Abstract: Provided herein are devices, methods, and systems for polynucleotide synthesis comprising a thermocycler comprising a plurality of individual chambers having a capability to control its own temperature setting and a machine learning for generating a recommendation of a design of experiment for polynucleotide synthesis.

Abstract: This invention discloses a handheld device to provide thermal therapy to tissue by contacting a surface heated with thermal energy to a patient's tissue. Thermal energy is continuously provided during operation. The handheld device comprises an assembly to provide heat operatively connected to a removable thermal energy applicator, the applicator is configured to provide different treatments, including heat application, debridement, and expression of the treated tissue or gland.

Abstract: A method of producing metal particles through electrolysis. A cathode having a plurality of active zones on a surface thereof is at least partially immersed in a reaction solution. The cathode is spaced from an anode also at least partially immersed in the reaction solution. A voltage potential is applied between the anode and cathode. Metal particles form on the active zones of the cathode. In order to promote the formation of good quality particles, a turbulent flow of the solution is maintained past one or more the active zones, and the current density in the active zones is maintained greater than about 5 kA/m2. The particles may be dislodged from the cathode after they have achieved a desired size.