibitors; intermediates and processes therefor; and a process for the conversion of the present compounds to 6-alpha- and 6-beta-(aminomethyl)penicillanic acid 1,1-dioxides and derivatives.
    Type: Grant
    Filed: June 6, 1983
    Date of Patent: February 12, 1985
    Assignee: Pfizer Inc.
    Inventors: Donald K. Pirie, Robert A. Volkmann, Edward F. Kleinman
  • Process for debromination of dibromopenicillanic acid and derivatives
    Patent number: 4468351
    Abstract: A process for the debromination of 6-monobromo- and 6,6-dibromopenicillanic acid, and various derivatives thereof, by the action of a bisulfite salt. The debrominated compounds produced find various utilities, as beta-lactamase inhibitors useful in therapy in combination with known beta-lactam antibiotics, or as intermediates in the further synthesis of useful beta-lactam compounds.
    Type: Grant
    Filed: June 6, 1983
    Date of Patent: August 28, 1984
    Assignee: Pfizer Inc.
    Inventors: Donald K. Pirie, Paul D. Weeks
  • Antibacterial esters of resorcinol with ampicillin and penicillanic acid 1,1-dioxide derivatives
    Patent number: 4351840
    Abstract: Bis-esters of resorcinol (1,3-dihydroxybenzene) with ampicillin or amoxicillin and penicillanic acid 1,1-dioxide or 6-beta-(hydroxymethyl)penicillanic acid 1,1-dioxide, having utility as antibacterial agents; processes therefor; and intermediates therefor, including m-hydroxyphenyl esters of penicillanic acid, 6-beta-(hydroxymethyl)penicillanic acid, and azidocillin.
    Type: Grant
    Filed: September 18, 1981
    Date of Patent: September 28, 1982
    Assignee: Pfizer Inc.
    Inventor: Donald K. Pirie