Abstract: A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching a ?-nitrogen protect C?-carboxamide amino acid to a solid support by its side chain, removing the ?-nitrogen protecting group, assembling a peptide chain on said ?-nitrogen and then cleaving the assembled peptide amide from the solid support. Novel amino acid analogues, peptide amides and solid-phase supports are also provided.

Abstract: A polymer support is provided which comprises protected hydroxypolyC2-4alkyleneoxy chains attached to a cross-linked polymer wherein the protected hydroxypolyC2-4alkyleneoxy chain contains from 2 to 10 C2-4alkyleneoxy groups and wherein the hydroxypolyC2-4alkyleneoxy chains are protected with an acid labile group. The acid labile protecting group is preferably a poly-aryl methane protecting group. A monomer and process for the preparation of said support are also provided.