Abstract: Provided herein are combinations of therapies that provide for the treatment, including regression, of atherosclerosis and/or improvement of cardiovascular outcomes. Generally described, this includes a first, non-PCSK9 LDL-C lowering agent (such as a statin or other non-PCSK9 LDL-C lowering therapy), combined with a second, PCSK9 inhibitor therapy (such as a PCSK9 antibody or anti-RNA). The application of both therapies, at adequately elevated levels so as to reduce the LDL-C level of the subject to very low levels, for an adequate period of time, has been determined to provide an added benefit of further protection from atherosclerosis and improve a subject's cardiovascular outcomes.

Abstract: An ophthalmic lens having an electronic system for imaging at least a wearer's eye including a ciliary muscle and/or a lens to determine lens accommodation by propagating a sound pressure wave(s) into the eye and determining a relative position of the ciliary muscle from one or more detections of the partially reflected sound pressure wave(s) including, for example, amplitude and/or time and in other embodiments frequency. The ophthalmic lens includes at least one ultrasound module having at least one transducer such as a pair of transmit and receive transducers, a transceiver transducer or a plurality of transducers. The ultrasound module includes additional components for the creation and reception of the sound pressure wave(s). The ophthalmic lens may be a contact lens or an intraocular lens.

Abstract: Programmable timer circuits are disclosed. One timer circuit may include a reference circuit configured to generate a bias current, a current controlled oscillator configured to receive the bias current c, and a frequency divider network configured to divide an output of the oscillator. The timer circuit may be capable of timing for 24 hour period, while using less than 5nA of quiescent current.

Abstract: Disclosed are methods for identifying bio-molecules with desired properties (or which are most suitable for a round of directed evolution) from complex bio-molecule libraries or sets of such libraries. Some embodiments of the present disclosure provide methods for virtually screening proteins for beneficial properties. Some embodiments of the present disclosure provide methods for virtually screening enzymes for desired activity and/or selectivity for catalytic reactions involving particular substrates. Some embodiments combine screening and directed evolution to design and develop proteins and enzymes having desired properties. Systems and computer program products implementing the methods are also provided.

Abstract: This disclosure relates to modeling and visualization of vibration mechanics in residual space, and includes systems and methods for vibrational analysis. In one embodiment, a method includes acquiring, by at least one sensor, vibrational data and an operational mode of rotating equipment. The method may then proceed with determining, by an equipment controller communicatively coupled to the sensor, at least one vibrational vector based on the vibrational data. The method may determine, by the equipment controller and based on a model, an expected vibrational vector for the operational mode. The method may calculate, by the equipment controller, a residual vector as a difference between the vibrational vector and the expected vector. The method may also determine, by the equipment controller, at least one abnormality associated with the rotating equipment based on the residual vector.

Abstract: Disclosed are methods for identifying bio-molecules with desired properties (or which are most suitable for a round of directed evolution) from complex bio-molecule libraries or sets of such libraries. Some embodiments of the present disclosure provide methods for virtually screening proteins for beneficial properties. Some embodiments of the present disclosure provide methods for virtually screening enzymes for desired activity and/or selectivity for catalytic reactions involving particular substrates. Some embodiments combine screening and directed evolution to design and develop proteins and enzymes having desired properties. Systems and computer program products implementing the methods are also provided.

Abstract: A pair of ophthalmic lens having an electronic system is described herein for communicating between them using ultrasound transducers for creating a sound pressure wave(s) propagated through the eyes and the optic nerve of the wearer of the contact lenses. The ophthalmic lenses include at least one ultrasound module having at least one transducer such as a pair of transmit and receive transducers and a transceiver transducer that are optic nerve facing. The ultrasound module includes additional components for the transmission and receipt of the sound pressure wave(s). In an alternative embodiment, there is one ultrasound module with a multiplexer connected to a plurality of transducers. In at least one embodiment, the sound pressure wave(s) encodes a message between the ophthalmic lenses.

Abstract: A device and method for automated computer controlled manufacture of assemblies composed of discrete linked product segments includes reciprocating product segment grippers having surface features engageable with the product segments, at least one robotic manipulating device whereby the product segments may be engage the product segment grippers. A fastener-insertion device is included to engage a fastener linking the product segments together, a segment container containing interchangeable product segments. The device also includes a machine vision device for verifying the identity of the selected product segment. A computer operated control mechanism with associated hardware and software operates and controls the reciprocating product segment grippers, the robotic manipulator arms, the machine vision device, and the fastener-insertion device.

Abstract: A trigger bar for a semi-automatic firearm including a continuous U-shaped body and a single tab extending outward from a base of the U-shaped body. The tab is offset from a centerline located between legs of the U-shaped body. The trigger bar is configured to operate the sear when the legs are coupled to a sear assembly of the firearm, and only the single tab is coupled to a trigger of the firearm via a trigger bar slot of the trigger.

Abstract: A first contact lens and a second contact lens each having an electronic system is described herein for spatially locating the position of a wearer's nose relative to each lens. The contact lenses include at least one ultrasound module having at least one transducer such as a pair of transmit and receive transducers, a transceiver transducer or a plurality of transducers. The ultrasound module includes additional components for the creation and reception of the sound pressure wave(s).

Abstract: A ophthalmic lens having an electronic system is described herein for detecting blinks using at least one transducer emitting a sound pressure wave(s) to be reflected from the inside of the eyelid when the wearer is blinking or otherwise has his/her eyelid closed. The ophthalmic lens in further embodiments may communicate with a second ophthalmic lens to confirm the detection of a blink. In at least one embodiment, the ophthalmic lens includes at least one ultrasound module having at least one transducer such as a pair of transmit and receive transducers, a transceiver transducer or a plurality of transducers. The ultrasound module includes additional components for the creation and reception of the sound pressure wave(s). The ophthalmic lenses may be contact lenses or intraocular lenses.

Abstract: An ophthalmic lens having an electronic system is described herein for providing an identification in response to a signal or inquiry and/or receiving an identification tag. The ophthalmic lenses include at least one ultrasound module having at least one transducer such as a transmit transducer or a piezoelectric transducer. The ophthalmic lens further includes an identification module for generating an identification in response to a signal and powering the ultrasound module to propagate at least one sound pressure wave embodying the identification. In at least one embodiment, the identification data is encoded after manufacture of the device. The ophthalmic lens may be a contact lens or an intraocular lens.

Abstract: A progressive stage load distributing and absorbing system that lies below a superstructure material which is exposed to percussive forces. The progressive stage load distributing and absorbing system is interposed between the superstructure material and a foundation. The system has a barrier layer that lies below the superstructure material and an underlayment infrastructure positioned below the barrier layer. Included in the underlayment infrastructure are hat-shaped absorbing members that have a relatively compliant stage subsystem and one or more relatively stiff stage subsystems.

Abstract: A load distributing and absorbing system that lies below a superstructure material which is exposed to percussive forces. The load distributing and absorbing system is interposed between the superstructure material and a foundation. The system has a barrier layer that lies below the superstructure material and an underlayment infrastructure positioned below the barrier layer. Included in the underlayment infrastructure are hat-shaped absorbing members.

Abstract: Disclosed herein are combination therapies for the treatment of heart failure using a cardiac myosin activator, such as omecamtiv mecarbil, and a sinus node If current inhibitor, such as ivabradine. Also disclosed herein are compositions comprising a cardiac myosin activator and a sinus node If current inhibitor.

Abstract: A monitoring probe is for monitoring a fluid inside a process system. The probe has a first portion comprising a plurality of optical sensors provided along a waveguide for monitoring a plurality of measurands from the fluid, wherein each optical sensor is configured to monitor at least one measurand from the fluid. The first portion of the probe is elongate and is configured to be inserted through an aperture of the process system into a chamber of the process system such that the optical sensors are in communication with the fluid. The probe further has an attachment element for securing the probe to the process system.