Abstract: A computational personalized cognitive therapeutic system for treating patients with Mild Cognitive Impairment, Alzheimer's Disease, dementia and related conditions is described. The system includes a patient clinical database, a data aggregation layer and data pre-processor module, a digital cognitive therapy delivery module, a cognitive analytics engine, and a personalised cognitive platform configured to personalize a personalised cognitive digital therapy model. The personalised cognitive digital therapy model defines specific digital treatments to be delivered to the patient using the digital cognitive therapy delivery module each with a different mechanism of action. A range of digital cognitive biomarkers are collected along with behavioural and physiological biomarkers from wearable and medical devices which are processed by the cognitive analytics engine and uses AI/ML methods which are configured to estimate metrics and generate alerts.

Abstract: A system for protecting the body and frame of a vehicle from flying debris, particularly during a tire blowout includes a mounting apparatus configured to secure a protective shield, which may be a protective plate and/or fender, to an axle of a vehicle. In embodiments, the protective plate may be mounted to the axel via a mounting apparatus, and the fender may further be mounted to the mounting apparatus and/or protective plate. In some embodiments, the protective plate may be mounted directly to the axel, and the fender may further be mounted to the protective plate, whereby the plate may serve as the mounting apparatus.

Abstract: A system for protecting the body and frame of a vehicle from flying debris, particularly during a tire blowout includes a mounting apparatus configured to secure a protective shield, which may be a protective plate and/or fender, to an axle of a vehicle. In embodiments, the protective plate may be mounted to the axel via a mounting apparatus, and the fender may further be mounted to the mounting apparatus and/or protective plate. In some embodiments, the protective plate may be mounted directly to the axel, and the fender may further be mounted to the protective plate, whereby the plate may serve as the mounting apparatus.

Abstract: A system for protecting the body and frame of a vehicle from flying debris, particularly during a tire blowout includes a mounting apparatus configured to secure a protective shield, which may be a protective plate and/or fender, to an axle of a vehicle. In embodiments, the protective plate may be mounted to the axel via a mounting apparatus, and the fender may further be mounted to the mounting apparatus and/or protective plate. In some embodiments, the protective plate may be mounted directly to the axel, and the fender may further be mounted to the protective plate, whereby the plate may serve as the mounting apparatus.

Abstract: A system and method for measuring the movement of one or more limbs of an infant using a video system for the purpose of determining whether the infant suffers from or is at risk of suffering from a medical condition such as cerebral palsy.

Abstract: A system and method for measuring movements, utilizing one or more wireless accelerometers attached to one or more limbs of a human subject for the purpose of determining certain temporal and spatial gestures of the subject.

Abstract: A wire guide includes a helically wound coil having a proximal end and a distal end. A mandrel is positioned within the helically wound coil and terminates before the distal end of the helically wound coil. First and second safety wires are positioned within the helically wound coil and have proximal ends attached to the mandrel and distal ends attached to the distal end of the helically wound coil. The first and second safety wires are positioned on opposite sides of a distal tip of the mandrel and have contact surfaces facing the distal tip of the mandrel that have a shape other than convex. The interaction between the mandrel tip and the safety wires during a percutaneous vascular procedure inhibit mandrel protrusion and the potential tissue damage associated therewith.

Abstract: A system and method for measuring the movement of one or more limbs of an infant using a video system for the purpose of determining whether the infant suffers from or is at risk of suffering from a medical condition such as cerebral palsy.

Abstract: A conductivity counter and method of determining conductivity of a fluid sample are disclosed. The counter is suitable for high-speed, accurate counting of discrete events or items, such as cancer cells, passing through a fluid sample cell. A variable frequency current source is used to supply an excitation current to a sample cell connected in parallel with an inductance or the electrical equivalence of an inductance. This configuration can be accurately modeled as a parallel RLC circuit when the system is operated at a stable frequency. The current source frequency is tuned to the resonance frequency of the equivalent RLC circuit, which effectively eliminates the capacitive and inductive components of the impedance, leaving only purely resistive components. The output signal is due to perturbations in the fluid sample, such as passing cancer cells.

Abstract: A conductivity counter and method of determining conductivity of a fluid sample are disclosed. The counter is suitable for high-speed, accurate counting of discrete events or items, such as cancer cells, passing through a fluid sample cell. A variable frequency current source is used to supply an excitation current to a sample cell connected in parallel with an inductance or the electrical equivalence of an inductance. This configuration can be accurately modeled as a parallel RLC circuit when the system is operated at a stable frequency. The current source frequency is tuned to the resonance frequency of the equivalent RLC circuit, which effectively eliminates the capacitive and inductive components of the impedance, leaving only purely resistive components. The output signal is due to perturbations in the fluid sample, such as passing cancer cells.

Abstract: A conductivity counter and method of determining conductivity of a fluid sample are disclosed. The counter is suitable for high-speed, accurate counting of discrete events or items, such as cancer cells, passing through a fluid sample cell. A variable frequency current source is used to supply an excitation current to a sample cell connected in parallel with an inductance or the electrical equivalence of an inductance. This configuration can be accurately modeled as a parallel RLC circuit when the system is operated at a stable frequency. The current source frequency is tuned to the resonance frequency of the equivalent RLC circuit, which effectively eliminates the capacitive and inductive components of the impedance, leaving only purely resistive components. The output of the equivalent RLC circuit is connected to a high input impedance buffer amplifier and then to a phase sensitive detector, which detects the phase shift resulting from the equivalent RLC circuit.

Abstract: A wire guide includes a helically wound coil having a proximal end and a distal end. A mandrel is positioned within the helically wound coil and terminates before the distal end of the helically wound coil. First and second safety wires are positioned within the helically wound coil and have proximal ends attached to the mandrel and distal ends attached to the distal end of the helically wound coil. The first and second safety wires are positioned on opposite sides of a distal tip of the mandrel and have contact surfaces facing the distal tip of the mandrel that have a shape other than convex. The interaction between the mandrel tip and the safety wires during a percutaneous vascular procedure inhibit mandrel protrusion and the potential tissue damage associated therewith.

Abstract: A system and method for measuring movements, utilizing one or more wireless accelerometers attached to one or more limbs of a human subject for the purpose of determining certain temporal and spatial gestures of the subject.

Abstract: A catheter-insertion assembly includes a catheter with a proximal end and a distal end, a needle with a proximal end and a beveled distal end forming a sharp distal point, and an obturator with a proximal end and a distal end. The distal end of the obturator includes at least one bend. The bend allows the distal end of the obturator to protect the catheter from the sharp distal point of the needle during insertion of the needle through the catheter.

Abstract: The present invention provides an improved implantable medical device comprising at least one portion made of a radiopaque material selected from the group consisting of various palladium alloys, including a palladium alloy having, by weight, rhenium in the range of up to about 20 percent, and preferably rhenium at about 14 percent of the alloy, by weight. The present invention further provides a wire guide, an embolization coil, a marker band, a stent, a filter, an RF ablation coil, and an electrode having at least one portion made of the radiopaque material.

Abstract: A catheter-insertion assembly includes a catheter with a proximal end and a distal end, a needle with a proximal end and a beveled distal end forming a sharp distal point, and an obturator with a proximal end and a distal end. The distal end of the obturator includes at least one bend. The bend allows the distal end of the obturator to protect the catheter from the sharp distal point of the needle during insertion of the needle through the catheter.

Abstract: A conductivity counter and method of determining conductivity of a fluid sample are disclosed. The counter is suitable for high-speed, accurate counting of discrete events or items, such as cancer cells, passing through a fluid sample cell. A variable frequency current source is used to supply an excitation current to a sample cell connected in parallel with an inductance or the electrical equivalence of an inductance. This configuration can be accurately modeled as a parallel RLC circuit when the system is operated at a stable frequency. The current source frequency is tuned to the resonance frequency of the equivalent RLC circuit, which effectively eliminates the capacitive and inductive components of the impedance, leaving only purely resistive components. The output of the equivalent RLC circuit is connected to a high input impedance buffer amplifier and then to a phase sensitive detector, which detects the phase shift resulting from the equivalent RLC circuit.

Abstract: An electrophysiology catheter and method of use for mapping and ablation procedures. The catheter includes a braided conductive member at its distal end that can be radially expanded. The catheter can be used in endocardial and epicardial mapping and ablation procedures.

Abstract: The present invention provides an improved implantable medical device comprising at least one portion made of a radiopaque material selected from the group consisting of various palladium alloys, including a palladium alloy having, by weight, rhenium in the range of up to about 20 percent, and preferably rhenium at about 14 percent of the alloy, by weight. The present invention further provides a wire guide, an embolization coil, a marker band, a stent, a filter, an RF ablation coil, and an electrode having at least one portion made of the radiopaque material.

Abstract: A novel device and method for performing cardiac ablations includes a therapeutic instrument, for example, an ablation catheter, to which is mounted a flexible, braided electrode. The electrode configuration is selected so that it has a desired surface area for proper heat convection properties. RF energy is delivered to the electrode to heat and thereby ablate local heart tissue, with the electrode having good convection abilities to protect against coagulation, embolisms, and other undesirable effects of ablation procedures.