Patents by Inventor Donata R. Sizemore

Donata R. Sizemore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bacterial delivery system
    Patent number: 7235234
    Abstract: We describe a bacterial delivery system for the delivery of DNA and antigens into cells. We constructed an attenuated bacterial vector which enters mammalian cells and ruptures delivering functional plasmid DNA and antigens into the cell cytoplasm. This Shigella vector was designed to deliver DNA to colonic surfaces, thus opening the possibility of oral and other mucosal DNA immunization and gene therapy strategies. The attenuated Shigella is also useful as a vaccine for reducing disease symptoms caused by Shigella.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: June 26, 2007
    Assignee: United States of America as Represented by the Secretary of the Army
    Inventors: Arthur A. Branstrom, Donata R. Sizemore, Jerald C. Sadoff
  • Bacterial delivery system
    Patent number: 7045336
    Abstract: We describe a bacterial delivery system for the delivery of DNA and antigens into cells. We constructed an attenuated bacterial vector which enters mammalian cells and ruptures delivering functional plasmid DNA and antigens into the cell cytoplasm. This Shigella vector was designed to deliver DNA to colonic surfaces, thus opening the possibility of oral and other mucosal DNA immunization and gene therapy strategies. The attenuated Shigella is also useful as a vaccine for reducing disease symptoms caused by Shigella.
    Type: Grant
    Filed: September 6, 1996
    Date of Patent: May 16, 2006
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Arthur A. Branstrom, Donata R. Sizemore, Jerald C. Sadoff
  • Antimicrobial mediated bacterial DNA delivery
    Publication number: 20020176848
    Abstract: This invention pertains in part to a method for delivering functional DNA or antigens. The desired DNA is introduced into attenuated bacteria able to enter cells. Once the bacteria is in the cell, antimicrobial agents are introduced such that they enter the mammalian cell and lyse the bacteria thereby allowing the delivery of carried functional DNA or antigens. The advantages of this method and its uses are described.
    Type: Application
    Filed: May 16, 2002
    Publication date: November 28, 2002
    Inventors: Donata R. Sizemore, Jerald C. Sadoff, Jason C. Grove
  • Antimicrobial mediated bacterial DNA delivery
    Patent number: 6410012
    Abstract: This invention pertains in part to a method for delivering functional DNA or antigens. The desired DNA is introduced into attenuated bacteria able to enter cells. Once the bacteria is in the cell, antimicrobial agents are introduced such that they enter the mammalian cell and lyse the bacteria thereby allowing the delivery of carried functional DNA or antigens. The advantages of this method and its uses are described.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: June 25, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Donata R. Sizemore, Jerald C. Sadoff, Jason C. Grove
  • Shigella vector for delivering DNA to a mammalian cell
    Patent number: 5824538
    Abstract: We describe a bacterial delivery system for the delivery of DNA and antigens into cells. We constructed an attenuated bacterial vector which enters mammalian cells and ruptures delivering functional plasmid DNA, such as a mammalian expression plasmid, and antigens into the cell cytoplasm. This Shigella vector was designed to deliver DNA to colonic surfaces, thus opening the possibility of oral and other mucosal DNA immunization and gene therapy strategies. The attenuated Shigella is also useful as a vaccine for reducing disease symptoms caused by Shigella.
    Type: Grant
    Filed: September 6, 1995
    Date of Patent: October 20, 1998
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Arthur A. Branstrom, Donata R. Sizemore, Jerald C. Sadoff