Abstract: An attitude indicator device for detecting, indicating, and/or logging the positional attitude of an individual in response to deviation from a set of one or more reference angles. By way of example and not of limitation, the device is mounted on the thigh of a patient and measurements are taken from an acceleration sensor within the device. The acceleration measurements are communicated to a receiver when the measurements deviate from acceptable thresholds, whereby the receiver indicates an alert condition. The device may be employed within numerous medical related applications, for example, to facilitate preventing patient egress and the prevention/detection of patient falls.

Abstract: An attitude indicator device for detecting, indicating, and/or logging the positional attitude of an individual in response to deviation from a set of one or more reference angles. By way of example and not of limitation, the device is mounted on the thigh of a patient and measurements are taken from an acceleration sensor within the device. The acceleration measurements are communicated to a receiver when the measurements deviate from acceptable thresholds, whereby the receiver indicates an alert condition. The device may be employed within numerous medical related applications, for example, to facilitate preventing patient egress and the prevention/detection of patient falls.

Abstract: An attitude indicator device for detecting, indicating, and/or logging the positional attitude of an individual in response to deviation from a set of one or more reference angles. By way of example and not of limitation, the device is mounted on the thigh of a patient and measurements are taken from an acceleration sensor within the device. The acceleration measurements are communicated to a receiver when the measurements deviate from acceptable thresholds, whereby the receiver indicates an alert condition. The device may be employed within numerous medical related applications, for example, to facilitate preventing patient egress and the prevention/detection of patient falls.

Abstract: An attitude indicator device for detecting, indicating, and/or logging the positional attitude of an individual in response to deviation from a set of one or more reference angles. By way of example and not of limitation, the device is mounted on the thigh of a patient and measurements are taken from an acceleration sensor within the device. The acceleration measurements are communicated to a receiver when the measurements deviate from acceptable thresholds, whereby the receiver indicates an alert condition. The device may be employed within numerous medical related applications, for example, to facilitate preventing patient egress and the prevention/detection of patient falls.

Abstract: An extracorporeal blood processing method and system wherein blood is extracted from a mammalian subject through a blood withdrawal tube having a blood pump, such as a peristaltic pump, positioned thereon. A "distal segment" of the blood withdrawal tube extends from the mammalian subject to the inlet side or withdrawal pump. A "proximal segment" of the blood withdrawal tube extends from the outlet side of the blood pump to an extracorporeal blood processing apparatus. An anticoagulant feed tube is connected to the "proximal segment" of the blood withdrawal tube such that a flow of anticoagulant solution may be combined with blood exiting the outlet of said blood pump and passing through the "proximal segment" of said blood withdrawal tubing.

Abstract: A dermal patch to be worn on the skin for increasing the concentration of an analyte expressed through the skin in perspiration to a conveniently measurable level. Included are patches and methods of using such patches to determine the quantity of an analyte in a given volume of perspiration, to determine a subject's sensitivity to an allergen, to allow an analyte to be detected with conventional detection systems, and to dissolve the structural components of a patch to facilitate analyte detection.

Abstract: A non-occlusive dermal patch for collecting vapor phase perspiration from a subject's skin and retaining an analyte such as ethanol in the perspiration is disclosed. A method of collecting vapor phase perspiration containing an analyte such as ethanol over a period up to several days and detecting the analyte to determine the wearer's consumption of the analyte during the period when the patch was worn is disclosed.

Abstract: A dermal patch to be worn on the skin for increasing the concentration of an analyte expressed through the skin in perspiration to a conveniently measurable level. Included are patches and methods of using such patches to determine the quantity of an analyte in a given volume of perspiration, to determine a subject's sensitivity to an allergen, to allow an analyte to be detected with conventional detection systems, and to dissolve the structural components of a patch to facilitate analyte detection.

Abstract: A membrane (250) comprising an adhesive is secured to the skin (12) of a subject. The membrane (250) retains concentrated analyte in or on the membrane (250) itself, in the adhesive, and in the desquamated keratinized stratum corneum cells of the skin (12).

Abstract: A process for filtration of matter from a liquid suspension through a membrane uses a rotor within a concentric shell rotating with a surface velocity which, together with the rotor-shell gap and suspension viscosity, establishes vigorous vortex cells about the rotor. At least one of the rotor and shell surfaces include a filter membrane. Tangential velocity components at the membrane surface constantly sweep the membrane surface to limit cell deposition tendencies while constantly replenishing the medium to be filtered. The vortex cells are established along the length of the membrane despite the constant extraction of filtrate and the resultant change in physical characteristics of the suspension.

Abstract: Disclosed is a method and apparatus for the non-invasive determination of one or more preselected analytes in a body fluid expressed through the skin. The fluid is collected in a dermal concentration patch and concentrated by driving off a portion of the substantial water fraction under the influence of body heat. The analyte is optimally complexed with an immobilized specific binding partner and an indicium of the presence of the analyte is visually expressed. The patch may comprise a plurality of test zones for screening for a plurality of analytes. Additional positive and negative control zones are also disclosed. The patch may comprise a feature to detect tampering with the patch to produce false negative results, especially when used in screens for drugs of abuse. In addition to being useful as a drug of abuse screen, the patch is useful for diagnostic purposes.

Abstract: Methods and devices for separating leukocytes from a leukocyte contaminated blood fraction by use of a rotating membrane filter apparatus. The invention includes methods/devices for preparing substantially leukocyte free platelet concentrate for therapeutic use. The devices of the invention include a rotating membrane filter apparatus for leukocyte separation as well as tubing harness/component systems (FIGS. 2a, 2b, 2c) useable in connection with automated apheresis instruments.

Abstract: A dermal patch to be worn on the skin for increasing the concentration of an analyte expressed through the skin in perspiration to a conveniently measurable level. Included are patches and methods of using such patches to determine the quantity of an analyte in a given volume of perspiration, to determine a subject's sensitivity to an allergen, to allow an analyte to be detected with conventional detection systems, and to dissolve the structural components of a patch to facilitate analyte detection.

Abstract: Methods and apparatus are disclosed for separating and collecting blood fractions or components such as platelets. A first anticoagulant solution is added to whole blood, which is then separated into platelet-rich plasma and red cells. A second anticoagulant is added to the platelet rich plasma, which is then separated into platelet-poor plasma and platelet concentrate. The rate of red cell sedimentation is increased and the time of the separation/collection procedure may be reduced when the pH of the first anticoagulant is greater than approximately 6.0.

Abstract: A dermal patch including a means for generating heat on the surface of the skin of a subject wearing the patch. The temperature of the surface of the skin under the patch is raised to about 115.degree. F., and perspiration is collected in the patch over the course of about an hour. The patch is then analyzed to determine the presence of an analyte in the patch.

Abstract: Disclosed is a method and apparatus for the non-invasive determination of one or more preselected analytes in a body fluid expressed through the skin. The fluid is collected in a dermal concentration patch and concentrated by driving off a portion of the substantial water fraction under the influence of body heat. The analyte is optimally complexed with an immobilized specific binding partner and an indicium of the presence of the analyte is visually expressed. The patch may comprise a plurality of test zones for screening for a plurality of analytes. Additional positive and negative control zones are also disclosed. The patch may comprise a feature to detect tampering with the patch to produce false negative results, especially when used in screens for drugs of abuse. In addition to being useful as a drug of abuse screen, the patch is useful for diagnostic purposes.

Abstract: A dermal patch to be worn on the skin for increasing the concentration of an analyte expressed through the skin in perspiration to a conveniently measurable level. Included are patches and methods of using such patches to determine the quantity of an analyte in a given volume of perspiration, to determine a subject's sensitivity to an allergen, to allow an analyte to be detected with conventional detection systems, and to dissolve the structural components of a patch to facilitate analyte detection.

Abstract: The invention is an improved method and apparatus for collecting analytes on a dermal patch, where the patch controls the ionization state of the analyte. This can be accomplished by delivering electricity to the patch or by a buffer or other means for controlling the pH of fluids entering the patch. Analytes in perspiration can be concentrated on the patch without the occurrence of significant back-diffusion of the analytes.

Abstract: Methods and devices for separating leukocytes from a leukocyte contaminated blood fraction by use of a rotating membrane filter apparatus. The invention includes methods/devices for preparing substantially leukocyte free platelet concentrate for therapeutic use. The devices of the invention include a rotating membrane filter apparatus for leukocyte separation as well as tubing harness/component systems (FIGS. 2a, 2b, 2c) useable in connection with automated apheresis instruments.

Abstract: Methods and apparatus for practical extracorporeal separation of fluorochemicals from clinically fluorochemical-containing whole blood of a patient. The methods incorporate centrifugal apheresis devices, preferably with low extracorporeal volumes, that provide a means for continuously removing separated fluorochemical-enriched fractions from the centrifuge during processing and return of whole blood-enriched fractions to the patient.