Patents by Inventor Donald R. Griffin
Donald R. Griffin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11931480Abstract: A hydrogel material for modulating an immune response in a human subject or other mammal includes a collection of microgel particles having one or more network cross linker components, wherein the microgel particles, when exposed to an endogenous or exogenous annealing agent, links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having interstitial spaces formed between the microgel particles and wherein the collection of microgel particles further includes at least one of an antigen and an adjuvant.Type: GrantFiled: February 14, 2017Date of Patent: March 19, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Westbrook Weaver, Tatiana Segura, Philip Scumpia, Donald R. Griffin
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Patent number: 11931481Abstract: A hydrogel material for use in a human subject or other mammal includes a collection of microgel particles having one or more network cross linker components, wherein the microgel particles, when exposed to an endogenous or exogenous annealing agent, links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having pores formed between the microgel particles wherein the pores are substantially devoid of hydrogel.Type: GrantFiled: July 30, 2022Date of Patent: March 19, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Westbrook Weaver, Tatiana Segura, Jaekyung Koh, Philip Scumpia, Donald R. Griffin
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Publication number: 20230190995Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.Type: ApplicationFiled: September 24, 2022Publication date: June 22, 2023Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
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Publication number: 20220370686Abstract: A hydrogel material for use in a human subject or other mammal includes a collection of microgel particles having one or more network cross linker components, wherein the microgel particles, when exposed to an endogenous or exogenous annealing agent, links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having pores formed between the microgel particles wherein the pores are substantially devoid of hydrogel.Type: ApplicationFiled: July 30, 2022Publication date: November 24, 2022Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Westbrook Weaver, Tatiana Segura, Jaekyung Koh, Philip Scumpia, Donald R. Griffin
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Patent number: 11464886Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.Type: GrantFiled: January 8, 2021Date of Patent: October 11, 2022Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
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Publication number: 20210138105Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.Type: ApplicationFiled: January 8, 2021Publication date: May 13, 2021Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
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Patent number: 10912860Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.Type: GrantFiled: September 11, 2017Date of Patent: February 9, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
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Publication number: 20200306413Abstract: A hydrogel material for modulating an immune response in a human subject or other mammal includes a collection of microgel particles having one or more network cross linker components, wherein the microgel particles, when exposed to an endogenous or exogenous annealing agent, links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having interstitial spaces formed between the microgel particles and wherein the collection of microgel particles further includes at least one of an antigen and an adjuvant.Type: ApplicationFiled: February 14, 2017Publication date: October 1, 2020Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Westbrook Weaver, Tatiana Segura, Jaekyung Koh, Philip Scumpia, Donald R. Griffin
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Publication number: 20200085859Abstract: Disclosed herein are therapeutic polymer gel systems for promoting healing of a wound or surgical site in a subject. The therapeutic polymer gel forms a microporous network and may be applied or injected in a fluid form and annealed or crosslinked after application to the wound or surgical site. The microporous gel may optionally contain various therapeutic agents throughout the therapeutic polymer gel which are released.Type: ApplicationFiled: October 8, 2019Publication date: March 19, 2020Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
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Publication number: 20190151497Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.Type: ApplicationFiled: January 31, 2019Publication date: May 23, 2019Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
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Publication number: 20180078671Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.Type: ApplicationFiled: December 1, 2017Publication date: March 22, 2018Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
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Publication number: 20170368224Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.Type: ApplicationFiled: September 11, 2017Publication date: December 28, 2017Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
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Publication number: 20160279283Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.Type: ApplicationFiled: June 10, 2016Publication date: September 29, 2016Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia