Abstract: The invention relates to modulators of Embryonic Ectoderm Development (EED) and/or Polycomb Repressive Complex 2 (PRC2) useful in the treatment of disorders and diseases associated with EEC and PRC2, being macrocyclic azolopyridine derivatives and compositions thereof of Formula I: or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, enantiomer, isomer, or tautomer thereof, wherein X1, X2, X3, A1, A2, Y, R1, R2, R3, and R4 are as described herein.

Abstract: Various aspects and embodiments are directed to a streamlined computer device and a graphical user interface that organizes interface elements into views of computer content for presentation to a user. Various views of digital media content permits users to easily and efficiently access various digital media content. Different views are used to provide an interface that is responsive to configurations of the device and responsive to activity being performed by the user. Aspects include permitting the user to maintain and manage digital media content libraries. According to some embodiments, the libraries comprise user digital media content and references digital media content. Functionality provided to a user can be tailored to the type of content displayed, accessed and/or managed. According to various aspects, methods and systems are provided for accessing and managing digital media libraries on a streamlined computing device with a plurality selectable I/O profiles.

Abstract: Methods, systems, and computer program products for synchronizing a subscriber profile in a plurality of domains is described. In one embodiment, the method includes receiving a profile update request message from an application server to modify an Internet protocol (IP) domain subscriber profile. The profile update request message is forwarded to a home location register (HLR). A cellular domain subscriber profile is modified in accordance with the profile update request message. Similarly, an updated subscriber profile data is received from the HLR. The updated subscriber profile data is converted in the IP domain. The converted updated subscriber profile data is sent to the application server.

Abstract: Methods, systems, and computer program products for synchronizing a subscriber profile in a plurality of domains is described. In one embodiment, the method includes receiving a profile update request message from an application server to modify an Internet protocol (IP) domain subscriber profile. The profile update request message is forwarded to a home location register (HLR). A cellular domain subscriber profile is modified in accordance with the profile update request message. Similarly, an updated subscriber profile data is received from the HLR. The updated subscriber profile data is converted in the IP domain. The converted updated subscriber profile data is sent to the application server.

Abstract: Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.

Abstract: A medical procedure fluid control apparatus includes a procedure bed, and at least one wing. The wing is along at least one longitudinal edge of the procedure bed, and is moveable to a plane non-parallel with a plane of the procedure bed. The apparatus has at least one absorbent portion being on a surface of the procedure bed or the wing. The at least one absorbent portion is disposed to face the patient. At least one adhesive portion of the fluid control apparatus is also on a surface of the procedure bed or said wing disposed to face patient.

Abstract: A medical splint and/or procedure fluid control apparatus includes a procedure bed, and at least one wing. The wing is along at least one longitudinal edge of the procedure bed, and is moveable to a plane non-parallel with a plane of the procedure bed. The apparatus has at least one absorbent portion being on a surface of the procedure bed or the wing. The at least one absorbent portion is disposed to face the patient. At least one adhesive portion of the fluid control apparatus is also on a surface of the procedure bed or said wing disposed to face patient. The splint and/or procedure apparatus may be made of molded pulp.

Abstract: Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked materials that may be used as adhesive compositions. The compositions comprise collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Methods for preparing and using the compositions are also provided. Exemplary uses include tissue augmentation, biologically active agent delivery, bioadhesion, prevention of adhesions following surgery or injury, and coating of surgically acceptable patches and solid implants, the latter including sutures.

Abstract: The invention provides recombinant procollagen chains having a natural collagen chain separated from one or two propeptide by one or two non-natural site-specific proteolytic agent (e.g., protease) recognition sites. A wide variety of propeptides and site-specific proteolytic agent recognition sites may be used: the selection of particular site-specific proteolytic agent/recognition site pairs is based on the conformation of the resulting procollagen, the availability of the site-specific proteolytic agent, the compatibility of the proteolysis with production of mature collagen, among other factors. Recombinant collagens chains are produced by contacting the subject recombinant procollagen chains with the appropriate site-specific proteolytic agents. Nucleic acids encoding the subject procollagen chains operably linked to transcription regulatory elements are used in vectors and cells for the production of recombinant collagen.

Abstract: A chain link fence tightening assembly for stretching a chain link fence adjacent to and beyond a first vertical post and toward a second vertical post such that the chain link fence may be attached to the first vertical post in a taut manner includes an elongated rod that is selectively coupled to a plurality of links of the chain link fence. A gripping member removably grips the second vertical post. A first cable and a second cable each have a first end and a second end. The first end of the first cable is attached to the rod and the first end of the second cable is attached to the gripping member. A winding assembly is attached to each of the first and second cables and is adapted for pulling the rod and the gripping member toward each other such that the chain link fence is pulled taut.

Abstract: A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Kits for use in carrying out the method of the invention are also provided, as are pretreated surgically acceptable patches that have been coated with the aforementioned adhesive composition.

Abstract: A well tester adapted to select among members of an oil well family to provide a purged and clean vessel to receive samples of well production that include gas and oil, and by selective use of production pressure and lease water under pressure, allow for the separation and separate measure of the oil and gas, and optionally to provide for improved sampling of production fluids with high gas/oil ratios.

Abstract: A well tester adapted to select among members of an oil well family to provide a purged and clean vessel to receive samples of well production that include gas and oil, and by selective use of production pressure and lease water under pressure, allow for the separation and separate measure of the oil and gas, and optionally to provide for improved sampling of production fluids with high gas/oil ratios.

Abstract: A centrifugal fan apparatus for installation in an air plenum adapted to provide pressurized air to a ventilating system includes a centrifugal fan rotor having front and rear sidewalls and a number of blades extending between these sidewalls. The platform has a horizontal base frame on which wheels are rotatably mounted. The front sidewall has a central opening for receiving air while the rear sidewall is attached to a rotatable drive shaft that extends rearwardly from the rotor. A motor is connected to the shaft in order to rotate it and the rotor. A linearly movable platform supports the rotor, shaft and motor and an actuator moves this platform forwardly or rearwardly in order to control the volume of air flowing out of the rotor. An air inlet member is mounted rigidly at the central opening and has a generally cylindrical section that can extend into the rotor when the rotor is moved to a forward position.

Abstract: Tissue adhesions are inhibited by applying and immobilizing a solid preformed matrix material over a target region, such as a surgical site, in a first tissue surface. The matrix material may be any continuous solid material, such as a sheet or film. After applying the material to the target region, the material is immobilized by applying energy over at least a portion of the surface of the matrix material which causes the material to fuse to the underlying tissue. The matrix material is preferably bioabsorbable so that it is resorbed by the body over time. Suitable matrix materials include proteins, polysaccharrides, and synthetic polymers.