Patents by Inventor Donald P. Knowles

Donald P. Knowles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vitro parasite feeding system
    Patent number: 10888071
    Abstract: The system includes a feeding vessel having an inlet, an outlet, and a membrane positioned across an opening in the vessel. Parasites (preferably ticks) are allowed to attach themselves to the membrane so that as a feeding fluid (preferably blood) is circulated through the vessel, the parasites feed on the feeding fluid through the membrane.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: January 12, 2021
    Assignee: The United States of America, as Represented by The Secretary of Agriculture
    Inventors: Massaro W. Ueti, Glen A. Scoles, Donald P. Knowles, Jr.
  • GENETICALLY MODIFIED BABESIA PARASITES EXPRESSING PROTECTIVE TICK ANTIGENS AND USES THEREOF
    Publication number: 20170304416
    Abstract: The present invention relates to methods for stable transfection of Babesia parasites, and for vaccines conferring immunity against parasitic arthropods.
    Type: Application
    Filed: April 26, 2017
    Publication date: October 26, 2017
    Inventors: Carlos E. Suarez, Donald P. Knowles, Jr., Terry McElwain
  • IN VITRO PARASITE FEEDING SYSTEM
    Publication number: 20170238513
    Abstract: The system includes a feeding vessel having an inlet, an outlet, and a membrane positioned across an opening in the vessel. Parasites (preferably ticks) are allowed to attach themselves to the membrane so that as a feeding fluid (preferably blood) is circulated through the vessel, the parasites feed on the feeding fluid through the membrane.
    Type: Application
    Filed: February 23, 2016
    Publication date: August 24, 2017
    Inventors: Massaro W. Ueti, Glen A. Scoles, Donald P. Knowles, JR.
  • Genetically modified babesia parasites expressing protective tick antigens and uses thereof
    Patent number: 9707283
    Abstract: The present invention relates to methods for stable transfection of Babesia parasites, and for vaccines conferring immunity against parasitic arthropods.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: July 18, 2017
    Assignees: The United States of America, as represented by the Secretary of Agriculture, Washington State University
    Inventors: Carlos E. Suarez, Donald P. Knowles, Jr., Terry McElwain
  • GENETICALLY MODIFIED BABESIA PARASITES EXPRESSING PROTECTIVE TICK ANTIGENS AND USES THEREOF
    Publication number: 20160158327
    Abstract: The present invention relates to methods for stable transfection of Babesia parasites, and for vaccines conferring immunity against parasitic arthropods.
    Type: Application
    Filed: January 14, 2016
    Publication date: June 9, 2016
    Inventors: Carlos E. Suarez, Donald P. Knowles, JR., Terry McElwain
  • Genetically modified parasites expressing protective tick antigens and uses thereof
    Patent number: 9265818
    Abstract: The present invention relates to methods for stable transfection of Babesia parasites, and for vaccines conferring immunity against parasitic arthropods.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: February 23, 2016
    Assignees: The United States of America, as represented by the Secretary of Agriculture, Washington State University Research Foundation
    Inventors: Carlos E. Suarez, Donald P. Knowles, Jr., Terry F. McElwain
  • Genetically Modified Babesia Parasites Expressing Protective Tick Antigens and Uses Thereof
    Publication number: 20080317786
    Abstract: The present invention relates to methods for stable transfection of Babesia parasites, and for vaccines conferring immunity against parasitic arthropods.
    Type: Application
    Filed: May 5, 2008
    Publication date: December 25, 2008
    Applicants: The United States of America, As represented by the Secretary of Agriculture, Washington State University Research Foundation
    Inventors: Carlos E. Suarez, Donald P. Knowles, JR., Terry F. McElwain
  • Methods for detection of prion protein as an indication of transmissible spongiform encephalophathies
    Patent number: 6514707
    Abstract: Methods to detect prion or PrP-Sc protein as an indication of transmissible spongiform encephalopathies (TSEs), including preclinical detection of infected live animals, and postmortem detection methods, are described. In one aspect, the invention is directed to a non-invasive diagnostic assay using third eyelid-associated lymphoid tissue. In another aspect, the invention is directed to monoclonal antibodies that specifically bind a conserved epitope of PrP-Sc protein in fixed or frozen treated tissue.
    Type: Grant
    Filed: October 12, 2000
    Date of Patent: February 4, 2003
    Assignees: The United States of America as represented by the Secretary of Agriculture, Washington State University Research Foundation
    Inventors: Katherine I. O'Rourke, Donald P. Knowles, Timothy V. Baszler, Steven M. Parish
  • Serological identification of cattle, sheep or goats infected with anaplasma species
    Patent number: 6242571
    Abstract: The subject invention concerns the use of the conserved Anaplasma marginale major surface protein 5 gene and gene product and monoclonal antibody ANAF16C1 for the identification of animals persistently infected with Anaplasma species.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: June 5, 2001
    Inventors: Donald P. Knowles, Travis C. McGuire, Guy H. Palmer, William C. Davis, Terry F. McElwain
  • Antibodies for the detection of prion protein as an indication of transmissible spongiform encephalopathies
    Patent number: 6165784
    Abstract: Methods to detect prion or PrP-Sc protein as an indication of transmissible spongiform encephalopathies (TSEs), including preclinical detection of infected live animals, and postmortem detection methods, are described. In one aspect, the invention is directed to a non-invasive diagnostic assay using third eyelid-associated lymphoid tissue. In another aspect, the invention is directed to monoclonal antibodies that specifically bind a conserved epitope of PrP-Sc protein in fixed or frozen treated tissue.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: December 26, 2000
    Assignees: The United States of America as represented by the Secretary of Agriculture, Washington State University Research Foundation
    Inventors: Katherine I. O'Rourke, Donald P. Knowles, Timothy V. Baszler, Steven M. Parish
  • Serological identification of cattle, sheep or goats infected with anaplasma species
    Patent number: 5798219
    Abstract: The subject invention concerns the use of monoclonal antibody ANAF16C1 and Anaplasma species major surface protein-5 in the competitive inhibition format for the serological identification of animals infected with Anaplasma species.
    Type: Grant
    Filed: October 16, 1996
    Date of Patent: August 25, 1998
    Assignees: The United States of America as represented by the Secretary of Agriculture, Washington State University Research Foundation
    Inventors: Donald P. Knowles, Travis C. McGuire, Guy H. Palmer, William C. Davis, Terry F. McElwain
  • Merozoite proteins for use in detection of Babesia equi in horses using immunological techniques
    Patent number: 5643737
    Abstract: The present invention relates to a purified and isolated merozoite protein which is a specific indicator of infection by Babesia equi (B. equi) in horses. This protein contains a conserved region found in all strains of B. equi. It has a molecular weight of approximately 28 KDa and has been successfully purified and sequenced. The isolated and purified merozoite protein is used to prepare antibodies which can then be used in a competitive inhibition enzyme linked immunosorbent assay for the diagnosis of B. equi infection in horses.
    Type: Grant
    Filed: March 2, 1995
    Date of Patent: July 1, 1997
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Donald P. Knowles, Jr., Lance E. Perryman