Patents by Inventor Donald Siegel

Donald Siegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190194332
    Abstract: The invention relates to Anti-TEM 1 antibodies or antigen-binding fragments thereof, yeast libraries comprising the same, and prophylactic, diagnostic, and therapeutic methods using the same.
    Type: Application
    Filed: December 24, 2018
    Publication date: June 27, 2019
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Nathalie Scholler, Alzhi Zhao, Donald Siegel, George Coukos
  • Patent number: 10263305
    Abstract: A rechargeable magnesium oxygen battery including a negative electrode, a positive electrode, a non-aqueous magnesium ion electrolyte layer between the negative and positive electrodes, and an oxygen restrictor. The oxygen restrictor is configured to restrict oxygen crossover from the positive electrode to the negative electrode.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: April 16, 2019
    Assignees: DENSO CORPORATION, The Regents of The University of Michigan
    Inventors: Junichi Naruse, Donald Siegel
  • Patent number: 10160809
    Abstract: The invention relates to Anti-TEM 1 antibodies or antigen-binding fragments thereof, yeast libraries comprising the same, and prophylactic, diagnostic, and therapeutic methods using the same.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: December 25, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Nathalie Scholler, Aizhi Zhao, Donald Siegel, George Coukos
  • Patent number: 9960467
    Abstract: A non-aqueous type magnesium oxygen battery including a negative electrode, a positive electrode, a non-aqueous magnesium ion conductor, and a promoter is described. The negative electrode is configured to absorb magnesium and release magnesium ion. The positive electrode is configured to produce a discharge product that includes magnesium and oxygen during a discharge process of the battery. The non-aqueous magnesium on conductor is between the negative electrode and the positive electrode. The promoter is included with the positive electrode. The promoter is configured to promote MgO2 (magnesium peroxide) production during the discharge process of the battery.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: May 1, 2018
    Assignees: DENSO CORPORATION, The Regents of The University of Michigan
    Inventors: Junichi Naruse, Donald Siegel, Jeffrey Smith, Gulin Vardar, Charles Monroe
  • Publication number: 20170281793
    Abstract: The invention relates to Anti-TEM 1 antibodies or antigen-binding fragments thereof, yeast libraries comprising the same, and prophylactic, diagnostic, and therapeutic methods using the same.
    Type: Application
    Filed: January 20, 2017
    Publication date: October 5, 2017
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Nathalie SCHOLLER, Aizhi Zhao, Donald Siegel, George Coukos
  • Publication number: 20170155177
    Abstract: A non-aqueous type magnesium oxygen battery including a negative electrode, a positive electrode, a non-aqueous magnesium ion conductor, and a promoter is described. The negative electrode is configured to absorb magnesium and release magnesium ion. The positive electrode is configured to produce a discharge product that includes magnesium and oxygen during a discharge process of the battery. The non-aqueous magnesium on conductor is between the negative electrode and the positive electrode. The promoter is included with the positive electrode. The promoter is configured to promote MgO2 (magnesium peroxide) production during the discharge process of the battery.
    Type: Application
    Filed: December 1, 2015
    Publication date: June 1, 2017
    Inventors: Junichi NARUSE, Donald SIEGEL, Jeffrey SMITH, Gulin VARDAR, Charles MONROE
  • Publication number: 20170155108
    Abstract: A rechargeable magnesium oxygen battery including a negative electrode, a positive electrode, a non-aqueous magnesium ion electrolyte layer between the negative and positive electrodes, and an oxygen restrictor. The oxygen restrictor is configured to restrict oxygen crossover from the positive electrode to the negative electrode.
    Type: Application
    Filed: December 1, 2015
    Publication date: June 1, 2017
    Inventors: Junichi NARUSE, Donald SIEGEL
  • Patent number: 9658224
    Abstract: The present invention relates to novel methods for detecting a member of a known binding pair in a sample, including a cell, where one member of the pair (termed the “receptor”) is expressed by a bacteriophage, which phage is then used to detect the presence of the other member of the pair (termed the “ligand” or “target”). Rather than detecting the binding of the phage using antibody-based technology, the present invention relates to detecting marker molecule associated with the phage. In one aspect, the invention relates to identifying an antigen-bearing moiety (e.g., a red blood cell antigen) of interest present on a cell, e.g., a red blood cell, using antibody-displaying bacteriophage, as well as detecting anti-red blood cell auto- or alloantibodies and/or complement in a sample, using antiglobulin reagent-displaying bacteriophage and detecting a marker molecule associated with the phage. In one aspect, the phenotype of the phage is not linked with the genotype of the phage.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: May 23, 2017
    Assignees: The Trustees of the University of Pennsylvania, The Scripps Research Insitute
    Inventors: Donald Siegel, Carlos F. Barbas, III
  • Patent number: 9556272
    Abstract: The invention relates to Anti-TEM 1 anti-bodies or antigen-binding fragments thereof, yeast libraries comprising the same, and prophylactic, diagnostic, and therapeutic methods using the same.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: January 31, 2017
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Nathalie Scholler, Aizhi Zhao, Donald Siegel, George Coukos
  • Publication number: 20160285108
    Abstract: A rechargeable magnesium oxygen battery, which can be recharged with high efficiency, including a negative electrode, a positive electrode, and an electrolyte catalyst. The negative electrode is configured to release magnesium ions during discharge of the battery, and configured to precipitate elemental magnesium during charging of the battery. The positive electrode is configured to precipitate discharge products that include at least magnesium and oxygen during discharge of the battery, and for releasing magnesium ions during charging of the battery. The electrolyte catalyst is between the negative electrode and the positive electrode. The electrolyte catalyst can be any suitable compound configured to facilitate adsorption of at least one of the electrolyte catalyst and anions thereof on the discharge product.
    Type: Application
    Filed: December 1, 2015
    Publication date: September 29, 2016
    Inventors: Junichi NARUSE, Hidehiko HIRAMATSU, Donald SIEGEL, Jeffrey SMITH, Gulin VARDAR, Charles MONROE
  • Publication number: 20120294799
    Abstract: The invention relates to Anti-TEM 1 anti-bodies or antigen-binding fragments thereof, yeast libraries comprising the same, and prophylactic, diagnostic, and therapeutic methods using the same.
    Type: Application
    Filed: November 12, 2010
    Publication date: November 22, 2012
    Inventors: Nathalie Scholler, Aizhi Zhao, Donald Siegel, George Coukos
  • Publication number: 20100015595
    Abstract: The present invention relates to novel methods for detecting a member of a known binding pair in a sample, including a cell, where one member of the pair (termed the “receptor”) is expressed by a bacteriophage, which phage is then used to detect the presence of the other member of the pair (termed the “ligand” or “target”). Rather than detecting the binding of the phage using antibody-based technology, the present invention relates to detecting marker molecule associated with the phage. In one aspect, the invention relates to identifying an antigen-bearing moiety (e.g., a red blood cell antigen) of interest present on a cell, e.g., a red blood cell, using antibody-displaying bacteriophage, as well as detecting anti-red blood cell auto- or alloantibodies and/or complement in a sample, using antiglobulin reagent-displaying bacteriophage and detecting a marker molecule associated with the phage. In one aspect, the phenotype of the phage is not linked with the genotype of the phage.
    Type: Application
    Filed: November 14, 2006
    Publication date: January 21, 2010
    Applicants: THE TRUSTEE OF THE UNIVERSITY OF PENNSYLVANIA, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Donald Siegel, Carlos F. Barbas, III
  • Publication number: 20090181026
    Abstract: The present invention is directed to methods which exploit the discovery of tomoregulin-2 (TR2) in amyloid plaques in Alzheimer's disease using TR2-sepcific antibodies; methods and compositions comprising TR2-specific antibodies for the diagnosis and treatment of Alzheimer's disease; methods and compositions comprising immunizing TR2 peptides to induce an immune response, thereby reducing/inhibiting plaque formation; and methods and compositions comprising enzyme inhibitors to blocking the enzymatic release of TR2 ectodomain from the cell surface or inhibit TR2 protein translation by RNA interference technology.
    Type: Application
    Filed: June 6, 2008
    Publication date: July 16, 2009
    Inventors: Donald A. Siegel, May Huang
  • Publication number: 20090123475
    Abstract: The invention includes Rh(D) binding proteins, including antibodies, and DNA encoding such proteins. Methods of generating such proteins and DNAs are also included.
    Type: Application
    Filed: January 9, 2006
    Publication date: May 14, 2009
    Inventor: Donald Siegel
  • Publication number: 20060177440
    Abstract: The invention includes Rh(D) binding proteins, including antibodies, and DNA encoding such proteins. Methods of generating such proteins and DNAs are also included.
    Type: Application
    Filed: January 9, 2006
    Publication date: August 10, 2006
    Inventor: Donald Siegel
  • Publication number: 20050282252
    Abstract: The invention includes Rh(D) binding proteins, including antibodies, and DNA encoding such proteins. Methods of generating such proteins and DNAs are also included.
    Type: Application
    Filed: February 22, 2005
    Publication date: December 22, 2005
    Inventor: Donald Siegel
  • Publication number: 20050208596
    Abstract: The present invention relates to novel methods of identifying and producing an anti-platelet autoantibody. More preferably, the invention relates to identification and production of a human monoclonal anti-platelet autoantibody. Additionally, the invention relates to methods for producing and identifying inhibitors of an anti-platelet autoantibody binding with a platelet, or a platelet component. Moreover, the invention relates to methods for treating or alleviating a disease, disorder or condition mediated by an anti-platelet autoantibody specifically binding with a platelet, or a component thereof, such as, but not limited to, idiopathic thrombocytopenic purpura, among others.
    Type: Application
    Filed: December 23, 2004
    Publication date: September 22, 2005
    Inventor: Donald Siegel
  • Publication number: 20050191622
    Abstract: The present invention relates to novel methods for detecting a member of a known binding pair in a sample, including a cell, where one member of the pair (termed the “receptor”) is expressed by a bacteriophage, which phage is then used to detect the presence of the other member of the pair (termed the “ligand” or “target”). Rather than detecting the binding of the phage using antibody-based technology, the present invention relates to detecting the nucleic acid associated with the phage. In one aspect, the invention relates to identifying an antigen-bearing moiety (e.g., a red blood cell antigen) of interest present on a cell, e.g., a red blood cell, using antibody-displaying bacteriophage, as well as detecting anti-red blood cell auto- or alloantibodies and/or complement in a sample, using antiglobulin reagent-displaying bacteriophage and detecting a nucleic acid associated with the phage.
    Type: Application
    Filed: March 8, 2005
    Publication date: September 1, 2005
    Inventor: Donald Siegel
  • Publication number: 20050136399
    Abstract: The present invention relates to novel methods for detecting at least one member of a known binding pair in a sample, including a cell, where one member of the pair (termed the “receptor”) is expressed by a bacteriophage, which phage is then used to detect the presence of the other member of the pair (termed the “ligand” or “target”). Rather than detecting the binding of at least one phage using antibody-based technology, the present invention relates to detecting the nucleic acid associated with the phages. In one aspect, the invention relates to identifying at least one antigen-bearing moiety (e.g., a red blood cell antigen) of interest present on a cell, e.g., a red blood cell, using antibody-displaying bacteriophages, using antiglobulin reagent-displaying bacteriophages and detecting at least one nucleic acid associated with the phage.
    Type: Application
    Filed: October 22, 2004
    Publication date: June 23, 2005
    Inventor: Donald Siegel