Abstract: Provided are compositions that can be employed for generating microporous gel systems. In some embodiments, the compositions include at least one sub-population of soft hydrogel microparticles with a Youngs modulus of less than 50 kPa and at least one sub-population of stiff hydrogel microparticles with a Young's modulus of greater than 90 kPa. Also provided are methods for generating the compositions, methods for treating bone and/or cartilage defects in subject using the disclosed compositions, methods for treating osteoarthritis using the disclosed compositions, and methods for providing orthopedic implants to subjects.

Abstract: Non-degradable, non-immunogenic microporous hydrogel compositions are provided. Such hydrogel compositions consist of flowable hydrogel particles comprising a bioinert polymeric backbone, including for example a poly(ethylene glycol)(PEG)-based polymeric backbone, an annealing component comprising a physiologically-stable, radically polymerizable alkene, including for example methacrylamide, and a heparin compound. Methods of treating glottic incompetence and/or providing laryngeal reconstruction are also provided. Such methods consist of providing a subject suffering from glottic incompetence and/or in need of laryngeal reconstruction, and administering a non-degradable, non-immunogenic microporous hydrogel composition disclosed herein.