Patents by Inventor Donald L. Elbert
Donald L. Elbert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10682309Abstract: Disclosed herein is a device and method for regenerating tissue using a modular scaffold having a gradient of enzymatic degradability. The disclosure further relates to scaffolds made of microparticles comprising a cross-linked water-soluble polymer or cross-linked water-soluble polymers and a process for forming thereof.Type: GrantFiled: October 16, 2018Date of Patent: June 16, 2020Assignee: Washington UniversityInventors: Donald L. Elbert, Jacob Roam
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Publication number: 20190083389Abstract: Disclosed herein is a device and method for regenerating tissue using a modular scaffold having a gradient of enzymatic degradability. The disclosure further relates to scaffolds made of microparticles comprising a cross-linked water-soluble polymer or cross-linked water-soluble polymers and a process for forming thereof.Type: ApplicationFiled: October 16, 2018Publication date: March 21, 2019Applicant: Washington UniversityInventors: Donald L. Elbert, Jacob Roam
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Patent number: 10137082Abstract: Disclosed herein is a device and method for regenerating tissue using a modular scaffold having a gradient of enzymatic degradability. The disclosure further relates to scaffolds made of microparticles comprising a cross-linked water-soluble polymer or cross-linked water-soluble polymers and a process for forming thereof.Type: GrantFiled: August 22, 2017Date of Patent: November 27, 2018Assignee: Washington UniversityInventors: Donald L. Elbert, Jacob Roam
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Publication number: 20180049977Abstract: Disclosed herein is a device and method for regenerating tissue using a modular scaffold having a gradient of enzymatic degradability. The disclosure further relates to scaffolds made of microparticles comprising a cross-linked water-soluble polymer or cross-linked water-soluble polymers and a process for forming thereof.Type: ApplicationFiled: August 22, 2017Publication date: February 22, 2018Applicant: Washington UniversityInventors: Donald L. Elbert, Jacob Roam
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Publication number: 20150254421Abstract: A method of diagnosing an amyloid pathology in the central nervous system of a patient using measurements of enrichment kinetics of at least one amyloid-? isoform is provided. In addition, a model to predict enrichment kinetics of at least one amyloid-? isoform, methods of calibrating the model, and methods of using the model to diagnosing an amyloid pathology in the central nervous system of a patient are provided.Type: ApplicationFiled: May 20, 2015Publication date: September 10, 2015Inventors: Randall Bateman, Bruce W. Patterson, Donald L. Elbert
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Patent number: 8557288Abstract: The field of the disclosure relates to microparticles comprising a cross-linked water-soluble polymer or cross-linked water-soluble polymers and a process for forming thereof. Further, the field of the disclosure relates to coatings and scaffolds comprising microparticles and the processes for forming thereof.Type: GrantFiled: August 13, 2009Date of Patent: October 15, 2013Assignee: Washington UniversityInventors: Donald L. Elbert, Michael D. Nichols, Evan A. Scott
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Patent number: 7670605Abstract: The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments.Type: GrantFiled: August 15, 2008Date of Patent: March 2, 2010Assignees: Eidgenossische Technische Hochschule Zurich, Universitat ZurichInventors: Jeffrey A. Hubbell, Donald L. Elbert, Ronald Schoenmakers
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Publication number: 20100040688Abstract: The field of the disclosure relates to microparticles comprising a cross-linked water-soluble polymer or cross-linked water-soluble polymers and a process for forming thereof. Further, the field of the disclosure relates to coatings and scaffolds comprising microparticles and the processes for forming thereof.Type: ApplicationFiled: August 13, 2009Publication date: February 18, 2010Applicant: WASHINGTON UNIVERSITYInventors: Donald L. Elbert, Michael D. Nichols, Evan A. Scott
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Publication number: 20090264538Abstract: Compositions for coating biological and non-biological surfaces, which minimize or prevent cell-cell contact and tissue adhesion, and methods of preparation and use thereof are disclosed. Embodiments include polyethylene glycol/polylysine (PEG/PLL) block or comb-type copolymers with high molecular weight PLL (greater than 1000, more preferably greater than 100,000); PEG/PLL copolymers in which the PLL is a dendrimer which is attached to one end of the PEG; and multilayer compositions including alternating layers of polycationic and polyanionic materials. The multi-layer polymeric material is formed by the ionic interactions of a polycation and a polyanion. The molecular weights of the individual materials are selected such that the PEG portion of the copolymer inhibits cellular interactions, and the PLL portion adheres well to tissues.Type: ApplicationFiled: October 29, 2007Publication date: October 22, 2009Inventors: Jeffrey A. Hubbell, Donald L. Elbert, Curtis B. Herbert
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Patent number: 7316845Abstract: Compositions for coating biological and non-biological surfaces, which minimize or prevent cell-cell contact and tissue adhesion, and methods of preparation and use thereof, are disclosed. Embodiments include polyethylene glycol/polylysine (PEG/PLL) block or comb-type copolymers with high molecular weight PLL (greater than 1000, more preferably greater than 100,000); PEG/PLL copolymers in which the PLL is a dendrimer which is attached to one end of the PEG; and multilayer compositions including alternating layers of polycationic and polyanionic materials. The multi-layer polymeric material is formed by the ionic interactions of a polycation and a polyanion. The molecular weights of the individual materials are selected such that the PEG portion of the copolymer inhibits cellular interactions, and the PLL portion adheres well to tissues.Type: GrantFiled: March 19, 2004Date of Patent: January 8, 2008Assignee: California Institute of TechnologyInventors: Jeffrey A. Hubbell, Donald L. Elbert, Curtis B. Herbert
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Patent number: 7029688Abstract: The invention discloses materials that adsorb readily to the surfaces of body tissues in situ and provide a steric barrier between such tissues, so that tissue adhesions, which typically form following surgical procedures, are minimized. These materials contain a polymer of hydrophilic molecules such as polyethylene glycol (PEG) bound to a polymer that spontaneously adsorbs to biological tissue such as phenylboronic acid (PBA). The PEG-PBA co-polymer can be formed in a variety of geometries. The materials can also be used to coat prosthetics and other implants.Type: GrantFiled: March 28, 2003Date of Patent: April 18, 2006Assignee: California Institute of TechnologyInventors: Jeffrey A. Hubbell, Natalie D. Winblade, Donald L. Elbert
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Patent number: 6884628Abstract: Multifunctional, polyionic copolymers with molecular architectures and properties optimized for specific applications are synthesized on/or applied to substrate surfaces for analytical and sensing purposes. The coatings are particularly useful for suppression of non-specific interaction, adsorption or attachment of molecular or ionic components present in an analyte solution. Chemical, biochemical or biological groups that are able to recognize, interact with and bind specifically to target molecules in the material containing the analyte to be detected can be coupled to, integrated into, or absorbed to the multifunctional copolymers. These multifunctional copolymer coatings are compatible with a variety of different established methods to detect, sense and quantify the target molecule in an analyte.Type: GrantFiled: April 28, 2000Date of Patent: April 26, 2005Assignees: Eidgenossische Technische Hochschule Zurich, Universitat ZurichInventors: Jeffrey A. Hubbell, Marcus Textor, Donald L. Elbert, Stephanie Finken, Rolf Hofer, Nicholas D. Spencer, Laurence Ruiz-Taylor
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Patent number: 6813470Abstract: A roll comprising polymeric foam having a density of at least about 6 pounds per cubic foot and a compression force deflection of at least about 2.5 pounds per square inch. The roll may be used in image forming devices, and may be specifically employed as a toner added roll in electrophotographic image forming devices for toner applications.Type: GrantFiled: July 10, 2003Date of Patent: November 2, 2004Assignee: Lexmark International, Inc.Inventors: Donald L. Elbert, Michelle K. Morris
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Patent number: 6743521Abstract: Compositions for coating biological and non-biological surfaces, which minimize or prevent cell-cell contact and tissue adhesion, and methods of preparation and use thereof, are disclosed. Embodiments include polyethylene glycol/polylysine (PEG/PLL) block or comb-type copolymers with high molecular weight PLL (greater than 1000, more preferably greater than 100,000); PEG/PLL copolymers in which the PLL is a dendrimer which is attached to one end of the PEG; and multilayer compositions including alternating layers of polycationic and polyanionic materials. The multi-layer polymeric material is formed by the ionic interactions of a polycation and a polyanion. The molecular weights of the individual materials are selected such that the PEG portion of the copolymer inhibits cellular interactions, and the PLL portion adheres well to tissues.Type: GrantFiled: January 6, 2000Date of Patent: June 1, 2004Assignee: California Institute of TechnologyInventors: Jeffrey A. Hubbell, Donald L. Elbert, Curtis B. Herbert
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Patent number: 6652902Abstract: Boronic acid containing polymers are used to form bioinert gels and multilayer surface structures. These polymers form crosslinked hydrogels, which are highly swollen in water. The crosslinking can either be chemical or physical. Water soluble polymers containing boronic acid groups, such as phenylboronic acid (PBA), can be physically crosslinked by mixing the polymers in water with other polymers containing hydroxyls or carboxylic acids. Alternatively, surfaces can be treated by stepwise incubation with a solution of the boronic acid containing polymer, followed by incubation with a solution of a diol or carboxylic acid containing polymer. Many successive layers can be generated, increasing the thickness of the formed structure at each step.Type: GrantFiled: December 28, 2001Date of Patent: November 25, 2003Assignees: Eidgenossische Technische Hochschule Zurich, Universitat ZurichInventors: Jeffrey A. Hubbell, Donald L. Elbert, Natalie D. Winblade
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Publication number: 20030185787Abstract: The invention discloses materials that adsorb readily to the surfaces of body tissues in situ and provide a steric barrier between such tissues, so that tissue adhesions, which typically form following surgical procedures, are minimized. These materials contain a polymer of hydrophilic molecules such as polyethylene glycol (PEG) bound to a polymer that spontaneously adsorbs to biological tissue such as phenylboronic acid (PBA). The PEG-PBA co-polymer can be formed in a variety of geometries. The materials can also be used to coat prosthetics and other implants.Type: ApplicationFiled: March 28, 2003Publication date: October 2, 2003Applicant: California Institute of TechnologyInventors: Jeffrey A. Hubbell, Natalie D. Winblade, Donald L. Elbert
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Patent number: 6596267Abstract: The invention discloses materials that adsorb readily to the surfaces of body tissues in situ and provide a steric barrier between such tissues, so that tissue adhesions, which typically form following surgical procedures, are minimized. These materials contain a polymer of hydrophilic molecules such as polyethylene glycol (PEG) bound to a polymer that spontaneously adsorbs to biological tissue such as phenylboronic acid (PBA). The PEG-PBA co-polymer can be formed in a variety of geometries. The materials can also be used to coat prosthetics and other implants.Type: GrantFiled: August 27, 1998Date of Patent: July 22, 2003Assignee: California Institute of TechnologyInventors: Jeffrey A. Hubbell, Natalie D. Winblade, Donald L. Elbert
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Publication number: 20030087111Abstract: Compositions for coating biological and non-biological surfaces, which minimize or prevent cell-cell contact and tissue adhesion, and methods of preparation and use thereof, are disclosed. Embodiments include polyethylene glycol/polylysine (PEG/PLL) block or comb-type copolymers with high molecular weight PLL (greater than 1000, more preferably greater than 100,000); PEG/PLL copolymers in which the PLL is a dendrimer which is attached to one end of the PEG; and multilayer compositions including alternating layers of polycationic and polyanionic materials. The multi-layer polymeric material is formed by the ionic interactions of a polycation and a polyanion. The molecular weights of the individual materials are selected such that the PEG portion of the copolymer inhibits cellular interactions, and the PLL portion adheres well to tissues.Type: ApplicationFiled: January 6, 2000Publication date: May 8, 2003Inventors: JEFFREY A. HUBBELL, DONALD L. ELBERT, CURTIS B. HERBERT
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Publication number: 20020128234Abstract: Multifunctional, polyionic copolymers with molecular architectures and properties optimized for specific applications are synthesized on/or applied to substrate surfaces for analytical and sensing purposes. The coatings are particularly useful for suppression of non-specific interaction, adsorption or attachment of molecular or ionic components present in an analyte solution. Chemical, biochemical or biological groups can be coupled to, integrated into or absorbed to the multifunctional polymer that are able to recognize, interact with and bind specifically to target molecules in the material containing the analyte to be detected. These multifunctional polymer coatings are compatible with a variety of different established methods to detect, sense and quantify the target molecule in an analyte.Type: ApplicationFiled: April 28, 2000Publication date: September 12, 2002Inventors: Jeffrey A. Hubbell, Marcus Textor, Donald L. Elbert, Stephanie Finken, Rolf Hofer, Nicholas D. Spencer, Laurence Ruiz-Taylor
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Publication number: 20020061288Abstract: Boronic acid containing polymers are used to form bioinert gels and multilayer surface structures. These polymers form crosslinked hydrogels, which are highly swollen in water. The crosslinking can either be chemical or physical. Water soluble polymers containing boronic acid groups, such as phenylboronic acid (PBA), can be physically crosslinked by mixing the polymers in water with other polymers containing hydroxyls or carboxylic acids. Alternatively, surfaces can be treated by stepwise incubation with a solution of the boronic acid containing polymer, followed by incubation with a solution of a diol or carboxylic acid containing polymer. Many successive layers can be generated, increasing the thickness of the formed structure at each step.Type: ApplicationFiled: December 28, 2001Publication date: May 23, 2002Applicant: Eidgenossische Technische Hochschule ZurichInventors: Jeffrey A. Hubbell, Donald L. Elbert, Natalie D. Winblade