Patents by Inventor Donald Nicholson

Donald Nicholson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060069038
    Abstract: The present invention encompasses a compound of Formula (I) useful as caspase active site probes. These probes can be used to determine whether a caspase has been activated, in cells or in tissues of animal models of various pathologies. Furthermore, through competition based assays, these caspase active site probes can be used to calculate the percentage of occupancy of active caspases by other, unlabeled inhibitors.
    Type: Application
    Filed: February 5, 2004
    Publication date: March 30, 2006
    Inventors: John Colucci, Andre Giroux, Yongxin Han, Nathalie Methot, Donald Nicholson, Sophie Roy, John Vaillancourt, Paul Tawa
  • Publication number: 20060019932
    Abstract: A method of treatment of rheumatoid arthritis administers an effective amount of a compound that inhibits phospho-diesterase-4.
    Type: Application
    Filed: September 2, 2003
    Publication date: January 26, 2006
    Inventors: Joseph Mancini, David Claveau, Chi Chan, Donald Nicholson, Denise Visco
  • Publication number: 20050112137
    Abstract: The present invention provides a method of producing autoantigens, compositions comprising autoantigenic fragments and methods of using autoantigenic fragments in the treatment of a condition associated with an autoimmune response. Also provided are assays for the detection or assessment of an autoimmune response.
    Type: Application
    Filed: October 29, 2004
    Publication date: May 26, 2005
    Inventors: Antony Rosen, Donald Nicholson, Livia Casciola-Rosen, Felipe Andrade, Sophie Roy, Nancy Thornberry
  • Patent number: 6547999
    Abstract: The present invention provides a method of preparing a cellulose solution suitable for extrusion as a seamless tubular film by providing a pulp of substantially open-ended fibrillated softwood fibers having a mean fiber length less than 2.0 mm and then dissolving the pulp in a suitable solvent to produce the cellulose solution. In addition, the present invention provides a method of preparing a cellulose food casing from a cellulose solution of the present invention.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: April 15, 2003
    Assignee: Viskase Corporation
    Inventors: Paul Edmund Ducharme, Jr., Myron Donald Nicholson, Norman Abbye Portnoy
  • Publication number: 20030039724
    Abstract: The present invention relates to the production of foodstuffs in casings coated with compositions of natural red colorants and/or liquid smoke, optionally antioxidants and optionally, a peeling aid, resulting in an enhanced reddish-smoky color on the foodstuffs, and the coloring compositions and casings used in such production.
    Type: Application
    Filed: March 22, 2002
    Publication date: February 27, 2003
    Inventors: Paul E. DuCharme, Myron Donald Nicholson
  • Patent number: 6143344
    Abstract: Bixin containing coloring compositions and self-coloring casings, particularly tubular cellulosic food casings, coated therewith, which compositions contain a dispersion of bixin in a water-soluble and/or alchol-soluble film forming agent, preferably hydroxypropylcellulose, a polyphosphate and optionally an antioxidant.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: November 7, 2000
    Assignee: Viskase Corporation
    Inventors: Shiu-Chung Jon, Rama Ramagopal, Myron Donald Nicholson
  • Patent number: 5955126
    Abstract: Bixin containing coloring compositions and self-coloring casings, particularly tubular cellulosic food casings, coated therewith, which compositions contain bixin, a water-soluble film forming agent, preferably hydroxypropylcellulose, a polyphosphate and optionally an antioxidant.
    Type: Grant
    Filed: September 21, 1993
    Date of Patent: September 21, 1999
    Assignee: Viskase Corporation
    Inventors: Shiu-Chung Jon, Rama Ramagopal, Myron Donald Nicholson
  • Patent number: 5744251
    Abstract: The present invention relates to compounded fibrous dope compositions of amine oxide cellulose solutions having a uniformly dispersed second fibrous material, methods of producing the compositions, and shaped articles such as fibers, paper, films, and food casings produced from the compositions.
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: April 28, 1998
    Assignee: Viskase Corporation
    Inventors: Paul Edmund DuCharme, Jr., Norman Abbye Protnoy, John Markulin, Myron Donald Nicholson
  • Patent number: 5702783
    Abstract: A cellulose food casing comprising a nonderivatized cellulose film precipitated in tubular form from an extruded thermoplastic solution of cellulose, an amine oxide cellulose solvent and water.
    Type: Grant
    Filed: August 16, 1995
    Date of Patent: December 30, 1997
    Assignee: Viskase Corporation
    Inventors: Myron Donald Nicholson, Edward Makoto Kajiwara, Paul Edmund DuCharme, Jr.
  • Patent number: 5700599
    Abstract: A battery separator of a cellulosic nonwoven substrate coated on at least one surface with a cellulose film and process for making such separator by contacting a nonwoven cellulosic textile substrate with a cellulose or cellulose derivative solution on at least one side of said substrate; converting the solution to a solid cellulose or cellulose derivative having a degree of polymerization of at least 500, preferably at least 600, to form a coated substrate; washing and drying the coated substrate to provide a battery separator having a absorption rate of at least 6 mm/5 min. and a 30% KOH absorption of at least 200 g/m.sup.2.
    Type: Grant
    Filed: January 12, 1996
    Date of Patent: December 23, 1997
    Inventors: Thomas Danko, Myron Donald Nicholson
  • Patent number: 5700600
    Abstract: A battery separator of a noncellulosic nonwoven substrate extrusion coated on at least one surface with a cellulose film and process for making such separator by contacting a nonwoven noncellulosic textile substrate with a cellulose or cellulose derivative solution on at least one side of said substrate; converting the solution to a solid cellulose or cellulose derivative, preferably having a degree of polymerization of at least 350, more preferably at least 600, to form a coated substrate; washing and drying the coated substrate to provide a battery separator, preferably having a absorption rate of at least 6 mm/5 min. and a 30% KOH absorption of at least 200 g/m.sup.2.
    Type: Grant
    Filed: January 12, 1996
    Date of Patent: December 23, 1997
    Inventors: Thomas Danko, Myron Donald Nicholson
  • Patent number: 5681936
    Abstract: Disclosed is a method for purifying Human interleukin-5 (IL-5) a single chromatographic step. After removing cells from a cell culture expressing human interleukin-5, IL-5 is purified by first adjusting the culture supernatant to the calculated pI value of mature IL-5 (pI=7.44) and then passing the conditioned supernatant through tandem linked anion- and cation-exchange columns. The resulting pass-through fraction contains the IL-5 and is devoid of all other contaminating proteins. An optional hydrophobic-interaction chromatography step is disclosed for positive selection of IL-5 and in order to concentrate the preparation. Pure IL-5 was recovered with a high overall yield (>90%), was N-glycosylated and was entirely homodimeric.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 28, 1997
    Assignee: Merck Frosst Canada, Inc.
    Inventor: Donald Nicholson
  • Patent number: 5628675
    Abstract: A pipe end trimming device for hand-held use in beveling the outer surface of the end of one pipe so that the beveled end may fit within the end of a similar diameter pipe for a strong connection therebetween. The preferred embodiment abrasive cylinders which are motor driven. An aligning arm with an adjustable aligning edge allows for quick, uniform beveling of different diameter pipe. Shielding adjacent to the abrasive cylinders protects the operator from debris thrown from the pipe during the beveling process.
    Type: Grant
    Filed: October 23, 1995
    Date of Patent: May 13, 1997
    Inventors: Terry S. Brown, Donald A. Nicholson
  • Patent number: 4828803
    Abstract: A device for use in a swimming pool to continuously dispense chlorine for sanitizing the water is disclosed which is advantageously made of five main segments which may be molded using only simple and inexpensive molds. The device is for the most part snapped together in a manner preventing relative rotation of the various components, with only a single adhesive operation required to seal the waterproof float assembly. The device is manufactured in a sturdy fashion, with all the parts being held firmly together in a unit not dependent on single axis connecting hardware.
    Type: Grant
    Filed: October 5, 1987
    Date of Patent: May 9, 1989
    Assignee: Aquality, Inc.
    Inventors: Donald Nicholson, Robert Nordmyer
  • Patent number: 4828804
    Abstract: A device for use in a swimming pool to prevent a floating chlorine feeder from spending an inordinate amount of time near a single location in a swimming pool due to water currents is disclosed which uses a tether to place the feeder in a central location in the swimming pool. A retainer is attachable to a floating feeder, and a retainer hook is attached to the edge of the pool furthest away from the location to which the feeder is drawn by water currents. A tether cord between the hook and the retainer keeps the feeder in the central location in the pool, where it is maintained by the currents in the pool.
    Type: Grant
    Filed: October 5, 1987
    Date of Patent: May 9, 1989
    Assignee: Aquaity, Inc.
    Inventors: Donald Nicholson, Robert Nordmyer, Greg Boyle
  • Patent number: 4825528
    Abstract: A device for use in a swimming pool to continuously dispense chlorine for sanitizing the water is disclosed which provides an indication when the device has either depleted or nearly depleted its chlorine supply. The float supporting the feeder and the chlorine is of two colors, one color on the top and a second color on the bottom. When an adequate amount of chlorine is contained in the feeder, the bottom color is below the waterline and not readily visible, and when the chlorine is depleted to a desired minimum amount, the bottom color is sufficiently above the waterline to provide a readily perceived visual warning of chlorine depletion.
    Type: Grant
    Filed: October 5, 1987
    Date of Patent: May 2, 1989
    Assignee: Aquality, Inc.
    Inventors: Donald Nicholson, Robert Nordmyer
  • Patent number: 4822571
    Abstract: A device for use in a swimming pool to continuously dispense chlorine for sanitizing the water is disclosed which has a metering valve designed for precise adjustment of the rate of dispersion of the chemical contained in the feeder. The metering mechanism is made of two segments, with a metering valve cap fitting over a metering valve body to adjust the apertures in the metering mechanism. Precise control is afforded both by a screw-type adjustment of aperture size and by a prevention of inadvertent readjustment of the metering mechanism caused by the device being bumped.
    Type: Grant
    Filed: October 5, 1987
    Date of Patent: April 18, 1989
    Assignee: Aquaity, Inc.
    Inventors: Donald Nicholson, Robert Nordmyer
  • Patent number: 4819293
    Abstract: The pool cleaning pole assembly includes an elongated cleaning pole having an improved adapter releasably connected to the bottom cleaning end thereof, and a cleaning accessory releasably connected to the adapter. The adapter includes(a) a first member having an upper hollow tubular portion releasably connected in the pole lower end by spring biased pins and bearing a base below the pole, and(b) a second member rotatably secured to the underside of the base for limited rotation. The second member has a bracket to which a pool cleaning accessory such as a brush, vacuum head, etc., is releasably connected. The adapter also includes a pin or the like inserted in aligned openings in the base and second member and connected to a Bowden wire or push rod passing up through the hollow tubular member and pole to the pole's upper end where it can be easily moved up and down by the operator to lock the second member against rotation or free it to rotate.
    Type: Grant
    Filed: January 11, 1988
    Date of Patent: April 11, 1989
    Assignee: Aquality, Inc.
    Inventor: Donald Nicholson
  • Patent number: 4024335
    Abstract: A solvent mixture consisting of dimethyl sulfoxide and formaldehyde is used for the hydroxy-alkylation of cellulose.
    Type: Grant
    Filed: May 4, 1976
    Date of Patent: May 17, 1977
    Assignee: Union Carbide Corporation
    Inventor: Myron Donald Nicholson
  • Patent number: 3993305
    Abstract: A training object ball for use in teaching billiard players to sight an object ball by the method known as "sighting by object ball displacement". The training ball is segmented at 30.degree. intervals to yield twelve legended segments which facilitate lining up one edge of a cue ball with the edge of the area of the training ball displaced by the cue ball.The method of training players to sight by object ball displacement includes the step of orienting the training ball so that an imaginary line extending from the center of the ball and through the boundary of two adjoining segments bisects the pocket to be made. An edge of the cue ball is lined up with a properly oriented segment boundary which corresponds to the edge of the area of the training ball that is displaced by the cue ball.Instructions for lining up a segment boundary which corresponds to the edge of the displaced area of the object ball with an edge of the cue ball is also disclosed.
    Type: Grant
    Filed: May 9, 1975
    Date of Patent: November 23, 1976
    Assignee: Anthony M. Lorusso
    Inventor: Donald A. Nicholson