Abstract: Inhibition of the enzymes cholesterol ester hydrolase (CEH) and/or acyl coenzyme A: cholesterol acyltransferase (ACAT) results in the inhibition of the esterification of cholesterol and are therefore implicated in the inhibition of absorption of cholesterol and thus can lower serum cholesterol levels. Compounds of the formula: ##STR1## where Z is ##STR2## or --Ar.sup.1 --(CR.dbd.CR).sub.1-3 --Ar.sup.2, --AR.sup.1 --NR.sup.7 --AR.sup.2 and A is a linking group inhibit the enzymes CEH and/or ACAT (in vitro) and inhibit absorption of cholesterol.

Abstract: 9-Oxo-15-Substituted prostanoic acids, and intermediates for their preparation and for the preparation of other known prostaglandins are disclosed. The final products have bronchodilatory activity.

Abstract: There is disclosed herein a process for relieving bronchial spasm and facilitating breathing in warm-blooded animals which comprises administering to a warm-blooded animal in need thereof an amount sufficient to relieve bronchial spasm and facilitate breathing in said warm-blooded animal of a prostanoic acid of the formula: ##STR1## wherein R is ethynyl, A is --CH.sub.2 --CH.sub.2 -- and B is --CH.sub.2 --CH.sub.2 --; R is ethynyl, A is --CH.sub.2 --CH.sub.2 --, and B is trans --CH=CH--; or R is ethynyl, A is cis --CH=CH--; and B is trans --CH=CH--; and R.sup.1 is hydrogen, alkyl of from 1 to about 6 carbon atoms, alkali metal, or a pharmacologically acceptable cation derived from ammonia or a basic amine.

Abstract: 9-Oxo-15-substituted prostanoic acids, and intermediates for their preparation and for the preparation of other known prostaglandins are disclosed. The final products have bronchodilatory activity.

Abstract: 9-Oxo-15-Substituted prostanoic acids, and intermediates for their preparation and for the preparation of other known prostanglandins are disclosed. The final products have bronchodilatory activity.