Patents by Inventor Donald R. Branch

Donald R. Branch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazole derivatives and their uses thereof
    Patent number: 11090288
    Abstract: The present disclosure relates to a compound of formula or a pharmaceutically acceptable salt thereof; wherein U, R1, R2, R3 and Q are as defined herein. The disclosure also provides a method for treating or preventing a method for the prevention, treatment and/or alleviation of one or more autoimmune or alloimmune disease, pharmaceutical compositions and combination comprising a therapeutically effective amount of a compound, as defined herein.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: August 17, 2021
    Assignees: UNIVERSITY HEALTH NETWORK, CANADIAN BLOOD SERVICES
    Inventors: Donald R. Branch, Lakshmi P. Kotra
  • PYRAZOLE DERIVATIVES AND THEIR USES THEREOF
    Publication number: 20190022066
    Abstract: The present disclosure relates to a compound of formula or a pharmaceutically acceptable salt thereof; wherein U, R1, R2, R3 and Q are as defined herein. The disclosure also provides a method for treating or preventing a method for the prevention, treatment and/or alleviation of one or more autoimmune or alloimmune disease, pharmaceutical compositions and combination comprising a therapeutically effective amount of a compound, as defined herein.
    Type: Application
    Filed: September 25, 2018
    Publication date: January 24, 2019
    Inventors: Donald R. Branch, Lakshmi P. Kotra
  • Pyrazole derivatives and their uses thereof
    Patent number: 10130609
    Abstract: The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof; wherein U, R1, R2, R3 and Q are as defined herein. The disclosure also provides a method for treating or preventing a method for the prevention, treatment and/or alleviation of one or more autoimmune or alloimmune disease, pharmaceutical compositions and combination comprising a therapeutically effective amount of a compound, as defined herein.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: November 20, 2018
    Assignees: UNIVERSITY HEALTH NETWORK, CANADIAN BLOOD SERVICES
    Inventors: Donald R. Branch, Lakshmi P. Kotra
  • PYRAZOLE DERIVATIVES AND THEIR USES THEREOF
    Publication number: 20160022640
    Abstract: The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof; wherein U, R1, R2, R3 and Q are as defined herein. The disclosure also provides a method for treating or preventing a method for the prevention, treatment and/or alleviation of one or more autoimmune or alloimmune disease, pharmaceutical compositions and combination comprising a therapeutically effective amount of a compound, as defined herein.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 28, 2016
    Inventors: Donald R. Branch, Lakshmi P. Kotra
  • INHIBITION OF FcyR-MEDIATED PHAGOCYTOSIS WITH REDUCED IMMUNOGLOBULIN PREPARATIONS
    Publication number: 20120321621
    Abstract: The invention relates to pharmaceutical compositions for inhibiting Fc?R-mediated phagocytosis that include a reduced immunoglobulin inhibitor of Fc?R-mediated phagocytosis, such as anti-D, in combination with a pharmaceutically acceptable carrier. The invention also relates to methods for treating or preventing an autoimmune or alloimmune disease that include administering to a subject in need thereof a therapeutically effective amount of a reduced immunoglobulin inhibitor of Fc?R-mediated phagocytosis.
    Type: Application
    Filed: August 27, 2012
    Publication date: December 20, 2012
    Inventor: Donald R. Branch
  • INHIBITION OF FcyR-MEDIATED PHAGOCYTOSIS WITH REDUCED IMMUNOGLOBULIN PREPARATIONS
    Publication number: 20100047249
    Abstract: The invention relates to pharmaceutical compositions for inhibiting Fc?R-mediated phagocytosis comprising a reduced immunoglobulin inhibitor of Fc?R-mediated phagocytosis, such as anti-D, in combination with a pharmaceutically acceptable carrier. The invention also relates to methods for treating or preventing an autoimmune or alloimmune disease comprising administering to a subject in need thereof a therapeutically effective amount of a reduced immunoglobulin inhibitor of Fc?R-mediated phagocytosis.
    Type: Application
    Filed: August 20, 2009
    Publication date: February 25, 2010
    Inventor: Donald R. Branch
  • Methods for the early detection of HIV infection
    Patent number: 6248515
    Abstract: Methods for the early detection of HIV infection by detecting a change in signal transduction mediator activity, particularly, an enzyme mediator, more particularly a member of the src protein tyrosine kinase family. The methods are applicable to HIV detection with serum, plasma, blood cell lysates, urine and saliva media. The methods provide a very early, reliable, specific and sensitive test of seronegative HIV infection that is affordable and practical on a large scale.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: June 19, 2001
    Inventors: Donald R. Branch, David J. Phipps
  • Method for the early detection of HIV infection
    Patent number: 6235466
    Abstract: Methods for the early detection of HIV infection by detecting a change in signal transduction mediator activity, particularly, an enzyme mediator, more particularly a member of the src protein tyrosine kinase family. The methods are applicable to HIV detection with serum, plasma, blood cell lysates, urine and saliva media. The methods provide a very early, reliable, specific and sensitive test of seronegative HIV infection that is affordable and practical on a large scale.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: May 22, 2001
    Inventors: Donald R. Branch, David J. Phipps