Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.

Abstract: Provided herein are compounds of formula (I) and formula (II) that are inhibitors of QPCTL and QPCT: Also provided are pharmaceutical compositions comprising the compounds, and methods for using the compounds for the treatment of disease.

Abstract: Provided herein are inhibitors of PARG, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the PARG inhibitory compounds for the treatment of disease.

Abstract: A low-power platform senses an environment around the platform. The platform includes sensor interfaces, a multiplexer, a dual port memory, a processor, and a radio. The similar sensor interfaces are for attaching environmental sensors. The multiplexer combines the environmental data from the attached environmental sensors into a single stream. The dual port memory temporarily stores the stream. The processor intermittently retrieves the stream from the dual port memory. The radio forwards the stream toward a central system. Each interface includes a mechanical interlock for attaching a respective environmental sensor and an electrical interlock for detecting whether the mechanical interlock engages the environmental sensor. Each interface transfers peripheral power and environmental data for the respective environmental sensor.

Abstract: A low-power platform senses an environment around the platform. The platform includes sensor interfaces, a multiplexer, a dual port memory, a processor, and a radio. The similar sensor interfaces are for attaching environmental sensors. The multiplexer combines the environmental data from the attached environmental sensors into a single stream. The dual port memory temporarily stores the stream. The processor intermittently retrieves the stream from the dual port memory. The radio forwards the stream toward a central system. Each interface includes a mechanical interlock for attaching a respective environmental sensor and an electrical interlock for detecting whether the mechanical interlock engages the environmental sensor. Each interface transfers peripheral power and environmental data for the respective environmental sensor.

Abstract: A perpendicular magnetic recording (PMR) media including a non-magnetic or superparamagnetic grain isolation magnetic anisotropy layer (GIMAL) to provide a template for initially well-isolated small grain microstructure as well as improvement of Ku in core grains of a magnetic recording layer. The GIMAL composition may be adjusted to have lattice parameters similar to a bottom magnetic recording layer and to provide a buffer for reducing interface strains caused by lattice mismatch between the bottom magnetic recording layer and an underlying layer.

Abstract: Method of incorporating atomic oxygen into a magnetic recording layer by sputtering a target containing an oxide of cobalt. The oxide of cobalt may be sputtered to provide a readily dissociable source of oxygen which may increase the concentration of free cobalt atoms (Co) in the magnetic recording layer and also increase oxide content in the magnetic recording layer.

Abstract: A doctor blade (10) having a steel rod (11) attached to a stamped bracket (20) provides a radiused surface for contacting a developer roll (12). The doctor blade (10 ) includes a bracket member (20) having a mounting end (42), a doctoring end (44) and a bent portion (14) connecting the mounting end (42) to the doctoring end (44). The rod (11) is coupled to the bracket member (20) near the bent portion (14) and arranged to contact a developer roll (12) for precise toner metering.

Abstract: The present invention relates to packaging materials that may be used for components in an image forming apparatus. The packaging material may include polymeric fiber which may be in the form of a non-woven, woven or knit fabric. The fiber may contain less than 5.0% of compounds having molecular weights of equal to or less than about 2500. The packaging material may also absorb developing agent.

Abstract: An apparatus and method for the transport and/or storage of developing agent in an image forming apparatus. A cartridge may be employed having a reservoir for developing agent and a component, such as a drum, which may include an interior region capable of storing developing agent. A transport device may be included that is capable of transporting developing agent between the reservoir and a location in the image forming apparatus such as the drum interior.

Abstract: A magnetic recording medium constructed in accordance with the invention comprises a substrate, first, second and third underlayers formed over the substrate, and a magnetic data recording layer formed over the underlayers. The underlayers typically have a bcc crystal structure, and comprise Cr or Cr alloys. The magnetic data recording layer has a hcp crystal structure and comprises a Co alloy. The second underlayer typically comprises a material such as B, which tends to reduce the crystal size of the second underlayer and the layers deposited thereon, and also to increase crystal spacing.

Abstract: A conveyor mechanism for moving waste toner within an interior of a waste toner reservoir. The conveyor mechanism has a first end positioned in proximity to an inlet into the waste toner reservoir, and a second end positioned vertically above the first end. The conveyor mechanism operates to move the toner from a lower position within the waste toner reservoir to the vertically elevated position. The conveyor device may allow for the capacity of the waste toner reservoir to be more fully utilized. In use, the conveyor device is activated and waste toner is moved into the upper reaches of the waste toner reservoir.

Abstract: The present invention relates generally to image forming equipment, e.g. a laser printer of the type which includes a photoconductive (PC) drum and an associated charge roller. The invention is disclosed in exemplary embodiment as a laser printer incorporating a cleaner element with an electrical potential to sufficiently charge contamination particles on the PC drum to electrically repel from a charged surface, such as the charge roller.

Abstract: A magnetic recording medium includes a substrate, an underlayer, a lower magnetic layer formed on the underlayer, an intermediate layer, and an upper magnetic layer formed on the intermediate layer. The intermediate layer is typically Ru, and promotes anti ferromagnetic coupling between the upper and lower magnetic layers. The upper and lower magnetic layers are typically Co alloys. The lower magnetic layer has a high saturation magnetization Ms to promote high exchange coupling between the upper and lower magnetic layers. The dynamic coercivity of the lower magnetic layer is lower than the exchange field to ensure rapid switching of the lower magnetic layer.

Abstract: There is provided a system and mechanism for substantially reducing or substantially eliminating vibration or noise of a doctor blade of an image forming apparatus during operation. The system and mechanism provided includes at least one contact in communication with a doctor blade surface, e.g., a front surface, to substantially reduce or substantially eliminate vibration and/or noise associated with a doctor blade during image forming.

Abstract: The present invention relates to particle reinforced noble metal matrix composites and a method of making the same. The composites include a noble metal such as silver, gold, and alloys thereof, as a base or matrix, and a particle reinforced filler material, such as a carbide. A pressureless infrared heating, or superheating, process is used to produce the particle reinforced noble metal matrix composites thereby providing a composite with at least sufficient hardness, i.e. wear resistance, and/or low resistivity. The composites may be used in the jewelry industry, such as for making watches, rings, and other jewelry, and/or in the power, automobile, and aircraft industries, such as for making electrical contact materials.

Abstract: A doctor blade for use with an imaging apparatus includes an elongated member, and a metering surface formed on a portion of the elongated member. The metering surface has surface features, which are modified by buffing the metering surface.

Abstract: A magnetic recording medium constructed in accordance with the invention comprises a substrate, first, second and third underlayers formed over the substrate, and a magnetic data recording layer formed over the underlayers. The underlayers typically have a bcc crystal structure, and comprise Cr or Cr alloys. The magnetic data recording layer has a hcp crystal structure and comprises a Co alloy. The second underlayer typically comprises a material such as B, which tends to reduce the crystal size of the second underlayer and the layers deposited thereon, and also to increase crystal spacing.

Abstract: A magnetic recording medium includes a substrate, an underlayer, a lower magnetic layer formed on the underlayer, an intermediate layer, and an upper magnetic layer formed on the intermediate layer. The intermediate layer is typically Ru, and promotes anti ferromagnetic coupling between the upper and lower magnetic layers. The upper and lower magnetic layers are typically Co alloys. The lower magnetic layer has a high saturation magnetization Ms to promote high exchange coupling between the upper and lower magnetic layers. The dynamic coercivity of the lower magnetic layer is lower than the exchange field to ensure rapid switching of the lower magnetic layer.

Abstract: A magnetic recording medium includes a substrate, an underlayer, a lower magnetic layer formed on the underlayer, an intermediate layer, and an upper magnetic layer formed on the intermediate layer. The intermediate layer is typically Ru, and promotes antiferromagnetic coupling between the upper and lower magnetic layers. The upper and lower magnetic layers are typically Co alloys. The lower magnetic layer has a high saturation magnetization Ms to promote high exchange coupling between the upper and lower magnetic layers. The dynamic coercivity of the lower magnetic layer is lower than the exchange field to ensure rapid switching of the lower magnetic layer.