Abstract: Devices and methods for treating tissue injuries and augmenting the maturation and differentiation of stem cell populations are provided. The devices comprises ultrasonic oscillators capable of variable frequency output, user-selectable based on the tissue being treated. The devices produce therapeutic ultrasound that is pulsed and has a modulated amplitude and varying waveform of variable intensity.

Abstract: Systems, devices, and methods for delivering ultrasonic treatment to a subject. An ultrasound therapy device includes a waveform generator, one or more transducers, one or more sensors, and a controller. In some embodiments, the waveform generator is configured to generate a first driving signal having at least a first waveform segment and a second waveform segment different from the first waveform segment.