Abstract: An electroporation device adapted to perform the following operations: detect the resistance value RA,B between a pair of electrodes placed in a portion of human tissue; calculate, select and store a pair of values of total duration ?(n,t) and voltage V that satisfy the inequality: ? · [ ( V / d ) ] 2 · ? ? ( n , t ) ? > A ? D R where: ADR represents the energy dose that realises a reversible electroporation—the energy dose ADR is a known value stored in the device; ? is defined as the inverse of resistivity ?=1/; d is the spacing of the electrodes; the resistivity =R*S/d where R denotes the measured and stored resistance value and S the section of the electrodes; and control a power amplifier so that a voltage equal to the voltage V is applied to the electrodes and supplied to the tissue portion for the determined total duration ?.

Abstract: A high voltage pulse generator for electro-poration comprising: a capacitor bank in which the electric charge used to generate the pulses is stored; the capacitor bank has an output terminal on which a high voltage direct current HT is present; a voltage amplifier circuit which receives, at input, the high voltage direct current HT and is provided with an automatic gain control circuit designed to compare a reference voltage VHT-ref with the voltage supplied at output VOUT by the amplifier to maintain the voltage constant at output during generation of the pulses; a current amplifier circuit arranged downstream of the voltage amplifier circuit and provided with an electronic semiconductor switch communicating with a first terminal with the output of the capacitor bank and provided with a second terminal designed to communicate with an output of the pulse generator; the voltage present at the output of the voltage amplifier is supplied to the output of the pulse generator and is used to operate the switching d

Abstract: There is disclosed a method for the treatment of cerebral ischemic stroke in a subject in need thereof comprising the steps of (a) identifying an ischemic area of the brain of the subject; and (b) applying an effective electromagnetic field to the ischemic area of the brain, wherein the electromagnetic field is effective to reduce local edema, to increase neuronal survival and/or reduce neuronal apoptosis.

Abstract: A flexible electrode (1) for applying an electric field to the human body, comprising: a gripping portion (3); a deformable structure (5) having a first face (5a) fixed to the gripping portion (3); a flexible polymeric film (7) arranged on a flat second face (5b) of the deformable structure (5) and provided, on a flat face (7a) thereof facing outwards the electrode (1), with flat metal structures (10,11) defining at least one first electrode and one second electrode (A,B), surfaces (10a,11a) of the flat metal structures (10,11) facing outwards the polymeric film (7) being coplanar with the flat face (7a) of the polymeric film (7).

Abstract: A handling and control system for expandable electrodes of a handpiece is provided that includes a plurality of flexible electrodes made of elastic cables carried by a support assembly with needle-shaped front portions that protrude from the support assembly and move in a three-dimensional space under the push of actuators.

Abstract: A method for controlling an electroporation device configured for supplying an electrical power signal to a plurality of pairs of electrodes coupled to a portion of the human body, wherein the following steps are performed: detecting, in the course of an electroporation treatment, a condition of malfunctioning or fail for the pairs of electrodes for which at least one electrical parameter of the power signal supplied to the electrodes themselves has an anomalous value; storing an indicator of the pairs of electrodes in the fail condition; and selecting the pairs of electrodes in the fail condition and re-computing new parameters in order to implement a subsequent electroporation process.

Abstract: Hand held adjustable device comprising: a grip provided with an end portion; a plurality of needles which extend axially from the end portion and are made of electrically conductive material, and a device for adjusting the insertion depth of the needles in a tissue in which a cup-shaped body borne by said end portion of the grip is provided with an end wall having holes for the passage of said needles. A system for adjustment of the relative position between the cup-shaped body and the end portion provides an axial sliding of the cup-shaped body with respect to the end portion adjust the length of the portion of the needles protruding from said end wall and therefore the insertion depth in the tissue.

Abstract: There is disclosed a method for the treatment of cerebral ischemic stroke in a subject in need thereof comprising the steps of (a) identifying an ischemic area of the brain of the subject; and (b) applying an effective electromagnetic field to the ischemic area of the brain, wherein the electromagnetic field is effective to reduce local edema, to increase neuronal survival and/or reduce neuronal apoptosis.

Abstract: A method for controlling an electroporation device configured for supplying an electrical power signal to a plurality of pairs of electrodes coupled to a portion of the human body, wherein the following steps are performed: detecting, in the course of an electroporation treatment, a condition of malfunctioning or fail for the pairs of electrodes for which at least one electrical parameter of the power signal supplied to the electrodes themselves has an anomalous value; storing an indicator of the pairs of electrodes in the fail condition; and selecting the pairs of electrodes in the fail condition and re-computing new parameters in order to implement a subsequent electroporation process.

Abstract: Hand held adjustable device comprising: a grip provided with an end portion; a plurality of needles which extend axially from the end portion and are made of electrically conductive material, and a device for adjusting the insertion depth of the needles in a tissue in which a cup-shaped body borne by said end portion of the grip is provided with an end wall having holes for the passage of said needles. A system for adjustment of the relative position between the cup-shaped body and the end portion provides an axial sliding of the cup-shaped body with respect to the end portion adjust the length of the portion of the needles protruding from said end wall and therefore the insertion depth in the tissue.

Abstract: A medical device, in particular for electroporation treatment, characterized by having: a thimble-like main body fitted, in use, to a hand of an operator; and a member connected to the main body and fitted with needles by which the operator performs the therapeutic treatment.

Abstract: A reversible electroporation device in which an electric pulse generator generates a sequence of electric pulses delivered to electrodes coupled to a tissue in which a process of reversible electroporation that generates cell apoptosis is to be performed. The device is configured to control the amplitude of the pulses and the number of the pulses delivered to the electrodes so that the amount of energy per weight unit (absorbed dose) applied to the tissue is in a range between a first lower limit value of about 3000 J/kg and a second upper limit value of about 4500 J/kg.

Abstract: A medical device, in particular for electroporation treatment, characterized by having: a thimble-like main body fitted, in use, to a hand of an operator; and a member connected to the main body and fitted with needles by which the operator performs the therapeutic treatment.

Abstract: Device for the regeneration and prevention of degeneration of the cartilage and subchondral bone, the proliferation of chondrocytes and for blocking or reducing the fibroblastic evolution of chondrocytes and mesenchymal cells by means of electromagnetic waves comprising a device for generating a periodic signal u(t) and a power amplifier suitable for applying the signal u(t) to a pair of solenoids for the generation of an electromagnetic field M(t) addressed towards a portion of human/animal body containing cartilage. Setting means are provided for the generation of an electromagnetic field having intensity between 0.5 and 2 milliTesla, frequency between 37 and 75 Hz and period of application between 1 hour and 9 hours.

Abstract: A portable generator generates a predetermined signal and has an output connected to a first transducer for transmitting the above signal to the body of a first operator (e.g. physician, nurse, etc.); and processing means for analyzing a signal picked up by a second transducer on a second operator (e.g. a patient, etc.) and detecting the significant presence of the above predetermined signal, as a consequence, for example, of direct or indirect contact between the first operator and the second operator.

Abstract: A portable generator generates a predetermined signal and has an output connected to a first transducer for transmitting the above signal to the body of a first operator (e.g. physician, nurse, etc.); and processing means for analyzing a signal picked up by a second transducer on a second operator (e.g. a patient, etc.) and detecting the significant presence of the above predetermined signal, as a consequence, for example, of direct or indirect contact between the first operator and the second operator.

Abstract: A method for treating living tissues and/or cells consisting essentially of electromagnetically inducing in the tissues and/or cells alternating pulsating electrical signals having a wave form which comprises a positive portion with a duration of between 1 and 3 milliseconds, and a negative portion having a peak value less than that of the positive portion, followed by a region of exponential extension tending to the reference value zero.

Abstract: A method for treating living tissues and/or cells consisting essentially of electromagnetically inducing in the tissue and/or cells alternating pulsating electrical signals having a wave form which comprises a positive portion with a duration of between 1 and 3 milliseconds, and a negative portion having a peak value less than that of the positive portion, followed by a region of exponential extension tending to the reference value zero.