Patents by Inventor Donald S. Prough
Donald S. Prough has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240130709Abstract: Apparatus and methods are described for ultrasound guided optoacoustic monitoring to provide diagnostic information for many clinical applications of blood oxygenation in blood vessels and in tissues including for early diagnosis and management of circulatory shock (including that induced by hemorrhage). In certain embodiments provided herein, methods and apparatus for optoacoustics for measurement of blood oxygenation in the innominate vein are provided. In certain embodiments provided herein, are methods and apparatus for articulating an angle between an ultrasound probe and subject body to identify an optimum position for an optoacoustic probe to measure blood oxygenation in a target blood vessel or tissue.Type: ApplicationFiled: December 13, 2023Publication date: April 25, 2024Inventors: DONALD S. PROUGH, III, YURIY PETROV, CHARLES HOUSSIERE, IRENE PETROV, TRIS MILLER
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Publication number: 20230347182Abstract: Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.Type: ApplicationFiled: June 30, 2023Publication date: November 2, 2023Inventors: Rinat O. ESENALIEV, Maria-Adelaide MICCI, Donald S. PROUGH
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Patent number: 11730979Abstract: Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.Type: GrantFiled: October 5, 2017Date of Patent: August 22, 2023Assignee: Board of Regents, The University of Texas SystemInventors: Rinat O. Esenaliev, Maria-Adelaide Micci, Donald S. Prough
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Patent number: 11109782Abstract: Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant's head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.Type: GrantFiled: January 16, 2019Date of Patent: September 7, 2021Assignee: Board of Regents, The University of Texas SystemInventors: Rinat O. Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Y. Petrov, C. Joan Richardson
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Patent number: 11045121Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.Type: GrantFiled: January 22, 2019Date of Patent: June 29, 2021Assignee: Noninvasix, Inc.Inventors: Rinat Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Petrov, George Saade, Gayle L. Olson, Tommy G. Cooper
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Publication number: 20190231239Abstract: Apparatus and methods are described for ultrasound guided optoacoustic monitoring to provide diagnostic information for many clinical applications blood oxygenation in blood vessels and in tissues including for early diagnosis and management of circulatory shock (including that induced by hemorrhage). In certain embodiments provided herein, methods and apparatus for optoacoustics for measurement of blood oxygenation in the innominate vein are provided.Type: ApplicationFiled: September 12, 2017Publication date: August 1, 2019Applicant: Board of Regents, The University of Texas SystemInventors: Donald S. Prough, Michael P Kinsky, Rinat O. Esenaliev, Irene Y. Petrov, Yuriy Petrov
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Publication number: 20190224500Abstract: Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.Type: ApplicationFiled: October 5, 2017Publication date: July 25, 2019Applicant: Board of Regents, The University of Texas SystemInventors: Rinat O. ESENALIEV, Maria-Adelaide MICCI, Donald S. PROUGH
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Publication number: 20190216376Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.Type: ApplicationFiled: January 22, 2019Publication date: July 18, 2019Inventors: Rinat ESENALIEV, Donald S. PROUGH, Yuriy PETROV, Irene PETROV, George SAADE, Gayle L. OLSON, Tommy G. COOPER
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Patent number: 10307088Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.Type: GrantFiled: July 8, 2015Date of Patent: June 4, 2019Assignee: The Board of Regents of the University of TexasInventors: Rinat Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Petrov, George Saade, Gayle L. Olson
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Publication number: 20190142316Abstract: Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant's head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.Type: ApplicationFiled: January 16, 2019Publication date: May 16, 2019Applicant: Board of Regents, The University of Texas SystemInventors: Rinat O. Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Y. Petrov, C. Joan Richardson
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Patent number: 10231656Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.Type: GrantFiled: July 8, 2015Date of Patent: March 19, 2019Assignees: Noninvasix, Inc., The Board of Regents of The University of TexasInventors: Rinat Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Petrov, George Saade, Gayle L. Olson, Tommy G. Cooper
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Patent number: 10226206Abstract: Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant's head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.Type: GrantFiled: March 11, 2016Date of Patent: March 12, 2019Assignee: The Board Of Regents of the University Of Texas SystemInventors: Rinat O. Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Y. Petrov, C. Joan Richardson
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Patent number: 10206607Abstract: Medical apparatus are disclosed for optoacoustic monitoring of an indwelling unit of the apparatus, where the indwelling unit includes one or more optical components capable of directing pulsed light into an overlying tissue. The apparatus also include one or more acoustic components in contact with an exterior surface of the tissue to detect induced pressure waves producing an acoustic output analyzed with an optoacoustic unit to monitor and confirm proper placement of the indwelling unit. Methods for using the apparatus are also disclosed.Type: GrantFiled: April 30, 2012Date of Patent: February 19, 2019Assignee: The Board of Regents of the University of Texas SystemInventors: Donald S. Prough, Rinat O. Esenaliev, Yuriy Petrov, Irene Petrov
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Publication number: 20160262674Abstract: Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant's head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.Type: ApplicationFiled: March 11, 2016Publication date: September 15, 2016Applicant: Board of Regents, The University of Texas SystemInventors: Rinat O. Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Y. Petrov, C. Joan Richardson
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Patent number: 9380967Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.Type: GrantFiled: July 8, 2015Date of Patent: July 5, 2016Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Rinat Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Petrov, George Saade, Gayle L. Olson
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Publication number: 20160015304Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.Type: ApplicationFiled: July 8, 2015Publication date: January 21, 2016Inventors: Rinat ESENALIEV, Donald S. PROUGH, Yuriy PETROV, Irene PETROV, George SAADE, Gayle L. OLSON, Tommy G. COOPER
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Publication number: 20160007895Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.Type: ApplicationFiled: July 8, 2015Publication date: January 14, 2016Inventors: Rinat ESENALIEV, Donald S. PROUGH, Yuriy PETROV, Irene PETROV, George SAADE, Gayle L. OLSON
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Publication number: 20160007892Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.Type: ApplicationFiled: July 8, 2015Publication date: January 14, 2016Inventors: Rinat ESENALIEV, Donald S. PROUGH, Yuriy PETROV, Irene PETROV, George SAADE, Gayle L. OLSON
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Patent number: 9167993Abstract: New methods and systems for noninvasive glucose monitoring and sensing with electromagnetic waves or ultrasound are disclosed. The methods are based on absolute or relative measurement of tissue dimensions (or changes in the dimensions) including, but not limited to: thickness, length, width, diameter, curvature, roughness as well as time of flight of ultrasound and optical pulses and optical thickness, which change with changing blood glucose concentrations. By measuring noninvasively absolute or relative changes in at least one dimension of at least one tissue or tissue layer or absolute or relative changes in time of flight of ultrasound or optical pulses, one can monitor blood glucose concentration noninvasively.Type: GrantFiled: March 9, 2012Date of Patent: October 27, 2015Inventors: Rinat O. Esenaliev, Donald S. Prough
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Publication number: 20140058253Abstract: Medical apparatus are disclosed for optoacoustic monitoring of an indwelling unit of the apparatus, where the indwelling unit includes one or more optical components capable of directing pulsed light into an overlying tissue. The apparatus also include one or more acoustic components in contact with an exterior surface of the tissue to detect induced pressure waves producing an acoustic output analyzed with an optoacoustic unit to monitor and confirm proper placement of the indwelling unit. Methods for using the apparatus are also disclosed.Type: ApplicationFiled: April 30, 2012Publication date: February 27, 2014Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Donald S. Prough, Rinat O. Esenaliev, Yuriy Petrov, Irene Petrov