Patents by Inventor Donald L. Dawe

Donald L. Dawe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccines and methods for preventing and treating fescue toxicosis in herbivores
    Patent number: 6117427
    Abstract: The present invention provides an immunogenic compound the formula: ##STR1## wherein X is selected from the group consisting of methyl and hydrogen; wherein R.sub.1 is a suitable functional group of the lysergic ring;wherein R.sub.2 is an immunogenic protein; andwherein Y is a bridge to link R.sub.1 to R.sub.2.The present invention also provides purified polyclonal and monoclonal antibodies, specifically reactive with the immunogenic compound and reactive with the lysergic ring of ergopeptine and clavine alkaloids. The present invention further provides an antibody which is an anti-idiotype of the monoclonal antibody. Also provided are methods of prevention and treatment of fescue toxicosis utilizing the immunogenic compounds and antibodies of the present invention.
    Type: Grant
    Filed: June 23, 1997
    Date of Patent: September 12, 2000
    Assignees: University of Georgia Research Foundation, Inc., The United States of America as represented by the Secretary of Agriculture
    Inventors: Nicholas S. Hill, Frederick N. Thompson, Jr., John A. Stuedemann, Donald L. Dawe
  • Vaccines and methods for preventing and treating fescue toxicosis in herbivores
    Patent number: 5885576
    Abstract: The present invention provides an immunogenic compound comprising the formula: ##STR1## wherein X is selected from the group consisting of methyl and hydrogen; wherein R.sub.1 is a suitable functional group of the lysergic ring;wherein R.sub.2 is an immunogenic protein; andwherein Y is a bridge to link R.sub.1 to R.sub.2.The present invention also provides purified polyclonal and monoclonal antibodies specifically reactive with the immunogenic compound and reactive with the lysergic ring of ergopeptine and clavine alkaloids. The present invention further provides an antibody which is an anti-idiotype of the monoclonal antibody. Also provided are methods of prevention and treatment of fescue toxicosis utilizing the immunogenic compounds and antibodies of the present invention.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 23, 1999
    Assignees: The United States of America as represented by the Secretary of Agriculture, The University of Georgia Research Foundation, Inc.
    Inventors: Nicholas S. Hill, Frederick N. Thompson, Jr., John A. Stuedemann, Donald L. Dawe
  • Vaccines and methods for preventing and treating fescue toxicosis in herbivores
    Patent number: 5876726
    Abstract: The present invention provides an immunogenic compound comprising the formula: ##STR1## wherein X is selected from the group consisting of methyl and hydrogen; wherein R.sub.1 is a suitable functional group of the lysergic ring;wherein R.sub.2 is an immunogenic protein; andwherein Y is a bridge to link R.sub.1 to R.sub.2.The present invention also provides purified polyclonal and monoclonal antibodies specifically reactive with the immunogenic compound and reactive with the lysergic ring of ergopeptine and clavine alkaloids. The present invention further provides an antibody which is an anti-idiotype of the monoclonal antibody. Also provided are methods of prevention and treatment of fescue toxicosis utilizing the immunogenic compounds and antibodies of the present invention.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 2, 1999
    Assignees: Univ. of Georgia Research Foundation Inc., The United States of America as represented by Secretary of Agriculture
    Inventors: Nicholas S. Hill, Frederick N. Thompson, Jr., John A. Stuedemann, Donald L. Dawe
  • Vaccines and methods for preventing and treating Fescue toxicosis in herbivores
    Patent number: 5718900
    Abstract: An immunogenic compound comprising the formula: ##STR1## wherein X is selected from the group consisting of methyl and hydrogen; wherein R.sub.1 is a suitable functional group of the lysergic ring;wherein R.sub.2 is an immunogenic protein; andwherein Y is a bridge to link R.sub.1 to R.sub.2.Purified polyclonal and monoclonal antibodies specifically reactive with the immunogenic compound and reactive with the lysergic ring of ergopeptine and clavine alkaloids are described. An antibody which is an anti-idiotype of the monoclonal antibody is provided. Methods of prevention and treatment of fescue toxicosis utilizing the immunogenic compounds and antibodies of the present invention are provided.
    Type: Grant
    Filed: October 20, 1994
    Date of Patent: February 17, 1998
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Nicholas S. Hill, Frederick N. Thompson, Jr., John A. Stuedemann, Donald L. Dawe
  • Vaccines from taxonomically similar organisms
    Patent number: 4309416
    Abstract: A vaccine for protection against an infectious organism which cannot be readily cultured in vitro comprising an antigen derived from a taxonomically similar organism which is readily cultured in vitro. The method of preparation and the method of use are also disclosed.
    Type: Grant
    Filed: September 20, 1979
    Date of Patent: January 5, 1982
    Assignee: Research Corporation
    Inventors: John B. Gratzek, Beverly A. Goven, Donald L. Dawe