Abstract: Disclosed is a refillable dispenser for separately dispensing each of two biological fluids contained therein for intermixing at a site outside of the dispenser to produce hemostasis or a tissue adhesive. The dispenser is compact, contains integrally formed internal reservoirs for the two biological fluids, an injection port on each reservoir for refilling the reservoir, and is designed for efficient filling without compromising the integrity of the sterile field. The dispenser is capable of dispensing the biological fluids, such as fibrinogen and thrombin, at either a focused point or in an aerosol mist. In addition, spray elements are disclosed for uniformly distributing the two biological fluids along either the interior surface or the exterior surface of an implantable vascular graft.

Abstract: Disclosed is a dispenser for separately dispensing each of two biological fluids contained therein for intermixing at a site outside of the dispenser to produce hemostasis or a tissue adhesive. The dispenser is compact, contains internal reservoirs of the two bioloical fluids, and is designed for efficient reloading with filled nonsterile containers without compromising the integrity of the sterile field. The dispenser is capable of dispensing the biological fluids, such as fibrinogen and thrombin, at either a focused point of in an aerosol mist. In addition, spray elements are disclosed for uniformly distributing the two biological fluids along either the interior surface or the exterior surface of an implantable vascular graft.

Abstract: An apparatus for diluting packed red blood cells contained in a transfusion bag is provided comprising a flexible, squeezable diluent bag for containing a diluent for diluting the red blood cells in the transfusion bag. A tubular assembly with one or more fittings is provided for permanently attaching the diluent bag to an input port of the transfusion bag. The fittings are adapted for preventing a non-destructive, non-removable separation of the two bags. A uni-directional flow fluid valve means is provided for preventing reverse fluid flow from the transfusion bag to the diluent bag.