Patents by Inventor Donatella Aldinucci

Donatella Aldinucci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gold (III) complexes with oligopeptides functionalized with sulfur donors and use thereof as antitumor agents
    Patent number: 8481496
    Abstract: The invention concerns Au(III) complexes of the type [AuIIIX2(Pdtc)] (X=halogen, pseudo-halogen; pdtc=peptide-/esterified peptidedithiocarbamato) which are able to both maintain the antitumor properties and the lack of nephrotoxic side-effects of the previously reported Au(III)-dithiocarbamato complexes, together with an improved bioavailability through the peptide-mediated cellular internalization. The Au(III) complexes described have shown a significant biological activity on human tumor cell lines and, thus, they can be advantageously used as antineoplastic agents. The preparation method and use for the treatment of tumor pathologies of the Au(III) complexes of the invention are further described.
    Type: Grant
    Filed: March 20, 2009
    Date of Patent: July 9, 2013
    Assignees: Universita' Degli Studi di Padova, Centro di Riferimento Oncologico, Wayne State University Board of Govenors
    Inventors: Dolores Fregona, Luca Ronconi, Fernando Formaggio, Q. Ping Dou, Donatella Aldinucci
  • GOLD (III) COMPLEXES WITH OLIGOPEPTIDES FUNCTIONALIZED WITH SULFUR DONORS AND USE THEREOF AS ANTITUMOR AGENTS
    Publication number: 20120101044
    Abstract: The invention concerns Au(III) complexes of the type [AuIIIX2(Pdtc)] (X=halogen, pseudo-halogen; pdtc=peptide-/esterified peptidedithiocarbamato) which are able to both maintain the antitumor properties and the lack of nephrotoxic side-effects of the previously reported Au(III)-dithiocarbamato complexes, together with an improved bioavailability through the peptide-mediated cellular internalization. The Au(III) complexes described have shown a significant biological activity on human tumor cell lines and, thus, they can be advantageously used as antineoplastic agents. The preparation method and use for the treatment of tumor pathologies of the Au(III) complexes of the invention are further described.
    Type: Application
    Filed: March 20, 2009
    Publication date: April 26, 2012
    Inventors: Dolores Fregona, Luca Ronconi, Fernando Formaggio, Q. Ping Dou, Donatella Aldinucci