Patents by Inventor Donald P. Bottaro

Donald P. Bottaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA encoding truncated hepatocyte growth factor variants
    Patent number: 6566098
    Abstract: The present invention relates to a novel truncated forms of hepatocyte growth factor (HGF) which specifically antagonizes the activity of HGF and to a novel truncated form of HGF that is a partial HGF agonist. In particular, the present invention relates to the purification, molecular cloning, recombinant expression of the truncated HGF variants and related pharmaceutical compositions. The present invention further relates to the utilization of the small HGF variants to either inhibit HGF mitogenesis or stimulate HGF mitogenesis in cells expressing the receptor for HGF.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 20, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Andrew M. L. Chan, Jeffrey S. Rubin, Donald P. Bottaro, Stuart A. Aaronson
  • Double-stranded RNA dependent protein kinase derived peptides to promote proliferation of cells and tissues in a controlled manner
    Patent number: 6326466
    Abstract: This invention relates to double-stranded RNA dependent protein kinase (PKR) peptide antagonists. More specifically, the invention relates to compositions and methods for antagonizing activation of double-stranded RNA dependent protein kinase (PKR) to stimulate eukaryotic cell proliferation. The invention relates to compositions and methods to inhibit activation of double-stranded RNA dependent protein kinase (PKR) to stimulate cell proliferation under conditions of cell cycle arrest, quiescence, reduced growth or cell death. The invention also relates to methods of protecting cells from HIV-1 pathogenesis using inhibitors of PKR.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: December 4, 2001
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Donald P. Bottaro, Raymond Petryshyn
  • Hepatic growth factor receptor is the MET proto-oncogene
    Patent number: 5648273
    Abstract: The present invention relates to a complex comprising hepatocyte growth factor (HGF) and met proto-oncogene protein. The present invention also relates to methods for detecting the presence of HGF ligand, met proto-oncogene receptor and methods for isolating either the ligand or receptor or complex comprising both. The present invention further relates to methods of diagnostic proliferative disorders and diseases such as hepatitis or hepatocarcinogenesis by detecting these ligand-receptor pairs.
    Type: Grant
    Filed: January 18, 1991
    Date of Patent: July 15, 1997
    Assignee: The United States of America, as represented by the Department of Health and Human Services
    Inventors: Donald P. Bottaro, Jeffery S. Rubin, Donna Faletto, Andrew M.-L. Chan, George F. Vande Woude, Stuart A. Aaronson
  • KGF receptor-derived antagonists of KGF binding
    Patent number: 5578566
    Abstract: The invention provides KGFR peptides which inhibit binding between keratinocyte growth factor (KGF) and its receptor. The sequence of the peptides is derived from regions in the receptor which specifically bind the growth factor. Also provided are pharmaceutical compositions and methods of inhibiting the interaction of KGF and the receptor in a patient to treat various carcinomas.
    Type: Grant
    Filed: May 4, 1993
    Date of Patent: November 26, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Donald P. Bottaro, Jeffrey S. Rubin, Stuart A. Aaronson
  • Expression cloning of a human phosphatase
    Patent number: 5512434
    Abstract: A method for the identification of related polypeptides, using an function-based selection criterion, is disclosed. A novel human phosphatase, and nucleotide sequences coding therefor, identified by the aforementioned method and designated VHR, is also disclosed.
    Type: Grant
    Filed: December 14, 1992
    Date of Patent: April 30, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Stuart A. Aaronson, Donald P. Bottaro, Toshio Ishibashi, Toru Miki