Patents by Inventor Donald R. Hawken

Donald R. Hawken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Splice variants of human G-protein coupled receptor HGPRBMY29 (HGPRMBY29SV2)
    Patent number: 8124729
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: August 9, 2007
    Date of Patent: February 28, 2012
    Assignee: Bristol-Myers Squibb Company
    Inventors: John N. Feder, Chandra S. Ramanathan, Gabriel A. Mintier, David K. Bol, Donald R. Hawken
  • SPLICE VARIANTS OF HUMAN G-PROTEIN COUPLED RECEPTOR HGPRBMY29 (HGPRMBY29SV2)
    Publication number: 20120010385
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: August 9, 2007
    Publication date: January 12, 2012
    Inventors: John N. Feder, Chandra S. Ramanathan, Gabriel A. Mintier, David Bol, Donald R. Hawken
  • Polynucleotides encoding two novel human G-protein coupled receptors, HGPRBMY28 and HGPRBMY29, and splice variants thereof
    Publication number: 20080213918
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: August 13, 2007
    Publication date: September 4, 2008
    Inventors: John N. Feder, Chandra S. Ramanathan, Gabriel A. Mintier, David Bol, Donald R. Hawken
  • Polynucleotides encoding a novel human G-protein coupled receptor splice variant HGPRBMY29sv1
    Patent number: 7049096
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: May 23, 2006
    Assignee: Bristol-Meyers Squibb Company
    Inventors: John N. Feder, Chandra S. Ramanathan, Gabriel A. Mintier, David Bol, Donald R. Hawken
  • Novel human G-protein coupled receptor, HGPRBMY8, expressed highly in brain
    Publication number: 20040214317
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, and diseases or disorders related to the brain are illustrated.
    Type: Application
    Filed: November 13, 2003
    Publication date: October 28, 2004
    Inventors: Peter Battaglino, John N. Feder, Gabriel Mintier, Thomas C. Nelson, Chandra S. Ramanathan, Ryan Westphal, Angela M. Cacace, Lauren E. Barber, Donald R. Hawken, Michael G. Kornacker
  • Novel human G-protein coupled receptor, HGPRBMY18, expressed highly in pituitary gland, colon carcinoma, and lung cancer cells
    Publication number: 20040161823
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, endocrine conditions, neurological conditions, and diseases or disorders related to the pituitary gland, colon, breast, lungs, kidney, and prostate are illustrated.
    Type: Application
    Filed: January 30, 2004
    Publication date: August 19, 2004
    Inventors: John N. Feder, Gabriel Mintier, Chandra S. Ramanathan, Donald R. Hawken
  • Novel human G-protein coupled receptor, HGPRBMY9, expressed highly in brain and testes
    Publication number: 20040147732
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, urological conditions, and diseases or disorders related to the brain and testes are illustrated. Additional methods for treating, diagnosing, preventing, and screening for disorders associated with Alzheimer's disease, proliferative lung disorders, and disorders associated with aberrant NFkB and/or E-selectin expression and/or function are illustrated.
    Type: Application
    Filed: October 7, 2003
    Publication date: July 29, 2004
    Inventors: John N. Feder, Gabriel Mintier, Chandra S. Ramanathan, Donald R. Hawken, Angela M. Cacace, Kelly L. Bennett
  • Novel human G-protein coupled receptor, HGPRBMY4, and methods of use thereof
    Publication number: 20040121330
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and polypeptide of the present invention. Methods for treating, diagnosing, preventing, and screening for neurological, cardiovascular, and prostate-, colon-, breast-, or lung-related conditions or disorders are described.
    Type: Application
    Filed: December 18, 2002
    Publication date: June 24, 2004
    Inventors: John N. Feder, Gabriel A. Mintier, Chandra S. Ramanathan, Donald R. Hawken, Angela Cacace, Lauren E. Barber, Michael G. Kornacker, Rolf-Peter Ryseck, Kelly L. Bennett, Thomas C. Nelson
  • Novel human G-protein coupled receptor, HGPRBMY3, expressed highly in immune -and colon-related tissues
    Publication number: 20030186360
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, immunological conditions, and diseases or disorders related to immune tissues, brain, and colon are illustrated.
    Type: Application
    Filed: September 26, 2001
    Publication date: October 2, 2003
    Inventors: John N. Feder, Gabe Mintier, Chandra S. Ramanathan, Donald R. Hawken, Angela Cacace, Lauren Barber, Michael G. Kornacker
  • Novel human G-protein coupled receptor, HGPRBMY7, expressed highly in spinal cord
    Publication number: 20030186265
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, immunological diseases, neurological conditions, and diseases or disorders related to the spinal cord and brain, as well as breast and colon, are illustrated.
    Type: Application
    Filed: September 25, 2002
    Publication date: October 2, 2003
    Inventors: Peter Battaglino, John N. Feder, Gabriel Mintier, Chandra S. Ramanathan, Ryan Westphal, Donald R. Hawken, Angela M. Cacace, Lauren E. Barber, Michael G. Kornacker, David K. Bol
  • Novel human G-protein coupled receptor, HGPRBMY3, expressed highly in immune- and colon- related tissues
    Publication number: 20030175748
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, immunological conditions, and diseases or disorders related to immune tissues, brain, breast, cervix, kidney, and colon are illustrated.
    Type: Application
    Filed: October 10, 2002
    Publication date: September 18, 2003
    Inventors: John N. Feder, Gabriel Mintier, Chandra S. Ramanathan, Donald R. Hawken, Angela Cacace, Lauren E. Barber, Michael G. Kornacker
  • Novel human G-protein coupled receptor, HGPRBMY6, expressed highly in small intestine
    Publication number: 20030170671
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing and screening for disorders associated with aberrant cell growth and those related to the small intestine and colon are illustrated.
    Type: Application
    Filed: September 27, 2002
    Publication date: September 11, 2003
    Inventors: John N. Feder, Gabriel Mintier, Chandra S. Ramanathan, Donald R. Hawken, Angela M. Cacace, Lauren E. Barber, Michael G. Kornacker, Thomas C. Nelson, David K. Bol
  • Novel human G-protein coupled receptor, HGPRBMY18, expressed highly in pituitary gland and colon carcinoma cells
    Publication number: 20030129653
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, endocrine conditions, neurological conditions, and diseases or disorders related to the pituitary gland, colon, breast, lungs, and prostate are illustrated.
    Type: Application
    Filed: September 30, 2002
    Publication date: July 10, 2003
    Inventors: John N. Feder, Gabriel Mintier, Chandra S. Ramanathan, Donald R. Hawken
  • Novel human G-protein coupled receptor, HGPRBMY9, expressed highly in brain and testes
    Publication number: 20030096300
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, urological conditions, and diseases or disorders related to the brain and testes are illustrated.
    Type: Application
    Filed: September 26, 2001
    Publication date: May 22, 2003
    Inventors: John N. Feder, Gabe Mintier, Chandra S. Ramanathan, Donald R. Hawken, Angela Cacace
  • Polynucleotides encoding two novel human G-protein coupled receptors, HGPRBMY28 and HGPRBMY29, and splice variants thereof
    Publication number: 20030096347
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: April 11, 2002
    Publication date: May 22, 2003
    Inventors: John N. Feder, Chandra S. Ramanathan, Gabriel A. Mintier, David Bol, Donald R. Hawken
  • Novel human G-protein coupled receptor, HGPRBMY8, expressed highly in brain
    Publication number: 20030054444
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, and diseases or disorders related to the brain are illustrated.
    Type: Application
    Filed: November 14, 2001
    Publication date: March 20, 2003
    Inventors: Peter Battaglino, John N. Feder, Gabe Mintier, Thomas C. Nelson, Chandra S. Ramanathan, Ryan Westphal, Angela Cacace, Lauren Barber, Donald R. Hawken, Michael G. Kornacker
  • Novel human G-protein coupled receptor, HGPRBMY6, expressed highly in small intestine
    Publication number: 20030044892
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, aritisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing and screening for disorders associated with aberrant cell growth and those related to the small intestine and colon are illustrated.
    Type: Application
    Filed: September 26, 2001
    Publication date: March 6, 2003
    Inventors: John N. Feder, Gabe Mintier, Chandra S. Ramanathan, Donald R. Hawken, Angela Cacace, Lauren Barber, Michael G. Kornacker
  • Novel human G-protein coupled receptor, HGPRBMY5, expressed highly in brain and ovarian tissues
    Publication number: 20030027323
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/ or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, and diseases or disorders related to the brain, ovaries, thymus, or lungs are illustrated.
    Type: Application
    Filed: September 26, 2001
    Publication date: February 6, 2003
    Inventors: John N. Feder, Gabe Mintier, Chandra S. Ramanathan, Donald R. Hawken
  • Novel human G-protein coupled receptor, HGPRBMY4, expressed highly in prostate, colon, and lung
    Publication number: 20030022237
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/ or polypeptide of the present invention. Methods for treating, diagnosing, preventing, and screening for neurological, cardiovascular, and prostate-, colon-, or lung-related conditions and/or disorders.
    Type: Application
    Filed: September 26, 2001
    Publication date: January 30, 2003
    Inventors: John N. Feder, Gabe Mintier, Chandra S. Ramanathan, Donald R. Hawken, Angela Cacace, Lauren Barber, Michael G. Kornacker
  • Novel human G-protein coupled receptor, HGPRBMY7, expressed highly in spinal cord
    Publication number: 20030022183
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, immunological diseases, neurological conditions, and diseases or disorders related to the spinal cord and brain, as well as breast and colon, are illustrated.
    Type: Application
    Filed: September 26, 2001
    Publication date: January 30, 2003
    Inventors: Peter M. Battaglino, John N. Feder, Gabe Mintier, Chandra S. Ramanathan, Ryan S. Westphal, Donald R. Hawken, Angela Cacace, Lauren Barber, Michael G. Kornacker