Patents by Inventor Donald P. Bernstein

Donald P. Bernstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10524668
    Abstract: An apparatus a method for determining stroke volume by bioimpedance from a person having two or more spaced apart alternating current flow electrodes positionable on a person and two or more spaced apart voltage sensing electrodes positionable on the person and between the alternating current flow electrodes. A constant magnitude alternating current source is electrically connectable to the alternating current flow electrodes. A voltmeter is electrically connectable to the voltage sensing electrodes and configured to generate a voltage signal Z from a voltage sensed by the voltage sensing electrodes. A processing unit is electrically connectable with the voltmeter and configured to determine a stroke volume (SV) using the voltage signal Z and at least one of six equations.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: January 7, 2020
    Assignee: AEROBEX, INC.
    Inventor: Donald P. Bernstein
  • Publication number: 20190239756
    Abstract: An apparatus a method for determining stroke volume by bioimpedance from a person having two or more spaced apart alternating current flow electrodes positionable on a person and two or more spaced apart voltage sensing electrodes positionable on the person and between the alternating current flow electrodes. A constant magnitude alternating current source is electrically connectable to the alternating current flow electrodes. A voltmeter is electrically connectable to the voltage sensing electrodes and configured to generate a voltage signal Z from a voltage sensed by the voltage sensing electrodes. A processing unit is electrically connectable with the voltmeter and configured to determine a stroke volume (SV) using the voltage signal Z and at least one of six equations.
    Type: Application
    Filed: February 5, 2018
    Publication date: August 8, 2019
    Inventor: Donald P. Bernstein
  • Patent number: 9451888
    Abstract: An apparatus and method for determining stroke volume by bioimpedance from a person that includes two or more spaced apart alternating current flow electrodes positionable on a person's forearm, two or more spaced apart voltage sensing electrodes positionable on the person's forearm and between the alternating current flow electrodes, an alternating current source providing an alternating current to the current flow electrodes, a voltmeter configured to generate a voltage signal from a voltage sensed by the voltage sensing electrodes, and a processing unit configured to determine a stroke volume (SV) using the voltage signal and at least one of two equations that include, among other terms, the person's weight, a peak time rate of change of a transradioulnar impedance pulse variation (dZ/dtmax), a transradioulnar quasi-static base impedance (Z0), a systolic flow time (TSF), and a volume conductor (Vc).
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: September 27, 2016
    Assignee: CORDEUS, INC.
    Inventor: Donald P. Bernstein
  • Patent number: 8562538
    Abstract: In order to reliably determine the left-ventricular ejection time TLVE of a heart of a subject, at least two different measuring methods are employed. This includes in any case the derivation of a first waveform related to thoracic electrical bioimpedance or bioadmittance. A second waveform can be determined by using pulse oximetry, Doppler velocimetry, measurement of arterial blood pressure and measurement of peripheral electrical bioimpedance or bioadmittance. Depending on signal quality, the results obtained by each method are weighted and then averaged. The weighted average for left-ventricular ejection time is used as an input variable for cardiovascular monitoring methods, which determine objective measurements of cardiovascular function and performance. Such measurements include, but are not limited to, left ventricular ejection fraction, stroke volume, cardiac output, systolic time ratio, and indices of ventricular contractility.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: October 22, 2013
    Assignee: Osypka Medical GmbH
    Inventors: Markus J. Osypka, Donald P. Bernstein
  • Publication number: 20110190601
    Abstract: In order to reliably determine the left-ventricular ejection time TLVE of a heart of a subject, at least two different measuring methods are employed. This includes in any case the derivation of a first waveform related to thoracic electrical bioimpedance or bioadmittance. A second waveform can be determined by using pulse oximetry, Doppler velocimetry, measurement of arterial blood pressure and measurement of peripheral electrical bioimpedance or bioadmittance. Depending on signal quality, the results obtained by each method are weighted and then averaged. The weighted average for left-ventricular ejection time is used as an input variable for cardiovascular monitoring methods, which determine objective measurements of cardiovascular function and performance. Such measurements include, but are not limited to, left ventricular ejection fraction, stroke volume, cardiac output, systolic time ratio, and indices of ventricular contractility.
    Type: Application
    Filed: March 7, 2011
    Publication date: August 4, 2011
    Inventors: Markus J. Osypka, Donald P. Bernstein
  • Patent number: 7904141
    Abstract: In order to reliably determine the left-ventricular ejection time TLVE of a heart of a subject, at least two different measuring methods are employed. This includes in any case the derivation of a first waveform related to thoracic electrical bioimpedance or bioadmittance. A second waveform can be determined by using pulse oximetry, Doppler velocimetry, measurement of arterial blood pressure and measurement of peripheral electrical bioimpedance or bioadmittance. Depending on signal quality, the results obtained by each method are weighted and then averaged. The weighted average for left-ventricular ejection time is used as an input variable for cardiovascular monitoring methods, which determine objective measurements of cardiovascular function and performance. Such measurements include, but are not limited to, left ventricular ejection fraction, stroke volume, cardiac output, systolic time ratio, and indices of ventricular contractility.
    Type: Grant
    Filed: March 22, 2006
    Date of Patent: March 8, 2011
    Assignee: Osypka Medical GmbH
    Inventors: Markus J. Osypka, Donald P. Bernstein
  • Patent number: 7822470
    Abstract: In order to reliably determine the left-ventricular ejection time TLVE of a heart of a subject, at least two different measuring methods are employed. This includes in any case the derivation of a first waveform related to thoracic electrical bioimpedance or bioadmittance. A second waveform can be determined by using pulse oximetry, Doppler velocimetry, measurement of arterial blood pressure and measurement of peripheral electrical bioimpedance or bioadmittance. Depending on signal quality, the results obtained by each method are weighted and then averaged. The weighted average for left-ventricular ejection time is used as an input variable for cardiovascular monitoring methods, which determine objective measurements of cardiovascular function and performance. Such measurements include, but are not limited to, left ventricular ejection fraction, stroke volume, cardiac output, systolic time ratio, and indices of ventricular contractility.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: October 26, 2010
    Assignee: Osypka Medical GmbH
    Inventors: Markus J. Osypka, Donald P. Bernstein
  • Patent number: 7806830
    Abstract: Provided herein are methods and apparatus for stroke volume determination by bioimpedance from a patient's upper arm, or brachium, or a patient's thorax, utilizing pulsations of the arteries contained therein. The apparatus includes two or more spaced apart alternating current flow electrodes positioned on the patient's arm or thorax and two or more spaced apart voltage sensing electrodes positioned on the patient's arm or thorax and in-between alternating current flow electrodes. The system and method utilizes the mean value of the second time-derivative of the cardiogenically induced impedance variation of the patient using the measured voltage from the voltage sensors in calculating the stroke volume of the patient.
    Type: Grant
    Filed: June 21, 2005
    Date of Patent: October 5, 2010
    Assignee: Cordeus, Inc.
    Inventor: Donald P. Bernstein
  • Patent number: 7740590
    Abstract: Provided herein are methods and apparatus for stroke volume determination by bioimpedance from a patient's upper arm, or brachium, or a patient's thorax, utilizing pulsations of the arteries contained therein. The apparatus includes two or more spaced apart alternating current flow electrodes positioned on the patient's arm or thorax and two or more spaced apart voltage sensing electrodes positioned on the patient's arm or thorax and in-between alternating current flow electrodes. The system and method utilizes voltage sensed by the voltage sensing electrodes to calculate a cardiogenically induced impedance variation value of the patient, and to determine a stroke volume of the patient by multiplying the cardiogenically induced impedance variation value by a volume conductor VC and by a left ventricular ejection time TLVE.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: June 22, 2010
    Assignee: Cordeus, Inc.
    Inventor: Donald P. Bernstein
  • Publication number: 20090259132
    Abstract: Provided herein are methods and apparatus for stroke volume determination by bioimpedance from a patient's upper arm, or brachium, or a patient's thorax, utilizing pulsations of the arteries contained therein. The apparatus includes two or more spaced apart alternating current flow electrodes positioned on the patient's arm or thorax and two or more spaced apart voltage sensing electrodes positioned on the patient's arm or thorax and in-between alternating current flow electrodes. The system and method utilizes voltage sensed by the voltage sensing electrodes to calculate a cardiogenically induced impedance variation value of the patient, and to determine a stroke volume of the patient by multiplying the cardiogenicaly induced impedance variation value by a volume conductor VC and by a left ventricular ejection time TLVE.
    Type: Application
    Filed: June 22, 2009
    Publication date: October 15, 2009
    Inventor: Donald P. Bernstein
  • Patent number: 7186219
    Abstract: Doppler Velocimetry is a widely used method for estimating stroke volume (SV). The accuracy and reliability of its measurement however, is dependant on a) the correct assessment of the aortic valve cross-sectional area (CSA), and b) the maximal systolic velocity integral (SVI). The invention avoids the conventional assessment of aortic valve CSA by using a calibration method: a reference stroke volume SVREF is determined by a method different from Doppler velocimetry, e.g. by thoracic electrical bioimpedance (TEB), or thoracic electrical bioadmittance, measured via surface thorax electrodes (transthoracic approach) or via electrodes located directly on an esophageal catheter/probe (esophageal approach). In the latter case, if esophageal Doppler velocimetry is used, the same catheter can be used for the placement of the electrodes and for an ultrasound transducer.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: March 6, 2007
    Assignee: Osypka Medical GmbH
    Inventors: Markus J. Osypka, Donald P. Bernstein
  • Publication number: 20030163058
    Abstract: In order to reliably determine the left-ventricular ejection time TLVE of a heart of a subject, at least two different measuring methods are employed. This includes in any case the derivation of a first waveform related to thoracic electrical bioimpedance or bioadmittance. A second waveform can be determined by using pulse oximetry, Doppler velocimetry, measurement of arterial blood pressure and measurement of peripheral electrical bioimpedance or bioadmittance. Depending on signal quality, the results obtained by each method are weighted and then averaged. The weighted average for left-ventricular ejection time is used as an input variable for cardiovascular monitoring methods, which determine objective measurements of cardiovascular function and performance. Such measurements include, but are not limited to, left ventricular ejection fraction, stroke volume, cardiac output, systolic time ratio, and indices of ventricular contractility.
    Type: Application
    Filed: October 9, 2002
    Publication date: August 28, 2003
    Inventors: Markus J. Osypka, Donald P. Bernstein
  • Publication number: 20030163056
    Abstract: Doppler Velocimetry is a widely used method for estimating stroke volume (SV).
    Type: Application
    Filed: October 10, 2002
    Publication date: August 28, 2003
    Inventors: Markus J. Osypka, Donald P. Bernstein
  • Patent number: 6511438
    Abstract: The invention relates to an apparatus and a method for determining an approximate value for the stroke volume and the cardiac output of a person's heart. The apparatus and method employ a measured electrical impedance, or admittance, of a part of a person's body, namely, the thorax. This part of a person's body is chosen because its electrical impedance, or admittance, changes with time as a consequence of the periodic beating of the heart. Accordingly, the measured electrical admittance or impedance can provide information about the performance of the heart as a pump.
    Type: Grant
    Filed: April 3, 2001
    Date of Patent: January 28, 2003
    Assignee: Osypka Medical GmbH
    Inventors: Donald P. Bernstein, Markus J. Osypka
  • Publication number: 20020193689
    Abstract: The invention relates to an apparatus and a method for determining an approximate value for the stroke volume and the cardiac output of a person's heart. The apparatus and method employ a measured electrical impedance, or admittance, of a part of a person's body, namely, the thorax. This part of a person's body is chosen because its electrical impedance, or admittance, changes with time as a consequence of the periodic beating of the heart. Accordingly, the measured electrical admittance or impedance can provide information about the performance of the heart as a pump.
    Type: Application
    Filed: April 3, 2001
    Publication date: December 19, 2002
    Applicant: Osypka Medical GmbH
    Inventors: Donald P. Bernstein, Markus J. Osypka