Patents by Inventor Donald L Gillian-Daniel

Donald L Gillian-Daniel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of lipoprotein secretion
    Patent number: 7517860
    Abstract: It has been discovered that the low density lipoprotein receptor (LDLR) degrades the lipoprotein apoB. Based on this observation, an artificial fusion protein has been designed containing an LDL receptor domain attached to a localization domain which causes retention of the fusion protein inside of a cell. The fusion protein is preferably retained in the endoplasmic reticulum of the cell, where the LDLR can degrade apoB. Data shows that the technique is effective in a mammal to reduce serum LDL cholesterol levels.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: April 14, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Alan D Attie, Donald L Gillian-Daniel, Paul W. Bates