Patents by Inventor Donald Kufe

Donald Kufe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PERSONALIZED FUSION CELL VACCINES
    Publication number: 20240024474
    Abstract: The present invention provides compositions and methods for treating cancer.
    Type: Application
    Filed: November 12, 2021
    Publication date: January 25, 2024
    Inventors: David Avigan, Jacalyn Rosenblatt, Donald Kufe
  • POLYMERIC NANOPARTICLES PROVIDING NUCLEIC ACIDS ENCODING TNF-a
    Publication number: 20230157969
    Abstract: The present invention relates to polymeric nanoparticles comprising a cytokine or a nucleic acid encoding for a cytokine, pharma-ceutical compositions comprising the same, and methods for treating certain diseases comprising administering these polymeric nanoparticles to a subject in need thereof.
    Type: Application
    Filed: October 6, 2022
    Publication date: May 25, 2023
    Inventors: Surender KHARBANDA, Vasundhara Shukla, Donald Kufe, Harpal Singh
  • Polymeric nanoparticles providing nucleic acids encoding TNF-?
    Patent number: 11484507
    Abstract: The present invention relates to polymeric nanoparticles comprising a cytokine or a nucleic acid encoding for a cytokine, pharmaceutical compositions comprising the same, and methods for treating certain diseases comprising administering these polymeric nanoparticles to a subject in need thereof.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: November 1, 2022
    Assignee: Hillstream BioPharma, Inc.
    Inventors: Surender Kharbanda, Vasundhara Shukla, Donald Kufe, Harpal Singh
  • Compositions and methods of treating cancer
    Patent number: 11026921
    Abstract: The present invention provides compositions and methods for treating cancer.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: June 8, 2021
    Assignees: Dana-Farber Cancer Institute, Inc., Beth Israel Deaconess Medical Center
    Inventors: David Avigan, Jacalyn Rosenblatt, Donald Kufe
  • COMPOSITIONS AND METHODS OF TREATING CANCER
    Publication number: 20200323952
    Abstract: The present invention provides compositions and methods for treating cancer.
    Type: Application
    Filed: November 21, 2016
    Publication date: October 15, 2020
    Inventors: David Avigan, Jacalyn Rosenblatt, Donald Kufe
  • COMPOSITIONS AND METHODS OF TREATING CANCER
    Publication number: 20200056174
    Abstract: The present invention provides methods of treating cancer by de-repressing the anti-tumor immune response.
    Type: Application
    Filed: September 8, 2017
    Publication date: February 20, 2020
    Inventor: Donald Kufe
  • COMPOSITIONS AND METHODS OF TREATING CANCER
    Publication number: 20200000896
    Abstract: The present invention provides compositions and methods for treating cancer, wherein the composition comprises: a. a population a cells comprising a dendritic cell/tumor cell fusion or a dendritic cell/extracellular vesicle fusion; and b. an indoleamine-2,3-dioxygenase (IDO) inhibitor and/or a hypomethylating agent (HMA).
    Type: Application
    Filed: November 14, 2017
    Publication date: January 2, 2020
    Inventors: David Avigan, Jacalyn Rosenblatt, Donald Kufe
  • PERSONALIZED VACCINES
    Publication number: 20190343939
    Abstract: The present invention provides compositions and methods for treating cancer.
    Type: Application
    Filed: January 11, 2018
    Publication date: November 14, 2019
    Inventor: Donald Kufe
  • POLYMERIC NANOPARTICLES
    Publication number: 20190321305
    Abstract: The present invention relates to polymeric nanoparticles comprising a cytokine or a nucleic acid encoding for a cytokine, pharmaceutical compositions comprising the same, and methods for treating certain diseases comprising administering these polymeric nanoparticles to a subject in need thereof.
    Type: Application
    Filed: November 1, 2017
    Publication date: October 24, 2019
    Inventors: SURENDER KHARBANDA, VASUNDHARA SHUKLA, DONALD KUFE, HARPAL SINGH
  • COMPOSITIONS AND METHODS OF TREATING CANCER
    Publication number: 20190269775
    Abstract: The present invention provides compositions and methods for treating cancer.
    Type: Application
    Filed: November 14, 2017
    Publication date: September 5, 2019
    Inventors: David Avigan, Jacalyn Rosenblatt, Donald Kufe
  • DENDRITIC CELL-EXTRACELLULAR VESICLE FUSIONS AND METHODS OF USING SAME
    Publication number: 20190125848
    Abstract: The present invention provides compositions and methods for treating cancer.
    Type: Application
    Filed: March 30, 2016
    Publication date: May 2, 2019
    Inventors: Donald Kufe, David Avigan
  • COMPOSITIONS AND METHODS OF TREATING CANCER
    Publication number: 20180085398
    Abstract: The present invention provides compositions and methods for treating cancer.
    Type: Application
    Filed: March 30, 2015
    Publication date: March 29, 2018
    Inventors: David AVIGAN, Jacalyn ROSENBLATT, Donald KUFE
  • COMPOSITIONS AND METHODS OF TREATING CANCER
    Publication number: 20180085350
    Abstract: The present invention provides compositions and methods for treating cancer.
    Type: Application
    Filed: March 30, 2016
    Publication date: March 29, 2018
    Inventors: David AVIGAN, Jacalyn ROSENBLATT, Donald KUFE
  • COMPOSITIONS AND METHODS OF TREATING ACUTE MYELOID LEUKEMIA
    Publication number: 20180078650
    Abstract: The present invention provides compositions and methods for treating acute myeloid leukemia.
    Type: Application
    Filed: March 30, 2015
    Publication date: March 22, 2018
    Inventors: David AVIGAN, Jacalyn ROSENBLATT, Donald KUFE
  • COMPOSITIONS AND METHODS OF TREATING RENAL CELL CANCER
    Publication number: 20180078626
    Abstract: The present invention provides compositions and methods for treating renal cell carcinoma
    Type: Application
    Filed: March 30, 2016
    Publication date: March 22, 2018
    Inventors: David AVIGAN, Jacalyn ROSENBLATT, Donald KUFE
  • COMPOSITIONS AND METHODS OF TREATING MULTIPLE MYELOMA
    Publication number: 20180071340
    Abstract: The present invention provides compositions and methods for treating multiple myeloma.
    Type: Application
    Filed: March 30, 2015
    Publication date: March 15, 2018
    Inventors: David AVIGAN, Jacalyn ROSENBLATT, Donald KUFE
  • Compositions and methods for treating cancer
    Patent number: 9663562
    Abstract: Compositions comprising SEQ ID NO: 1 and methods of treating a MUC16-expressing tumor cell are described.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: May 30, 2017
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Donald Kufe, Surender Kharbanda
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20160145313
    Abstract: The present invention provides compositions and methods of treating MUC16 expressing cancer.
    Type: Application
    Filed: March 13, 2014
    Publication date: May 26, 2016
    Inventors: Donald Kufe, Surender Kharbanda
  • Treating MUC1-expressing cancers with combination therapies
    Patent number: 9044421
    Abstract: The invention provides method of treating cancers that express mucin 1 (MUC1) by the administration of phosphatidylinositol 3-kinase (PI3-K) inhibitors in combination with MUC1-directed cancer therapies. The PI3-K inhibition may advantageously be combined with peptides that inhibit MUC1 oligomerization, or further with other standard anticancer therapies such as chemo-, radio- and surgical therapies.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: June 2, 2015
    Assignees: Genus Oncology, LLC, Dana-Farber Cancer Institute, Inc.
    Inventors: Donald Kufe, Surender Kharbanda
  • TREATING MUC1-EXPRESSING CANCERS WITH HELICASE INHIBITORS
    Publication number: 20150087598
    Abstract: The invention provides method of treating cancers that express MUC1 by the administration of eIF4A helicase inhibitors. These inhibitors may advantageously be combined with peptides that inhibit MUC1 oligomerization, or with other standard anticancer therapies such as chemo-, radio- and surgical therapies.
    Type: Application
    Filed: May 13, 2013
    Publication date: March 26, 2015
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventor: Donald Kufe